Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              22      79
XP_005250103                                                           22      79
XP_005250102                                                           22      79
NP_002871                                                              20     299
XP_005265417                                                           20     299
XP_005265416                                                           20     299
XP_005265415                                                           20     299
XP_005265414                                                           20     299
XP_005265412                                                           20     299
NP_001007467                                                           18    1135
NP_064630                                                              18    1135
NP_001243125                                                           18    1135
NP_001645                                                              18    1135
XP_006724592                                                           18    1135
XP_005267114                                                           18    1135
NP_001011718                                                           17    3301
NP_001252                                                              17    4312
XP_006726390                                                           17    4312
XP_006726389                                                           17    4312
XP_006726388                                                           17    4312
XP_006726387                                                           17    4312
XP_006711142                                                           17    4312
XP_006711141                                                           17    4312
XP_006711140                                                           17    4312
XP_006710131                                                           17    4312
XP_006710130                                                           17    4312
XP_006710129                                                           17    4312
XP_006710128                                                           17    4312
NP_689703                                                              16    7355
NP_001264084                                                           16    7355
NP_775871                                                              16    7355
XP_005259087                                                           16    7355
XP_006723320                                                           16    7355
XP_005259086                                                           16    7355
XP_006723319                                                           16    7355
XP_005259085                                                           16    7355
XP_006711813                                                           16    7355
XP_005273128                                                           16    7355
XP_006711812                                                           16    7355
NP_060498                                                              16    7355
NP_001277482                                                           15    9605
NP_001277486                                                           15    9605
NP_001277558                                                           15    9605
NP_057083                                                              15    9605
NP_660288                                                              15    9605
NP_077283                                                              15    9605
NP_001153416                                                           15    9605
XP_005272515                                                           15    9605
XP_005253387                                                           15    9605
XP_006719103                                                           15    9605
XP_005253383                                                           15    9605
>NP_004324
          Length = 766

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLAIVAQWC 9
           QLAIV QWC
Sbjct: 524 QLAIVTQWC 532
>XP_005250103
          Length = 758

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLAIVAQWC 9
           QLAIV QWC
Sbjct: 524 QLAIVTQWC 532
>XP_005250102
          Length = 767

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLAIVAQWC 9
           QLAIV QWC
Sbjct: 524 QLAIVTQWC 532
>NP_002871
          Length = 648

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LAIVAQWC 9
           LAIV QWC
Sbjct: 417 LAIVTQWC 424
>XP_005265417
          Length = 494

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LAIVAQWC 9
           LAIV QWC
Sbjct: 417 LAIVTQWC 424
>XP_005265416
          Length = 534

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LAIVAQWC 9
           LAIV QWC
Sbjct: 303 LAIVTQWC 310
>XP_005265415
          Length = 567

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LAIVAQWC 9
           LAIV QWC
Sbjct: 336 LAIVTQWC 343
>XP_005265414
          Length = 615

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LAIVAQWC 9
           LAIV QWC
Sbjct: 384 LAIVTQWC 391
>XP_005265412
          Length = 648

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LAIVAQWC 9
           LAIV QWC
Sbjct: 417 LAIVTQWC 424
>NP_001007467
          Length = 678

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IVAQWC 9
           +VAQWC
Sbjct: 288 VVAQWC 293
>NP_064630
          Length = 1543

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IVAQWC 9
           +VAQWC
Sbjct: 288 VVAQWC 293
>NP_001243125
          Length = 609

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AIVAQWC 9
           AI+ QWC
Sbjct: 382 AIITQWC 388
>NP_001645
          Length = 606

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AIVAQWC 9
           AI+ QWC
Sbjct: 379 AIITQWC 385
>XP_006724592
          Length = 611

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AIVAQWC 9
           AI+ QWC
Sbjct: 384 AIITQWC 390
>XP_005267114
          Length = 1543

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IVAQWC 9
           +VAQWC
Sbjct: 288 VVAQWC 293
>NP_001011718
          Length = 579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   IVAQWC 9
           IVA WC
Sbjct: 332 IVAHWC 337
>NP_001252
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLAIVAQWC 9
           QLA+++Q C
Sbjct: 237 QLALISQLC 245
>XP_006726390
          Length = 1353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 465 QLAVFFLWC 473
>XP_006726389
          Length = 1471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 583 QLAVFFLWC 591
>XP_006726388
          Length = 1489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 601 QLAVFFLWC 609
>XP_006726387
          Length = 1497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 601 QLAVFFLWC 609
>XP_006711142
          Length = 1471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 583 QLAVFFLWC 591
>XP_006711141
          Length = 1489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 601 QLAVFFLWC 609
>XP_006711140
          Length = 1497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 601 QLAVFFLWC 609
>XP_006710131
          Length = 1353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 465 QLAVFFLWC 473
>XP_006710130
          Length = 1471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 583 QLAVFFLWC 591
>XP_006710129
          Length = 1489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 601 QLAVFFLWC 609
>XP_006710128
          Length = 1497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QLAIVAQWC 9
           QLA+   WC
Sbjct: 601 QLAVFFLWC 609
>NP_689703
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  QLAIVAQW 8
          QLA+  QW
Sbjct: 39 QLALFPQW 46
>NP_001264084
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  QLAIVAQW 8
          QLA+  QW
Sbjct: 80 QLALFPQW 87
>NP_775871
          Length = 8384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4  IVAQWC 9
          +VA WC
Sbjct: 9  VVALWC 14
>XP_005259087
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  AIVAQW 8
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_006723320
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  AIVAQW 8
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_005259086
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  AIVAQW 8
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_006723319
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  AIVAQW 8
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_005259085
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  AIVAQW 8
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_006711813
          Length = 225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  QLAIVAQW 8
          QLA+  QW
Sbjct: 39 QLALFPQW 46
>XP_005273128
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  QLAIVAQW 8
          QLA+  QW
Sbjct: 39 QLALFPQW 46
>XP_006711812
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  QLAIVAQW 8
          QLA+  QW
Sbjct: 39 QLALFPQW 46
>NP_060498
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  AIVAQW 8
          AIV+QW
Sbjct: 66 AIVSQW 71
>NP_001277482
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVAQW 8
           IVAQW
Sbjct: 251 IVAQW 255
>NP_001277486
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVAQW 8
           IVAQW
Sbjct: 251 IVAQW 255
>NP_001277558
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVAQW 8
           IVAQW
Sbjct: 251 IVAQW 255
>NP_057083
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVAQW 8
           IVAQW
Sbjct: 251 IVAQW 255
>NP_660288
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QLAIVAQWC 9
           +LA+V Q C
Sbjct: 418 ELAVVRQQC 426
>NP_077283
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LAIVAQW 8
           LA+V++W
Sbjct: 250 LAVVSKW 256
>NP_001153416
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QLAIVAQWC 9
           +LA+V Q C
Sbjct: 429 ELAVVRQQC 437
>XP_005272515
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QLAIVAQWC 9
           +LA+V Q C
Sbjct: 429 ELAVVRQQC 437
>XP_005253387
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  QLAIVAQW 8
          +LA++ QW
Sbjct: 40 ELAVLYQW 47
>XP_006719103
          Length = 1296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  QLAIVAQW 8
          +LA++ QW
Sbjct: 40 ELAVLYQW 47
>XP_005253383
          Length = 1333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  QLAIVAQW 8
          +LA++ QW
Sbjct: 40 ELAVLYQW 47
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.131    0.536 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 447,302
Number of extensions: 477
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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