Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_038479                                                              17    2528
NP_579899                                                              17    2528
NP_001098714                                                           17    2528
XP_006722401                                                           17    2528
XP_006722400                                                           17    2528
XP_006722399                                                           17    2528
XP_006722398                                                           17    2528
XP_006717823                                                           17    2528
XP_005269751                                                           17    2528
XP_005269750                                                           17    2528
NP_002836                                                              17    2528
NP_001171826                                                           17    4312
NP_001171889                                                           17    4312
NP_055922                                                              17    4312
NP_001171825                                                           17    4312
NP_114098                                                              17    4312
NP_695001                                                              17    4312
NP_055864                                                              17    4312
NP_001171827                                                           17    4312
NP_001019837                                                           17    4312
NP_542138                                                              17    4312
XP_006724648                                                           17    4312
XP_005262057                                                           17    4312
XP_005262055                                                           17    4312
XP_005262056                                                           17    4312
XP_005262054                                                           17    4312
XP_005262053                                                           17    4312
XP_005274553                                                           17    4312
XP_005274552                                                           17    4312
XP_005274551                                                           17    4312
XP_005260723                                                           17    4312
XP_006723606                                                           17    4312
XP_006712777                                                           17    4312
NP_003290                                                              16    5631
NP_877416                                                              16    5631
NP_001186916                                                           16    5631
NP_002484                                                              16    5631
NP_005393                                                              16    7355
NP_060208                                                              16    7355
NP_036395                                                              16    7355
NP_085150                                                              16    7355
XP_006724288                                                           16    7355
XP_006717206                                                           16    7355
XP_005252108                                                           16    7355
XP_006716856                                                           16    7355
XP_005251549                                                           16    7355
XP_006715826                                                           16    7355
XP_006715825                                                           16    7355
XP_005245830                                                           16    7355
XP_005245829                                                           16    7355
NP_005383                                                              16    7355
NP_006333                                                              15    9605
NP_001180211                                                           15    9605
NP_005723                                                              15    9605
NP_001138600                                                           15    9605
NP_002797                                                              15    9605
NP_663780                                                              15    9605
NP_056101                                                              15    9605
NP_057257                                                              15    9605
NP_003159                                                              15    9605
NP_060417                                                              15    9605
XP_005257084                                                           15    9605
XP_006715439                                                           15    9605
XP_006713948                                                           15    9605
XP_005247987                                                           15    9605
XP_006713918                                                           15    9605
XP_005247986                                                           15    9605
XP_005265275                                                           15    9605
>NP_038479
          Length = 2061

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           QIR+LRSR
Sbjct: 721 QIRKLRSR 728
>NP_579899
          Length = 2048

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           QIR+LRSR
Sbjct: 708 QIRKLRSR 715
>NP_001098714
          Length = 1465

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IRELRSRK 9
            +RELRSR+
Sbjct: 1140 VRELRSRR 1147
>XP_006722401
          Length = 1432

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IRELRSRK 9
            +RELRSR+
Sbjct: 1107 VRELRSRR 1114
>XP_006722400
          Length = 1469

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IRELRSRK 9
            +RELRSR+
Sbjct: 1144 VRELRSRR 1151
>XP_006722399
          Length = 1477

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IRELRSRK 9
            +RELRSR+
Sbjct: 1152 VRELRSRR 1159
>XP_006722398
          Length = 1494

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IRELRSRK 9
            +RELRSR+
Sbjct: 1169 VRELRSRR 1176
>XP_006717823
          Length = 1938

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           QIR+LRSR
Sbjct: 579 QIRKLRSR 586
>XP_005269751
          Length = 2067

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           QIR+LRSR
Sbjct: 708 QIRKLRSR 715
>XP_005269750
          Length = 2080

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           QIR+LRSR
Sbjct: 721 QIRKLRSR 728
>NP_002836
          Length = 1452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IRELRSRK 9
            +RELRSR+
Sbjct: 1127 VRELRSRR 1134
>NP_001171826
          Length = 948

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          +RELRSR
Sbjct: 88 VRELRSR 94
>NP_001171889
          Length = 427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIRELRS 7
           Q+RELRS
Sbjct: 377 QVRELRS 383
>NP_055922
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          +RELRSR
Sbjct: 88 VRELRSR 94
>NP_001171825
          Length = 1060

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRELRSR 8
           +RELRSR
Sbjct: 124 VRELRSR 130
>NP_114098
          Length = 665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIRELRS 7
           Q+RELRS
Sbjct: 615 QVRELRS 621
>NP_695001
          Length = 363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IRELRSRK 9
           +RELRSR+
Sbjct: 112 LRELRSRE 119
>NP_055864
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           +I+ELRSR
Sbjct: 346 EIKELRSR 353
>NP_001171827
          Length = 878

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          +RELRSR
Sbjct: 88 VRELRSR 94
>NP_001019837
          Length = 628

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIRELRS 7
           Q+RELRS
Sbjct: 578 QVRELRS 584
>NP_542138
          Length = 362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IRELRSRK 9
           +RELRSR+
Sbjct: 111 LRELRSRE 118
>XP_006724648
          Length = 931

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRELRSR 8
           +RELRSR
Sbjct: 124 VRELRSR 130
>XP_005262057
          Length = 984

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRELRSR 8
           +RELRSR
Sbjct: 124 VRELRSR 130
>XP_005262055
          Length = 1049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          +RELRSR
Sbjct: 88 VRELRSR 94
>XP_005262056
          Length = 1049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          +RELRSR
Sbjct: 88 VRELRSR 94
>XP_005262054
          Length = 1049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          +RELRSR
Sbjct: 88 VRELRSR 94
>XP_005262053
          Length = 1085

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRELRSR 8
           +RELRSR
Sbjct: 124 VRELRSR 130
>XP_005274553
          Length = 647

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIRELRS 7
           Q+RELRS
Sbjct: 597 QVRELRS 603
>XP_005274552
          Length = 653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIRELRS 7
           Q+RELRS
Sbjct: 603 QVRELRS 609
>XP_005274551
          Length = 690

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIRELRS 7
           Q+RELRS
Sbjct: 640 QVRELRS 646
>XP_005260723
          Length = 279

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  IRELRSRK 9
          +RELRSR+
Sbjct: 77 LRELRSRE 84
>XP_006723606
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  IRELRSRK 9
          +RELRSR+
Sbjct: 59 LRELRSRE 66
>XP_006712777
          Length = 703

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           +I+ELRSR
Sbjct: 135 EIKELRSR 142
>NP_003290
          Length = 803

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QIRELRSR 8
          QIRELR +
Sbjct: 65 QIRELREK 72
>NP_877416
          Length = 113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QIRELRSR 8
          Q+RELR R
Sbjct: 14 QLRELRRR 21
>NP_001186916
          Length = 97

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QIRELRSR 8
          Q+RELR R
Sbjct: 14 QLRELRRR 21
>NP_002484
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QIRELRSR 8
          Q+RELR R
Sbjct: 14 QLRELRRR 21
>NP_005393
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IRELRSRK 9
           +RE+R+RK
Sbjct: 172 MREIRARK 179
>NP_060208
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QIRELRSRK 9
            QIREL+  K
Sbjct: 1301 QIRELKKMK 1309
>NP_036395
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RELRSRK 9
           RELRSR+
Sbjct: 394 RELRSRQ 400
>NP_085150
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRELRSR 8
           I+ELRSR
Sbjct: 123 IKELRSR 129
>XP_006724288
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RELRSRK 9
           RELRSR+
Sbjct: 297 RELRSRQ 303
>XP_006717206
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          I+ELRSR
Sbjct: 90 IKELRSR 96
>XP_005252108
          Length = 1097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          I+ELRSR
Sbjct: 90 IKELRSR 96
>XP_006716856
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QIRELRSRK 9
            QIREL+  K
Sbjct: 1238 QIRELKKMK 1246
>XP_005251549
          Length = 1405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QIRELRSRK 9
            QIREL+  K
Sbjct: 1300 QIRELKKMK 1308
>XP_006715826
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IRELRSRK 9
           +RE+R+RK
Sbjct: 172 MREIRARK 179
>XP_006715825
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IRELRSRK 9
           +RE+R+RK
Sbjct: 172 MREIRARK 179
>XP_005245830
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           Q+RELR++
Sbjct: 771 QLRELRAK 778
>XP_005245829
          Length = 787

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           Q+RELR++
Sbjct: 776 QLRELRAK 783
>NP_005383
          Length = 1096

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRELRSR 8
          I+ELRSR
Sbjct: 90 IKELRSR 96
>NP_006333
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELRSR 8
           RELRSR
Sbjct: 656 RELRSR 661
>NP_001180211
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QIRELRSRK 9
           ++RE RSRK
Sbjct: 399 RLREDRSRK 407
>NP_005723
          Length = 1312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QIRELRSR 8
           QIR+++SR
Sbjct: 551 QIRKIKSR 558
>NP_001138600
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IRELRSRK 9
           +REL++RK
Sbjct: 458 LRELQARK 465
>NP_002797
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QIRELR 6
           QIRELR
Sbjct: 155 QIRELR 160
>NP_663780
          Length = 1565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IRELRSR 8
           +RELR+R
Sbjct: 152 VRELRAR 158
>NP_056101
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IRELRSR 8
           +RELR+R
Sbjct: 152 VRELRAR 158
>NP_057257
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IRELRSRK 9
           IREL SR+
Sbjct: 97  IRELSSRR 104
>NP_003159
          Length = 117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IRELRSR 8
           +REL+SR
Sbjct: 98  VRELKSR 104
>NP_060417
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IRELRSRK 9
          +RELR+R+
Sbjct: 35 LRELRARE 42
>XP_005257084
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QIRELRSRK 9
          QIR  RSR+
Sbjct: 26 QIRRTRSRE 34
>XP_006715439
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IRELRSRK 9
           +REL++RK
Sbjct: 458 LRELQARK 465
>XP_006713948
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QIRELRSRK 9
           ++RE RSRK
Sbjct: 400 RLREDRSRK 408
>XP_005247987
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELRSR 8
           RELRSR
Sbjct: 300 RELRSR 305
>XP_006713918
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELRSR 8
           RELRSR
Sbjct: 648 RELRSR 653
>XP_005247986
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RELRSR 8
           RELRSR
Sbjct: 660 RELRSR 665
>XP_005265275
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IRELRSRK 9
           IREL SR+
Sbjct: 97  IRELSSRR 104
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.135    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 458,137
Number of extensions: 902
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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