Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     509
NP_036462                                                              20     509
NP_001243397                                                           20     509
XP_005269721                                                           20     509
NP_001138537                                                           17    2528
NP_997374                                                              17    2528
NP_683692                                                              17    4312
XP_005248208                                                           17    4312
XP_005248207                                                           17    4312
XP_006714021                                                           17    4312
NP_065853                                                              16    5631
NP_001278340                                                           16    5631
NP_620305                                                              16    5631
NP_115571                                                              16    5631
NP_001171671                                                           16    5631
NP_006768                                                              16    5631
XP_006724107                                                           16    5631
XP_006724106                                                           16    5631
XP_005271684                                                           16    5631
NP_001139                                                              16    7355
XP_006714257                                                           16    7355
XP_005263002                                                           16    7355
XP_005262999                                                           16    7355
XP_006714252                                                           16    7355
XP_006714251                                                           16    7355
XP_006714250                                                           16    7355
NP_705834                                                              16    7355
NP_001240781                                                           15    9605
NP_000029                                                              15    9605
NP_001120983                                                           15    9605
NP_006585                                                              15    9605
NP_001120982                                                           15    9605
NP_001240782                                                           15    9605
NP_003611                                                              15    9605
NP_001182185                                                           15    9605
NP_060952                                                              15    9605
NP_705900                                                              15    9605
NP_055242                                                              15    9605
NP_001073996                                                           15    9605
NP_001234925                                                           15    9605
XP_006716630                                                           15    9605
XP_006716629                                                           15    9605
XP_006716628                                                           15    9605
XP_006716627                                                           15    9605
XP_006716626                                                           15    9605
XP_005250982                                                           15    9605
XP_006712602                                                           15    9605
XP_005270438                                                           15    9605
NP_001036158                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QLAEIPKTS 9
            QLAEIP+TS
Sbjct: 1488 QLAEIPETS 1496
>NP_036462
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QLAEIPKTS 9
            QLAEIP+TS
Sbjct: 1780 QLAEIPETS 1788
>NP_001243397
          Length = 1890

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QLAEIPKTS 9
            QLAEIP+TS
Sbjct: 1597 QLAEIPETS 1605
>XP_005269721
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QLAEIPKTS 9
            QLAEIP+TS
Sbjct: 1780 QLAEIPETS 1788
>NP_001138537
          Length = 900

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLAEIPKTS 9
           Q+AE+P TS
Sbjct: 351 QIAELPATS 359
>NP_997374
          Length = 677

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLAEIPKTS 9
           Q+AE+P TS
Sbjct: 351 QIAELPATS 359
>NP_683692
          Length = 3051

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            L E+PKTS
Sbjct: 2818 LEELPKTS 2825
>XP_005248208
          Length = 3097

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            L E+PKTS
Sbjct: 2818 LEELPKTS 2825
>XP_005248207
          Length = 3098

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            L E+PKTS
Sbjct: 2818 LEELPKTS 2825
>XP_006714021
          Length = 3112

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            L E+PKTS
Sbjct: 2818 LEELPKTS 2825
>NP_065853
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AEIPKT 8
           AEIPKT
Sbjct: 621 AEIPKT 626
>NP_001278340
          Length = 2108

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLAEIPKTS 9
           +L E+PKT+
Sbjct: 360 ELPELPKTT 368
>NP_620305
          Length = 2426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLAEIPKTS 9
           +L E+PKT+
Sbjct: 360 ELPELPKTT 368
>NP_115571
          Length = 2303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLAEIPKTS 9
           +L E+PKT+
Sbjct: 360 ELPELPKTT 368
>NP_001171671
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EIPKTS 9
           EIPKTS
Sbjct: 462 EIPKTS 467
>NP_006768
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EIPKTS 9
           EIPKTS
Sbjct: 462 EIPKTS 467
>XP_006724107
          Length = 2298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLAEIPKTS 9
           +L E+PKT+
Sbjct: 360 ELPELPKTT 368
>XP_006724106
          Length = 2459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QLAEIPKTS 9
           +L E+PKT+
Sbjct: 360 ELPELPKTT 368
>XP_005271684
          Length = 1081

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AEIPKT 8
           AEIPKT
Sbjct: 621 AEIPKT 626
>NP_001139
          Length = 3957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            LAE P+TS
Sbjct: 2236 LAETPETS 2243
>XP_006714257
          Length = 4145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            LAE P+TS
Sbjct: 2245 LAETPETS 2252
>XP_005263002
          Length = 4072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            LAE P+TS
Sbjct: 2203 LAETPETS 2210
>XP_005262999
          Length = 4147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            LAE P+TS
Sbjct: 2247 LAETPETS 2254
>XP_006714252
          Length = 4153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            LAE P+TS
Sbjct: 2253 LAETPETS 2260
>XP_006714251
          Length = 4165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            LAE P+TS
Sbjct: 2265 LAETPETS 2272
>XP_006714250
          Length = 4190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAEIPKTS 9
            LAE P+TS
Sbjct: 2290 LAETPETS 2297
>NP_705834
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AEIPKTS 9
           A IPKTS
Sbjct: 257 ASIPKTS 263
>NP_001240781
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EIPKTS 9
           E+PKTS
Sbjct: 587 ELPKTS 592
>NP_000029
          Length = 2843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    QLAEIPKTS 9
            +L+++P+TS
Sbjct: 2341 KLSQLPRTS 2349
>NP_001120983
          Length = 2825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    QLAEIPKTS 9
            +L+++P+TS
Sbjct: 2323 KLSQLPRTS 2331
>NP_006585
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EIPKTS 9
           E+PKTS
Sbjct: 587 ELPKTS 592
>NP_001120982
          Length = 2843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    QLAEIPKTS 9
            +L+++P+TS
Sbjct: 2341 KLSQLPRTS 2349
>NP_001240782
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EIPKTS 9
           E+PKTS
Sbjct: 488 ELPKTS 493
>NP_003611
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QLAEIPKT 8
           +LAE PKT
Sbjct: 156 KLAEWPKT 163
>NP_001182185
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AEIPKTS 9
           AE+P+TS
Sbjct: 195 AELPETS 201
>NP_060952
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QLAEIPK 7
           QLAE+P+
Sbjct: 926 QLAELPQ 932
>NP_705900
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LAEIPK 7
           LAE+PK
Sbjct: 524 LAEVPK 529
>NP_055242
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LAEIPK 7
           LAE+PK
Sbjct: 599 LAEVPK 604
>NP_001073996
          Length = 2116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    QLAEIPK 7
            QLA +PK
Sbjct: 1949 QLASVPK 1955
>NP_001234925
          Length = 1122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QLAEIPK 7
           QLAE+P+
Sbjct: 919 QLAELPQ 925
>XP_006716630
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QLAEIPK 7
           QLAE+P+
Sbjct: 870 QLAELPQ 876
>XP_006716629
          Length = 1075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QLAEIPK 7
           QLAE+P+
Sbjct: 872 QLAELPQ 878
>XP_006716628
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QLAEIPK 7
           QLAE+P+
Sbjct: 873 QLAELPQ 879
>XP_006716627
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QLAEIPK 7
           QLAE+P+
Sbjct: 922 QLAELPQ 928
>XP_006716626
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QLAEIPK 7
           QLAE+P+
Sbjct: 929 QLAELPQ 935
>XP_005250982
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QLAEIPK 7
           QLAE+P+
Sbjct: 929 QLAELPQ 935
>XP_006712602
          Length = 2142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    QLAEIPK 7
            QLA +PK
Sbjct: 1975 QLASVPK 1981
>XP_005270438
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EIPKTS 9
           E+PKTS
Sbjct: 483 ELPKTS 488
>NP_001036158
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AEIPKTS 9
           AE+PK S
Sbjct: 125 AEVPKVS 131
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.117    0.291 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 664,766
Number of extensions: 636
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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