Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000512                                                              19     869
NP_443179                                                              18    1135
XP_005266703                                                           18    1135
NP_000740                                                              17    3301
NP_037517                                                              17    3301
XP_006718995                                                           17    4312
XP_005274425                                                           17    4312
XP_006718994                                                           17    4312
XP_006718993                                                           17    4312
XP_005274424                                                           17    4312
XP_005274423                                                           17    4312
NP_203753                                                              17    4312
NP_006333                                                              16    5631
NP_001979                                                              16    5631
XP_005247987                                                           16    5631
XP_006713918                                                           16    5631
XP_005247986                                                           16    5631
NP_001239264                                                           16    7355
NP_060887                                                              16    7355
NP_001161221                                                           16    7355
NP_003591                                                              16    7355
NP_940838                                                              16    7355
NP_940837                                                              16    7355
NP_940839                                                              16    7355
NP_940835                                                              16    7355
NP_940836                                                              16    7355
NP_078887                                                              16    7355
NP_001018099                                                           16    7355
NP_001171455                                                           16    7355
NP_055006                                                              16    7355
NP_060269                                                              16    7355
NP_116255                                                              16    7355
XP_006723935                                                           16    7355
XP_005260591                                                           16    7355
XP_006723934                                                           16    7355
XP_005254784                                                           16    7355
XP_005254783                                                           16    7355
XP_005254720                                                           16    7355
XP_005254719                                                           16    7355
XP_005254718                                                           16    7355
XP_006720240                                                           16    7355
XP_006720238                                                           16    7355
XP_006719619                                                           16    7355
XP_005245387                                                           16    7355
XP_005245386                                                           16    7355
XP_006711512                                                           16    7355
NP_694948                                                              16    7355
NP_001164168                                                           15    9605
NP_001158238                                                           15    9605
NP_001164167                                                           15    9605
NP_001164169                                                           15    9605
NP_115987                                                              15    9605
NP_001164170                                                           15    9605
NP_001164166                                                           15    9605
NP_054730                                                              15    9605
NP_008816                                                              15    9605
XP_005256887                                                           15    9605
XP_006721654                                                           15    9605
XP_006721653                                                           15    9605
XP_006721652                                                           15    9605
XP_005256886                                                           15    9605
XP_005256885                                                           15    9605
XP_005256014                                                           15    9605
NP_659198                                                              15    9605
>NP_000512
          Length = 556

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QKQKQLSIG 9
           QKQKQL IG
Sbjct: 475 QKQKQLFIG 483
>NP_443179
          Length = 2170

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QKQKQLSIG 9
            QKQKQ SIG
Sbjct: 2138 QKQKQPSIG 2146
>XP_005266703
          Length = 1501

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QKQKQLSIG 9
            QKQKQ SIG
Sbjct: 1469 QKQKQPSIG 1477
>NP_000740
          Length = 458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QKQKQLSIG 9
           +KQKQLS G
Sbjct: 376 KKQKQLSDG 384
>NP_037517
          Length = 394

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QKQKQLSIG 9
          QK+K+L IG
Sbjct: 60 QKEKELCIG 68
>XP_006718995
          Length = 2382

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           QKQKQL +
Sbjct: 285 QKQKQLEL 292
>XP_005274425
          Length = 2566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           QKQKQL +
Sbjct: 518 QKQKQLEL 525
>XP_006718994
          Length = 2567

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           QKQKQL +
Sbjct: 518 QKQKQLEL 525
>XP_006718993
          Length = 2602

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           QKQKQL +
Sbjct: 518 QKQKQLEL 525
>XP_005274424
          Length = 2614

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           QKQKQL +
Sbjct: 518 QKQKQLEL 525
>XP_005274423
          Length = 2615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           QKQKQL +
Sbjct: 518 QKQKQLEL 525
>NP_203753
          Length = 2601

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           QKQKQL +
Sbjct: 518 QKQKQLEL 525
>NP_006333
          Length = 838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           QKQK+LS
Sbjct: 691 QKQKELS 697
>NP_001979
          Length = 2033

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QKQKQLSIG 9
           QKQKQ+  G
Sbjct: 158 QKQKQVCAG 166
>XP_005247987
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           QKQK+LS
Sbjct: 335 QKQKELS 341
>XP_006713918
          Length = 830

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           QKQK+LS
Sbjct: 683 QKQKELS 689
>XP_005247986
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           QKQK+LS
Sbjct: 695 QKQKELS 701
>NP_001239264
          Length = 1302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           Q+QKQLS
Sbjct: 913 QEQKQLS 919
>NP_060887
          Length = 1610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           +KQKQL I
Sbjct: 617 KKQKQLEI 624
>NP_001161221
          Length = 1457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           +KQKQL I
Sbjct: 464 KKQKQLEI 471
>NP_003591
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 74 QKQKQL 79
>NP_940838
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 74 QKQKQL 79
>NP_940837
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 74 QKQKQL 79
>NP_940839
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 74 QKQKQL 79
>NP_940835
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 74 QKQKQL 79
>NP_940836
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 74 QKQKQL 79
>NP_078887
          Length = 982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QKQKQLSIG 9
           QK+KQL  G
Sbjct: 465 QKEKQLVTG 473
>NP_001018099
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QKQKQLSIG 9
           QK+KQL  G
Sbjct: 328 QKEKQLVTG 336
>NP_001171455
          Length = 1939

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QKQKQLSIG 9
           +KQK+LS G
Sbjct: 498 RKQKELSEG 506
>NP_055006
          Length = 1980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QKQKQLSIG 9
           +KQK+LS G
Sbjct: 498 RKQKELSEG 506
>NP_060269
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KQKQLSIG 9
           K+K+LS+G
Sbjct: 210 KKKELSLG 217
>NP_116255
          Length = 1302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           Q+QKQLS
Sbjct: 913 QEQKQLS 919
>XP_006723935
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 74 QKQKQL 79
>XP_005260591
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 74 QKQKQL 79
>XP_006723934
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  QKQKQL 6
          QKQKQL
Sbjct: 90 QKQKQL 95
>XP_005254784
          Length = 1303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           Q+QKQLS
Sbjct: 913 QEQKQLS 919
>XP_005254783
          Length = 1303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           Q+QKQLS
Sbjct: 913 QEQKQLS 919
>XP_005254720
          Length = 772

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QKQKQLSIG 9
           QK+KQL  G
Sbjct: 465 QKEKQLVTG 473
>XP_005254719
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QKQKQLSIG 9
           QK+KQL  G
Sbjct: 328 QKEKQLVTG 336
>XP_005254718
          Length = 982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QKQKQLSIG 9
           QK+KQL  G
Sbjct: 465 QKEKQLVTG 473
>XP_006720240
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KQKQLSIG 9
           K+K+LS+G
Sbjct: 210 KKKELSLG 217
>XP_006720238
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KQKQLSIG 9
           K+K+LS+G
Sbjct: 210 KKKELSLG 217
>XP_006719619
          Length = 1980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QKQKQLSIG 9
           +KQK+LS G
Sbjct: 498 RKQKELSEG 506
>XP_005245387
          Length = 1203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           +KQKQL I
Sbjct: 617 KKQKQLEI 624
>XP_005245386
          Length = 1518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           +KQKQL I
Sbjct: 525 KKQKQLEI 532
>XP_006711512
          Length = 1547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           +KQKQL I
Sbjct: 617 KKQKQLEI 624
>NP_694948
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KQKQLSIG 9
           +QK+LS+G
Sbjct: 134 RQKRLSLG 141
>NP_001164168
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 153 QQQKQLRI 160
>NP_001158238
          Length = 2789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+Q QLSI
Sbjct: 939 QQQNQLSI 946
>NP_001164167
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 110 QQQKQLRI 117
>NP_001164169
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 153 QQQKQLRI 160
>NP_115987
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 153 QQQKQLRI 160
>NP_001164170
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 153 QQQKQLRI 160
>NP_001164166
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 153 QQQKQLRI 160
>NP_054730
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KQKQLSIG 9
          K+K +SIG
Sbjct: 41 KEKNISIG 48

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           QKQ+Q+S
Sbjct: 338 QKQRQIS 344
>NP_008816
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QKQKQLSI 8
            Q+Q QLSI
Sbjct: 1853 QQQNQLSI 1860
>XP_005256887
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 137 QQQKQLRI 144
>XP_006721654
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 137 QQQKQLRI 144
>XP_006721653
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 137 QQQKQLRI 144
>XP_006721652
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 140 QQQKQLRI 147
>XP_005256886
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 153 QQQKQLRI 160
>XP_005256885
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QKQKQLSI 8
           Q+QKQL I
Sbjct: 156 QQQKQLRI 163
>XP_005256014
          Length = 3702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QKQKQLSI 8
            Q+Q QLSI
Sbjct: 1852 QQQNQLSI 1859
>NP_659198
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KQKQLSIG 9
          K+K +SIG
Sbjct: 41 KEKNISIG 48

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QKQKQLS 7
           QKQ+Q+S
Sbjct: 338 QKQRQIS 344
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.122    0.294 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 545,300
Number of extensions: 978
Number of successful extensions: 66
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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