Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              18    1482
NP_002564                                                              17    3301
NP_001139412                                                           17    3301
NP_001139411                                                           17    3301
NP_004930                                                              17    4312
NP_000334                                                              17    4312
NP_001243243                                                           17    4312
NP_003032                                                              16    5631
NP_859070                                                              16    5631
NP_115649                                                              16    5631
NP_671766                                                              16    5631
NP_671756                                                              16    5631
NP_001072993                                                           16    5631
NP_003734                                                              16    5631
NP_001231664                                                           16    5631
XP_006721136                                                           16    5631
XP_006721135                                                           16    5631
XP_006714098                                                           16    5631
XP_006712189                                                           16    5631
XP_005264685                                                           16    5631
XP_005264684                                                           16    5631
XP_005264683                                                           16    5631
XP_005264682                                                           16    5631
XP_005245884                                                           16    5631
XP_005245882                                                           16    5631
XP_006710614                                                           16    5631
XP_005245881                                                           16    5631
XP_005245880                                                           16    5631
XP_006710613                                                           16    5631
XP_005245879                                                           16    5631
NP_001072992                                                           16    5631
NP_006443                                                              16    5631
NP_075573                                                              16    7355
NP_075571                                                              16    7355
NP_001001991                                                           16    7355
NP_001269605                                                           16    7355
NP_056245                                                              16    7355
NP_001269604                                                           16    7355
NP_066973                                                              16    7355
NP_001171545                                                           16    7355
XP_005268816                                                           16    7355
XP_005268815                                                           16    7355
XP_005268814                                                           16    7355
XP_005268813                                                           16    7355
XP_005268812                                                           16    7355
XP_005268811                                                           16    7355
NP_001075224                                                           15    9605
NP_001265844                                                           15    9605
NP_000492                                                              15    9605
NP_001265842                                                           15    9605
NP_001265846                                                           15    9605
NP_001265843                                                           15    9605
NP_001265868                                                           15    9605
NP_079095                                                              15    9605
NP_001275584                                                           15    9605
NP_001275583                                                           15    9605
NP_001122103                                                           15    9605
XP_005257745                                                           15    9605
XP_006722156                                                           15    9605
XP_006722155                                                           15    9605
XP_006722154                                                           15    9605
XP_006715941                                                           15    9605
XP_006715939                                                           15    9605
XP_006715937                                                           15    9605
XP_005250245                                                           15    9605
XP_005250244                                                           15    9605
NP_149059                                                              15    9605
>NP_002430
          Length = 1137

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QITGGIAAR 9
            QIT GIAAR
Sbjct: 1058 QITRGIAAR 1066
>NP_002564
          Length = 231

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QITGGIAA 8
           Q+TGGI A
Sbjct: 112 QVTGGIKA 119
>NP_001139412
          Length = 231

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QITGGIAA 8
           Q+TGGI A
Sbjct: 112 QVTGGIKA 119
>NP_001139411
          Length = 231

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QITGGIAA 8
           Q+TGGI A
Sbjct: 112 QVTGGIKA 119
>NP_004930
          Length = 740

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ITGGIAAR 9
           I GG+AAR
Sbjct: 323 IIGGVAAR 330
>NP_000334
          Length = 664

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           ITGG+AA
Sbjct: 193 ITGGLAA 199
>NP_001243243
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          ITGG+AA
Sbjct: 66 ITGGLAA 72
>NP_003032
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 190 VTGGLAA 196
>NP_859070
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 206 VTGGLAA 212
>NP_115649
          Length = 195

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITGGIAAR 9
           + GG+AAR
Sbjct: 125 VNGGLAAR 132
>NP_671766
          Length = 1440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           Q+T G+A R
Sbjct: 492 QVTSGLATR 500
>NP_671756
          Length = 1399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           Q+T G+A R
Sbjct: 492 QVTSGLATR 500
>NP_001072993
          Length = 432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  QITGGIAAR 9
          QIT G AAR
Sbjct: 38 QITAGNAAR 46
>NP_003734
          Length = 1441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           Q+T G+A R
Sbjct: 492 QVTSGLATR 500
>NP_001231664
          Length = 125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ITGGIAAR 9
          + GG+AAR
Sbjct: 55 VNGGLAAR 62
>XP_006721136
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 178 VTGGLAA 184
>XP_006721135
          Length = 698

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 190 VTGGLAA 196
>XP_006714098
          Length = 836

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           QIT G AAR
Sbjct: 449 QITAGNAAR 457
>XP_006712189
          Length = 1394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           Q+T G+A R
Sbjct: 445 QVTSGLATR 453
>XP_005264685
          Length = 1399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           Q+T G+A R
Sbjct: 492 QVTSGLATR 500
>XP_005264684
          Length = 1399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           Q+T G+A R
Sbjct: 492 QVTSGLATR 500
>XP_005264683
          Length = 1440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           Q+T G+A R
Sbjct: 492 QVTSGLATR 500
>XP_005264682
          Length = 1441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QITGGIAAR 9
           Q+T G+A R
Sbjct: 492 QVTSGLATR 500
>XP_005245884
          Length = 594

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 206 VTGGLAA 212
>XP_005245882
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 206 VTGGLAA 212
>XP_006710614
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 206 VTGGLAA 212
>XP_005245881
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 206 VTGGLAA 212
>XP_005245880
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 206 VTGGLAA 212
>XP_006710613
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 206 VTGGLAA 212
>XP_005245879
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITGGIAA 8
           +TGG+AA
Sbjct: 206 VTGGLAA 212
>NP_001072992
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  QITGGIAAR 9
          QIT G AAR
Sbjct: 38 QITAGNAAR 46
>NP_006443
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  QITGGIAAR 9
          QIT G AAR
Sbjct: 38 QITAGNAAR 46
>NP_075573
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITGGIAAR 9
           +TGG+A R
Sbjct: 177 LTGGLAER 184
>NP_075571
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITGGIAAR 9
           +TGG+A R
Sbjct: 177 LTGGLAER 184
>NP_001001991
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TGGIAA 8
           TGGIAA
Sbjct: 665 TGGIAA 670
>NP_001269605
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TGGIAA 8
           TGGIAA
Sbjct: 554 TGGIAA 559
>NP_056245
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TGGIAA 8
           TGGIAA
Sbjct: 682 TGGIAA 687
>NP_001269604
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TGGIAA 8
           TGGIAA
Sbjct: 625 TGGIAA 630
>NP_066973
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GGIAAR 9
          GGIAAR
Sbjct: 86 GGIAAR 91
>NP_001171545
          Length = 1061

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GGIAAR 9
          GGIAAR
Sbjct: 86 GGIAAR 91
>XP_005268816
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GGIAAR 9
          GGIAAR
Sbjct: 87 GGIAAR 92
>XP_005268815
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GGIAAR 9
          GGIAAR
Sbjct: 87 GGIAAR 92
>XP_005268814
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GGIAAR 9
          GGIAAR
Sbjct: 60 GGIAAR 65
>XP_005268813
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GGIAAR 9
          GGIAAR
Sbjct: 87 GGIAAR 92
>XP_005268812
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GGIAAR 9
          GGIAAR
Sbjct: 87 GGIAAR 92
>XP_005268811
          Length = 1129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GGIAAR 9
          GGIAAR
Sbjct: 87 GGIAAR 92
>NP_001075224
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 676 GGVAAR 681
>NP_001265844
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 701 GGVAAR 706
>NP_000492
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 695 GGVAAR 700
>NP_001265842
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 614 GGVAAR 619
>NP_001265846
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 685 GGVAAR 690
>NP_001265843
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 671 GGVAAR 676
>NP_001265868
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 757 GGVAAR 762
>NP_079095
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          +TGGIA+
Sbjct: 6  LTGGIAS 12
>NP_001275584
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          +TGGIA+
Sbjct: 6  LTGGIAS 12
>NP_001275583
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          +TGGIA+
Sbjct: 6  LTGGIAS 12
>NP_001122103
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          +TGGIA+
Sbjct: 6  LTGGIAS 12
>XP_005257745
          Length = 132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          +TGGIA+
Sbjct: 6  LTGGIAS 12
>XP_006722156
          Length = 132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          +TGGIA+
Sbjct: 6  LTGGIAS 12
>XP_006722155
          Length = 132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          +TGGIA+
Sbjct: 6  LTGGIAS 12
>XP_006722154
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ITGGIAA 8
          +TGGIA+
Sbjct: 6  LTGGIAS 12
>XP_006715941
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 527 GGVAAR 532
>XP_006715939
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 658 GGVAAR 663
>XP_006715937
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 677 GGVAAR 682
>XP_005250245
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 681 GGVAAR 686
>XP_005250244
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGIAAR 9
           GG+AAR
Sbjct: 683 GGVAAR 688
>NP_149059
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QITGGI 6
           Q+TGGI
Sbjct: 256 QLTGGI 261
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.138    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 510,686
Number of extensions: 471
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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