Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              18    1482
XP_005250103                                                           18    1482
XP_005250102                                                           18    1482
NP_203751                                                              17    3301
XP_006714457                                                           17    3301
XP_006714456                                                           17    3301
XP_005263376                                                           17    3301
NP_000866                                                              16    5631
NP_212133                                                              16    5631
NP_940938                                                              16    5631
NP_001138888                                                           16    5631
XP_005259958                                                           16    5631
XP_005259957                                                           16    5631
XP_005259959                                                           16    5631
XP_005259956                                                           16    5631
XP_005259955                                                           16    5631
XP_005254953                                                           16    5631
XP_006720550                                                           16    5631
XP_006720549                                                           16    5631
NP_689585                                                              16    7355
NP_579872                                                              16    7355
NP_001139669                                                           16    7355
NP_954981                                                              16    7355
NP_036492                                                              16    7355
NP_005912                                                              15    9605
NP_055523                                                              15    9605
NP_009121                                                              15    9605
NP_001258966                                                           15    9605
NP_001137359                                                           15    9605
NP_001128248                                                           15    9605
NP_001128247                                                           15    9605
NP_663782                                                              15    9605
NP_004227                                                              15    9605
NP_071940                                                              15    9605
NP_065907                                                              15    9605
NP_001118                                                              15    9605
NP_659428                                                              15    9605
NP_065810                                                              15    9605
NP_055646                                                              15    9605
XP_005261214                                                           15    9605
XP_006720684                                                           15    9605
XP_005268066                                                           15    9605
XP_006719769                                                           15    9605
XP_006718728                                                           15    9605
XP_005274241                                                           15    9605
XP_005274240                                                           15    9605
XP_005274239                                                           15    9605
XP_005269527                                                           15    9605
XP_005269526                                                           15    9605
XP_005248577                                                           15    9605
XP_005248576                                                           15    9605
XP_006713495                                                           15    9605
NP_001159491                                                           15    9605
NP_073733                                                              15    9605
>NP_004324
          Length = 766

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLHLLFVSK 9
           QL LLFVSK
Sbjct: 285 QLDLLFVSK 293
>XP_005250103
          Length = 758

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLHLLFVSK 9
           QL LLFVSK
Sbjct: 285 QLDLLFVSK 293
>XP_005250102
          Length = 767

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLHLLFVSK 9
           QL LLFVSK
Sbjct: 285 QLDLLFVSK 293
>NP_203751
          Length = 1143

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QLHLLFV 7
           +LHLLFV
Sbjct: 376 ELHLLFV 382
>XP_006714457
          Length = 809

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  QLHLLFV 7
          +LHLLFV
Sbjct: 42 ELHLLFV 48
>XP_006714456
          Length = 1143

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QLHLLFV 7
           +LHLLFV
Sbjct: 376 ELHLLFV 382
>XP_005263376
          Length = 1143

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QLHLLFV 7
           +LHLLFV
Sbjct: 376 ELHLLFV 382
>NP_000866
          Length = 1367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHLLFVSK 9
          LH+L +SK
Sbjct: 59 LHILLISK 66
>NP_212133
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLHLLFVS 8
          QL+LLF+S
Sbjct: 88 QLYLLFLS 95
>NP_940938
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLHLLFVS 8
          QL+LLF+S
Sbjct: 88 QLYLLFLS 95
>NP_001138888
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLHLLFVS 8
          QL+LLF+S
Sbjct: 88 QLYLLFLS 95
>XP_005259958
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLHLLFVS 8
          QL+LLF+S
Sbjct: 88 QLYLLFLS 95
>XP_005259957
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLHLLFVS 8
          QL+LLF+S
Sbjct: 88 QLYLLFLS 95
>XP_005259959
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLHLLFVS 8
          QL+LLF+S
Sbjct: 88 QLYLLFLS 95
>XP_005259956
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLHLLFVS 8
          QL+LLF+S
Sbjct: 88 QLYLLFLS 95
>XP_005259955
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  QLHLLFVS 8
          QL+LLF+S
Sbjct: 88 QLYLLFLS 95
>XP_005254953
          Length = 1366

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHLLFVSK 9
          LH+L +SK
Sbjct: 59 LHILLISK 66
>XP_006720550
          Length = 1373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHLLFVSK 9
          LH+L +SK
Sbjct: 66 LHILLISK 73
>XP_006720549
          Length = 1374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHLLFVSK 9
          LH+L +SK
Sbjct: 66 LHILLISK 73
>NP_689585
          Length = 1437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QLHLLFVSK 9
            +LHL+F +K
Sbjct: 1036 ELHLIFNNK 1044
>NP_579872
          Length = 59

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHLLFVSK 9
          LHLLF+ +
Sbjct: 29 LHLLFLKR 36
>NP_001139669
          Length = 7081

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LHLLFVSK 9
           LHL+ VSK
Sbjct: 541 LHLISVSK 548
>NP_954981
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLLFVSK 9
           H+LF+SK
Sbjct: 135 HVLFLSK 141
>NP_036492
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  QLHLLFV 7
          Q HLLFV
Sbjct: 23 QQHLLFV 29
>NP_005912
          Length = 1512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHLLFV 7
           +HLLFV
Sbjct: 356 IHLLFV 361
>NP_055523
          Length = 2209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QLHLLF 6
          QLHL+F
Sbjct: 78 QLHLVF 83
>NP_009121
          Length = 1000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LHLLFVSK 9
           LH LF+S+
Sbjct: 562 LHALFMSR 569
>NP_001258966
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  QLHLLFV 7
          QLH LF+
Sbjct: 59 QLHFLFL 65
>NP_001137359
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   QLHLLFVSK 9
           ++H+ F+SK
Sbjct: 375 RIHIPFISK 383
>NP_001128248
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLLFVSK 9
           HLLF+S+
Sbjct: 136 HLLFMSQ 142
>NP_001128247
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLLFVSK 9
           HLLF+S+
Sbjct: 136 HLLFMSQ 142
>NP_663782
          Length = 939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHLLFV 7
           LH+LFV
Sbjct: 824 LHILFV 829
>NP_004227
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   QLHLLFVSK 9
           ++H+ F+SK
Sbjct: 368 RIHIPFISK 376
>NP_071940
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LHLLFV 7
          LH+LFV
Sbjct: 11 LHILFV 16
>NP_065907
          Length = 1081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    HLLFVSK 9
            HLL+VS+
Sbjct: 1071 HLLYVSE 1077
>NP_001118
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHLLFV 7
           LH+LFV
Sbjct: 831 LHILFV 836
>NP_659428
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   QLHLLFV 7
           QLH LF+
Sbjct: 127 QLHFLFL 133
>NP_065810
          Length = 4700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QLHLLFVS 8
           QLH +F+S
Sbjct: 843 QLHSIFLS 850
>NP_055646
          Length = 2925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LHLLFVSK 9
            LH +FV+K
Sbjct: 1146 LHQIFVTK 1153
>XP_005261214
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  QLHLLFV 7
          QLH LF+
Sbjct: 59 QLHFLFL 65
>XP_006720684
          Length = 4713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QLHLLFVS 8
           QLH +F+S
Sbjct: 856 QLHSIFLS 863
>XP_005268066
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHLLFV 7
           LH+LFV
Sbjct: 245 LHILFV 250
>XP_006719769
          Length = 2209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QLHLLF 6
          QLHL+F
Sbjct: 78 QLHLVF 83
>XP_006718728
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLLFVSK 9
           HLLF+S+
Sbjct: 136 HLLFMSQ 142
>XP_005274241
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLLFVSK 9
           HLLF+S+
Sbjct: 136 HLLFMSQ 142
>XP_005274240
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLLFVSK 9
           HLLF+S+
Sbjct: 136 HLLFMSQ 142
>XP_005274239
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLLFVSK 9
           HLLF+S+
Sbjct: 136 HLLFMSQ 142
>XP_005269527
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LHLLFVSK 9
           LH LF+S+
Sbjct: 515 LHALFMSR 522
>XP_005269526
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LHLLFVSK 9
           LH LF+S+
Sbjct: 562 LHALFMSR 569
>XP_005248577
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHLLFV 7
           +HLLFV
Sbjct: 193 IHLLFV 198
>XP_005248576
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHLLFV 7
           +HLLFV
Sbjct: 219 IHLLFV 224
>XP_006713495
          Length = 2969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LHLLFVSK 9
            LH +FV+K
Sbjct: 1190 LHQIFVTK 1197
>NP_001159491
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHLLFV 7
           LH+LFV
Sbjct: 804 LHILFV 809
>NP_073733
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLLFVSK 9
           HLLF+S+
Sbjct: 136 HLLFMSQ 142
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.146    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 557,931
Number of extensions: 907
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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