Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              18    1135
XP_005248577                                                           18    1135
XP_005248576                                                           18    1135
NP_005036                                                              17    2528
NP_774959                                                              17    2528
NP_001264671                                                           17    2528
NP_063938                                                              17    2528
XP_005264490                                                           17    2528
NP_005948                                                              16    5631
NP_001107644                                                           16    5631
NP_003620                                                              16    5631
XP_005271347                                                           16    5631
XP_005263520                                                           16    5631
XP_005263519                                                           16    5631
XP_005263518                                                           16    5631
XP_005263517                                                           16    5631
XP_005263515                                                           16    5631
NP_001121619                                                           16    7355
NP_001171809                                                           16    7355
NP_001098713                                                           16    7355
NP_065817                                                              16    7355
NP_000258                                                              16    7355
NP_001035957                                                           16    7355
XP_006721991                                                           16    7355
XP_006721990                                                           16    7355
XP_006721989                                                           16    7355
XP_005258041                                                           16    7355
XP_006721988                                                           16    7355
XP_006721987                                                           16    7355
XP_006721986                                                           16    7355
XP_005258040                                                           16    7355
XP_006721985                                                           16    7355
NP_056510                                                              15    9605
XP_006715123                                                           15    9605
XP_005249068                                                           15    9605
XP_005249067                                                           15    9605
NP_839943                                                              15    9605
>NP_005912
          Length = 1512

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLVVEDTLD 9
           QL VEDTLD
Sbjct: 870 QLGVEDTLD 878
>XP_005248577
          Length = 1349

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLVVEDTLD 9
           QL VEDTLD
Sbjct: 707 QLGVEDTLD 715
>XP_005248576
          Length = 1375

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLVVEDTLD 9
           QL VEDTLD
Sbjct: 733 QLGVEDTLD 741
>NP_005036
          Length = 3460

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QLVVEDTLD 9
           Q+V+ED+LD
Sbjct: 357 QVVLEDSLD 365
>NP_774959
          Length = 3458

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QLVVEDTLD 9
           Q+V+ED+LD
Sbjct: 357 QVVLEDSLD 365
>NP_001264671
          Length = 437

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLVVEDTL 8
          QLV++DTL
Sbjct: 87 QLVIQDTL 94
>NP_063938
          Length = 512

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QLVVEDTL 8
           QLV++DTL
Sbjct: 162 QLVIQDTL 169
>XP_005264490
          Length = 454

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QLVVEDTL 8
           QLV++DTL
Sbjct: 104 QLVIQDTL 111
>NP_005948
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VVEDTLD 9
           VVEDTL+
Sbjct: 635 VVEDTLE 641
>NP_001107644
          Length = 461

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QLVVEDTLD 9
           QLV ED +D
Sbjct: 167 QLVKEDNID 175
>NP_003620
          Length = 461

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QLVVEDTLD 9
           QLV ED +D
Sbjct: 167 QLVKEDNID 175
>XP_005271347
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QLVVEDTLD 9
           QLV ED +D
Sbjct: 184 QLVKEDNID 192
>XP_005263520
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VVEDTLD 9
           VVEDTL+
Sbjct: 553 VVEDTLE 559
>XP_005263519
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VVEDTLD 9
           VVEDTL+
Sbjct: 635 VVEDTLE 641
>XP_005263518
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VVEDTLD 9
           VVEDTL+
Sbjct: 635 VVEDTLE 641
>XP_005263517
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VVEDTLD 9
           VVEDTL+
Sbjct: 635 VVEDTLE 641
>XP_005263515
          Length = 697

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VVEDTLD 9
           VVEDTL+
Sbjct: 676 VVEDTLE 682
>NP_001121619
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>NP_001171809
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLVVEDTLD 9
           +LVVE +LD
Sbjct: 189 ELVVEKSLD 197
>NP_001098713
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLVVEDTLD 9
           +LVVE +LD
Sbjct: 189 ELVVEKSLD 197
>NP_065817
          Length = 1100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLVVEDTLD 9
           +LVVE +LD
Sbjct: 189 ELVVEKSLD 197
>NP_000258
          Length = 2818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>NP_001035957
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>XP_006721991
          Length = 1632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>XP_006721990
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>XP_006721989
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>XP_005258041
          Length = 2836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>XP_006721988
          Length = 2846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>XP_006721987
          Length = 2849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>XP_006721986
          Length = 2854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 70 QLIILDTLE 78
>XP_005258040
          Length = 2857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>XP_006721985
          Length = 2867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLVVEDTLD 9
          QL++ DTL+
Sbjct: 83 QLIILDTLE 91
>NP_056510
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LVVEDTLD 9
            L VEDT+D
Sbjct: 1156 LGVEDTVD 1163
>XP_006715123
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVVEDTLD 9
           L VEDT+D
Sbjct: 523 LGVEDTVD 530
>XP_005249068
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LVVEDTLD 9
            L VEDT+D
Sbjct: 1156 LGVEDTVD 1163
>XP_005249067
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LVVEDTLD 9
            L VEDT+D
Sbjct: 1156 LGVEDTVD 1163
>NP_839943
          Length = 1631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VVEDTL 8
           VVEDTL
Sbjct: 222 VVEDTL 227
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.136    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 478,968
Number of extensions: 530
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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