Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              19     665
NP_660153                                                              16    5631
NP_001159749                                                           16    5631
NP_001007232                                                           16    5631
NP_055697                                                              16    5631
NP_001159748                                                           16    5631
XP_006717674                                                           16    5631
XP_006717673                                                           16    5631
XP_006717672                                                           16    5631
XP_005269546                                                           16    5631
XP_005269545                                                           16    5631
XP_006717671                                                           16    5631
XP_006717670                                                           16    5631
XP_006717669                                                           16    5631
XP_006717668                                                           16    5631
XP_006717667                                                           16    5631
XP_005264733                                                           16    5631
XP_005264732                                                           16    5631
NP_000368                                                              16    7355
NP_055950                                                              16    7355
NP_001275682                                                           16    7355
NP_005487                                                              16    7355
NP_001002800                                                           16    7355
XP_005266998                                                           16    7355
NP_116191                                                              15    9605
NP_001277622                                                           15    9605
NP_079174                                                              15    9605
NP_001277260                                                           15    9605
NP_055524                                                              15    9605
NP_004652                                                              15    9605
NP_060890                                                              15    9605
XP_006722969                                                           15    9605
XP_006722968                                                           15    9605
XP_005259703                                                           15    9605
XP_005254781                                                           15    9605
XP_005254780                                                           15    9605
XP_005254779                                                           15    9605
XP_006710817                                                           15    9605
XP_005271062                                                           15    9605
XP_005271061                                                           15    9605
XP_006710816                                                           15    9605
>NP_004110
          Length = 993

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           QL DAEEAM
Sbjct: 946 QLADAEEAM 954
>NP_660153
          Length = 1121

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QLTDAEEAM 9
            +LT+AE+A+
Sbjct: 1048 ELTEAEDAL 1056
>NP_001159749
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QLTDAEEA 8
           QLT+A+EA
Sbjct: 221 QLTNADEA 228
>NP_001007232
          Length = 646

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QLTDAEEA 8
           QLT+A+EA
Sbjct: 261 QLTNADEA 268
>NP_055697
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QLTDAEEA 8
           QLT+A+EA
Sbjct: 253 QLTNADEA 260
>NP_001159748
          Length = 639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QLTDAEEA 8
           QLT+A+EA
Sbjct: 254 QLTNADEA 261
>XP_006717674
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QLTDAEEAM 9
           +LT+AE+A+
Sbjct: 856 ELTEAEDAL 864
>XP_006717673
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QLTDAEEAM 9
           +LT+AE+A+
Sbjct: 856 ELTEAEDAL 864
>XP_006717672
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QLTDAEEAM 9
           +LT+AE+A+
Sbjct: 856 ELTEAEDAL 864
>XP_005269546
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QLTDAEEAM 9
           +LT+AE+A+
Sbjct: 856 ELTEAEDAL 864
>XP_005269545
          Length = 1051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QLTDAEEAM 9
           +LT+AE+A+
Sbjct: 978 ELTEAEDAL 986
>XP_006717671
          Length = 1091

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QLTDAEEAM 9
            +LT+AE+A+
Sbjct: 1018 ELTEAEDAL 1026
>XP_006717670
          Length = 1120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QLTDAEEAM 9
            +LT+AE+A+
Sbjct: 1047 ELTEAEDAL 1055
>XP_006717669
          Length = 1120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QLTDAEEAM 9
            +LT+AE+A+
Sbjct: 1047 ELTEAEDAL 1055
>XP_006717668
          Length = 1121

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QLTDAEEAM 9
            +LT+AE+A+
Sbjct: 1048 ELTEAEDAL 1056
>XP_006717667
          Length = 1121

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QLTDAEEAM 9
            +LT+AE+A+
Sbjct: 1048 ELTEAEDAL 1056
>XP_005264733
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QLTDAEEA 8
           QLT+A+EA
Sbjct: 222 QLTNADEA 229
>XP_005264732
          Length = 645

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QLTDAEEA 8
           QLT+A+EA
Sbjct: 260 QLTNADEA 267
>NP_000368
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QLTDAE 6
           QLTDAE
Sbjct: 280 QLTDAE 285
>NP_055950
          Length = 2012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           + T+A+EAM
Sbjct: 351 EFTEADEAM 359
>NP_001275682
          Length = 1263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           QLT A+EA+
Sbjct: 494 QLTKAKEAL 502
>NP_005487
          Length = 1288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           QLT A+EA+
Sbjct: 519 QLTKAKEAL 527
>NP_001002800
          Length = 1288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           QLT A+EA+
Sbjct: 519 QLTKAKEAL 527
>XP_005266998
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TDAEEA 8
           TDAEEA
Sbjct: 610 TDAEEA 615
>NP_116191
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QLTDAEEAM 9
          QLT A+EA+
Sbjct: 21 QLTAAQEAI 29
>NP_001277622
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  QLTDAEE 7
          ++TDAEE
Sbjct: 51 EVTDAEE 57
>NP_079174
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           Q+T+AEE +
Sbjct: 122 QVTEAEELL 130
>NP_001277260
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLTDAEEAM 9
          Q+T+AEE +
Sbjct: 78 QVTEAEELL 86
>NP_055524
          Length = 3546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           +L+D EE+M
Sbjct: 553 RLSDTEESM 561
>NP_004652
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QLTDAEEA 8
           QLT++E+A
Sbjct: 479 QLTESEQA 486
>NP_060890
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QLTDAEEAM 9
           +L++AEEA+
Sbjct: 257 RLSEAEEAL 265
>XP_006722969
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QLTDAEEAM 9
          Q+T+AEE +
Sbjct: 78 QVTEAEELL 86
>XP_006722968
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           Q+T+AEE +
Sbjct: 259 QVTEAEELL 267
>XP_005259703
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLTDAEEAM 9
           Q+T+AEE +
Sbjct: 259 QVTEAEELL 267
>XP_005254781
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QLTDAEEAM 9
          QLT A+EA+
Sbjct: 21 QLTAAQEAI 29
>XP_005254780
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QLTDAEEAM 9
          QLT A+EA+
Sbjct: 21 QLTAAQEAI 29
>XP_005254779
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QLTDAEEAM 9
          QLT A+EA+
Sbjct: 21 QLTAAQEAI 29
>XP_006710817
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  QLTDAEEAM 9
          +L++AEEA+
Sbjct: 25 RLSEAEEAL 33
>XP_005271062
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  QLTDAEEAM 9
          +L++AEEA+
Sbjct: 26 RLSEAEEAL 34
>XP_005271061
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QLTDAEEAM 9
           +L++AEEA+
Sbjct: 257 RLSEAEEAL 265
>XP_006710816
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QLTDAEEAM 9
           +L++AEEA+
Sbjct: 186 RLSEAEEAL 194
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.110    0.257 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 509,902
Number of extensions: 897
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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