Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     509
NP_036462                                                              20     509
NP_001243397                                                           20     509
XP_005269721                                                           20     509
NP_001271165                                                           17    3301
NP_001098721                                                           17    3301
NP_055548                                                              17    3301
NP_001271166                                                           17    3301
XP_005248691                                                           17    3301
XP_005248689                                                           17    3301
NP_001017963                                                           17    4312
NP_005339                                                              17    4312
NP_689935                                                              16    5631
NP_038203                                                              16    5631
NP_002152                                                              16    5631
NP_849144                                                              16    5631
XP_005271506                                                           16    5631
XP_006718849                                                           16    5631
XP_006713662                                                           16    5631
XP_006713661                                                           16    5631
XP_006713660                                                           16    5631
XP_005247434                                                           16    5631
XP_006713659                                                           16    5631
NP_001186104                                                           16    7355
NP_001186102                                                           16    7355
NP_071767                                                              16    7355
NP_001186103                                                           16    7355
NP_055816                                                              16    7355
NP_001157994                                                           16    7355
XP_005255537                                                           16    7355
XP_005255536                                                           16    7355
XP_005255535                                                           16    7355
XP_005255533                                                           16    7355
XP_005255532                                                           16    7355
NP_796377                                                              16    7355
NP_002567                                                              15    9605
NP_001122092                                                           15    9605
NP_001035111                                                           15    9605
NP_542970                                                              15    9605
NP_001035112                                                           15    9605
NP_002568                                                              15    9605
NP_002569                                                              15    9605
NP_001121645                                                           15    9605
NP_001121644                                                           15    9605
NP_001121640                                                           15    9605
NP_001121639                                                           15    9605
NP_001121638                                                           15    9605
NP_009211                                                              15    9605
NP_065880                                                              15    9605
NP_001129392                                                           15    9605
NP_001193486                                                           15    9605
XP_005262190                                                           15    9605
XP_006724719                                                           15    9605
XP_006724718                                                           15    9605
XP_006724717                                                           15    9605
XP_005262189                                                           15    9605
XP_006723610                                                           15    9605
XP_006723609                                                           15    9605
XP_006723608                                                           15    9605
XP_005260727                                                           15    9605
XP_005260726                                                           15    9605
XP_006718639                                                           15    9605
XP_006718638                                                           15    9605
XP_006718637                                                           15    9605
XP_006718636                                                           15    9605
XP_005274082                                                           15    9605
XP_006718635                                                           15    9605
XP_005251580                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QISPDQSVI 9
            QISPDQS I
Sbjct: 1336 QISPDQSAI 1344
>NP_036462
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QISPDQSVI 9
            QISPDQS I
Sbjct: 1628 QISPDQSAI 1636
>NP_001243397
          Length = 1890

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QISPDQSVI 9
            QISPDQS I
Sbjct: 1445 QISPDQSAI 1453
>XP_005269721
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QISPDQSVI 9
            QISPDQS I
Sbjct: 1628 QISPDQSAI 1636
>NP_001271165
          Length = 1539

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QISPDQSVI 9
           +I PDQ+VI
Sbjct: 455 KIDPDQTVI 463
>NP_001098721
          Length = 1539

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QISPDQSVI 9
           +I PDQ+VI
Sbjct: 455 KIDPDQTVI 463
>NP_055548
          Length = 1539

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QISPDQSVI 9
           +I PDQ+VI
Sbjct: 455 KIDPDQTVI 463
>NP_001271166
          Length = 809

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QISPDQSVI 9
           +I PDQ+VI
Sbjct: 455 KIDPDQTVI 463
>XP_005248691
          Length = 816

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QISPDQSVI 9
           +I PDQ+VI
Sbjct: 455 KIDPDQTVI 463
>XP_005248689
          Length = 1539

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QISPDQSVI 9
           +I PDQ+VI
Sbjct: 455 KIDPDQTVI 463
>NP_001017963
          Length = 854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QISPDQSVI 9
           +I+PD S+I
Sbjct: 757 EINPDHSII 765
>NP_005339
          Length = 732

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QISPDQSVI 9
           +I+PD S+I
Sbjct: 635 EINPDHSII 643
>NP_689935
          Length = 416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ISPDQSVI 9
           +SPDQ V+
Sbjct: 195 LSPDQKVL 202
>NP_038203
          Length = 1262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISPDQSVI 9
           ++PDQS++
Sbjct: 975 VTPDQSMV 982
>NP_002152
          Length = 1262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISPDQSVI 9
           ++PDQS++
Sbjct: 975 VTPDQSMV 982
>NP_849144
          Length = 2623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ISPDQS 7
            ISPDQS
Sbjct: 1360 ISPDQS 1365
>XP_005271506
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ISPDQSVI 9
           +SPDQ V+
Sbjct: 195 LSPDQKVL 202
>XP_006718849
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ISPDQSVI 9
           +SPDQ V+
Sbjct: 195 LSPDQKVL 202
>XP_006713662
          Length = 1846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ISPDQS 7
            ISPDQS
Sbjct: 1432 ISPDQS 1437
>XP_006713661
          Length = 1860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ISPDQS 7
            ISPDQS
Sbjct: 1432 ISPDQS 1437
>XP_006713660
          Length = 2623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ISPDQS 7
            ISPDQS
Sbjct: 1360 ISPDQS 1365
>XP_005247434
          Length = 2623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ISPDQS 7
            ISPDQS
Sbjct: 1360 ISPDQS 1365
>XP_006713659
          Length = 2695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ISPDQS 7
            ISPDQS
Sbjct: 1432 ISPDQS 1437
>NP_001186104
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  QISPDQSVI 9
          +++PD+S+I
Sbjct: 48 EVTPDRSMI 56
>NP_001186102
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  QISPDQSVI 9
          +++PD+S+I
Sbjct: 49 EVTPDRSMI 57
>NP_071767
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  QISPDQSVI 9
          +++PD+S+I
Sbjct: 49 EVTPDRSMI 57
>NP_001186103
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  QISPDQSVI 9
          +++PD+S+I
Sbjct: 49 EVTPDRSMI 57
>NP_055816
          Length = 3664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ISPDQSVI 9
            I P+QSVI
Sbjct: 3071 IHPEQSVI 3078
>NP_001157994
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           ++SPDQS
Sbjct: 188 KLSPDQS 194
>XP_005255537
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  QISPDQSVI 9
          +++PD+S+I
Sbjct: 49 EVTPDRSMI 57
>XP_005255536
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  QISPDQSVI 9
          +++PD+S+I
Sbjct: 49 EVTPDRSMI 57
>XP_005255535
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  QISPDQSVI 9
          +++PD+S+I
Sbjct: 49 EVTPDRSMI 57
>XP_005255533
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   QISPDQSVI 9
           +++PD+S+I
Sbjct: 120 EVTPDRSMI 128
>XP_005255532
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   QISPDQSVI 9
           +++PD+S+I
Sbjct: 120 EVTPDRSMI 128
>NP_796377
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           ++SPDQS
Sbjct: 188 KLSPDQS 194
>NP_002567
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 413 QITPEQS 419
>NP_001122092
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 413 QITPEQS 419
>NP_001035111
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISPDQSVI 9
          I PD+SV+
Sbjct: 37 IQPDKSVL 44
>NP_542970
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISPDQSVI 9
          I PD+SV+
Sbjct: 37 IQPDKSVL 44
>NP_001035112
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISPDQSVI 9
          I PD+SV+
Sbjct: 37 IQPDKSVL 44
>NP_002568
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 392 QITPEQS 398
>NP_002569
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 411 QITPEQS 417
>NP_001121645
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 426 QITPEQS 432
>NP_001121644
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 432 QITPEQS 438
>NP_001121640
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 447 QITPEQS 453
>NP_001121639
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 411 QITPEQS 417
>NP_001121638
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 411 QITPEQS 417
>NP_009211
          Length = 229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           +++PDQS
Sbjct: 219 EVTPDQS 225
>NP_065880
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SPDQSVI 9
           SPD SV+
Sbjct: 315 SPDNSVV 321
>NP_001129392
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SPDQSVI 9
           SPD SV+
Sbjct: 315 SPDNSVV 321
>NP_001193486
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SPDQSVI 9
           SPD SV+
Sbjct: 315 SPDNSVV 321
>XP_005262190
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 411 QITPEQS 417
>XP_006724719
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 426 QITPEQS 432
>XP_006724718
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 426 QITPEQS 432
>XP_006724717
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 426 QITPEQS 432
>XP_005262189
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 426 QITPEQS 432
>XP_006723610
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISPDQSVI 9
          I PD+SV+
Sbjct: 37 IQPDKSVL 44
>XP_006723609
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISPDQSVI 9
          I PD+SV+
Sbjct: 37 IQPDKSVL 44
>XP_006723608
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISPDQSVI 9
          I PD+SV+
Sbjct: 37 IQPDKSVL 44
>XP_005260727
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISPDQSVI 9
          I PD+SV+
Sbjct: 37 IQPDKSVL 44
>XP_005260726
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISPDQSVI 9
          I PD+SV+
Sbjct: 37 IQPDKSVL 44
>XP_006718639
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 413 QITPEQS 419
>XP_006718638
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 413 QITPEQS 419
>XP_006718637
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 413 QITPEQS 419
>XP_006718636
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 413 QITPEQS 419
>XP_005274082
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 413 QITPEQS 419
>XP_006718635
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QISPDQS 7
           QI+P+QS
Sbjct: 475 QITPEQS 481
>XP_005251580
          Length = 1422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SPDQSVI 9
           SPD SV+
Sbjct: 314 SPDNSVV 320
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.127    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 714,663
Number of extensions: 925
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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