Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_001165783                                                           17    2528
NP_002661                                                              17    2528
NP_001138791                                                           17    2528
XP_006713725                                                           17    2528
XP_006713724                                                           17    2528
XP_006713723                                                           17    2528
NP_001158202                                                           17    3301
NP_075063                                                              17    3301
NP_001158204                                                           17    3301
XP_006712141                                                           17    3301
XP_005264562                                                           17    3301
XP_005264560                                                           17    3301
XP_005264559                                                           17    3301
NP_203754                                                              17    4312
XP_006718789                                                           17    4312
XP_006718788                                                           17    4312
XP_005274419                                                           17    4312
XP_005264132                                                           17    4312
NP_056988                                                              17    4312
NP_056023                                                              16    5631
NP_001190985                                                           16    5631
NP_001231611                                                           16    5631
NP_001077094                                                           16    5631
NP_078964                                                              16    5631
NP_055167                                                              16    5631
XP_006722380                                                           16    5631
XP_005258153                                                           16    5631
XP_005258152                                                           16    5631
XP_005258151                                                           16    5631
XP_005258150                                                           16    5631
XP_005258149                                                           16    5631
XP_005252650                                                           16    5631
XP_006717569                                                           16    5631
XP_006717568                                                           16    5631
XP_006717567                                                           16    5631
NP_000072                                                              16    7355
NP_001005191                                                           16    7355
NP_001138883                                                           16    7355
XP_006714236                                                           16    7355
XP_005262948                                                           16    7355
XP_006714235                                                           16    7355
XP_006711794                                                           16    7355
XP_005273086                                                           16    7355
XP_005273085                                                           16    7355
XP_005273084                                                           16    7355
NP_689988                                                              16    7355
NP_444256                                                              15    9605
NP_444254                                                              15    9605
NP_444253                                                              15    9605
NP_444255                                                              15    9605
NP_079021                                                              15    9605
NP_001137502                                                           15    9605
XP_005253056                                                           15    9605
XP_005247551                                                           15    9605
XP_005247550                                                           15    9605
XP_006713712                                                           15    9605
XP_005247549                                                           15    9605
XP_005263696                                                           15    9605
NP_078938                                                              15    9605
NP_055255                                                              15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QIKSKDISE 9
            QIKS+DISE
Sbjct: 2292 QIKSRDISE 2300
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QIKSKDISE 9
            QIKS+DISE
Sbjct: 2087 QIKSRDISE 2095
>NP_001165783
          Length = 629

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  QIKSKDISE 9
          ++KSKDIS+
Sbjct: 82 ELKSKDISK 90
>NP_002661
          Length = 629

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  QIKSKDISE 9
          ++KSKDIS+
Sbjct: 82 ELKSKDISK 90
>NP_001138791
          Length = 629

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  QIKSKDISE 9
          ++KSKDIS+
Sbjct: 82 ELKSKDISK 90
>XP_006713725
          Length = 629

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  QIKSKDISE 9
          ++KSKDIS+
Sbjct: 82 ELKSKDISK 90
>XP_006713724
          Length = 629

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  QIKSKDISE 9
          ++KSKDIS+
Sbjct: 82 ELKSKDISK 90
>XP_006713723
          Length = 629

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  QIKSKDISE 9
          ++KSKDIS+
Sbjct: 82 ELKSKDISK 90
>NP_001158202
          Length = 208

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IKSKDISE 9
          +KSKDI E
Sbjct: 34 VKSKDIKE 41
>NP_075063
          Length = 201

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IKSKDISE 9
          +KSKDI E
Sbjct: 27 VKSKDIKE 34
>NP_001158204
          Length = 143

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IKSKDISE 9
          +KSKDI E
Sbjct: 27 VKSKDIKE 34
>XP_006712141
          Length = 139

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IKSKDISE 9
          +KSKDI E
Sbjct: 27 VKSKDIKE 34
>XP_005264562
          Length = 213

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IKSKDISE 9
          +KSKDI E
Sbjct: 27 VKSKDIKE 34
>XP_005264560
          Length = 272

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IKSKDISE 9
          +KSKDI E
Sbjct: 27 VKSKDIKE 34
>XP_005264559
          Length = 284

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IKSKDISE 9
          +KSKDI E
Sbjct: 27 VKSKDIKE 34
>NP_203754
          Length = 1729

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IKSKDISE 9
            +KSKD++E
Sbjct: 1233 VKSKDLAE 1240
>XP_006718789
          Length = 1053

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IKSKDISE 9
           +KSKD++E
Sbjct: 557 VKSKDLAE 564
>XP_006718788
          Length = 1729

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IKSKDISE 9
            +KSKD++E
Sbjct: 1233 VKSKDLAE 1240
>XP_005274419
          Length = 1808

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IKSKDISE 9
            +KSKD++E
Sbjct: 1312 VKSKDLAE 1319
>XP_005264132
          Length = 1219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QIKSKDISE 9
           Q++SK++SE
Sbjct: 457 QLESKEVSE 465
>NP_056988
          Length = 1220

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QIKSKDISE 9
           Q++SK++SE
Sbjct: 457 QLESKEVSE 465
>NP_056023
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 827 QIKEKDIEK 835
>NP_001190985
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 804 QIKEKDIEK 812
>NP_001231611
          Length = 438

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  QIKSKDISE 9
          QIK++D+S+
Sbjct: 46 QIKTEDLSD 54
>NP_001077094
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 804 QIKEKDIEK 812
>NP_078964
          Length = 628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIKSKDIS 8
           +IK KDIS
Sbjct: 238 EIKKKDIS 245
>NP_055167
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  QIKSKDISE 9
          QIK++D+S+
Sbjct: 44 QIKTEDLSD 52
>XP_006722380
          Length = 1769

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 534 QIKEKDIEK 542
>XP_005258153
          Length = 2037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 802 QIKEKDIEK 810
>XP_005258152
          Length = 2060

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 825 QIKEKDIEK 833
>XP_005258151
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 827 QIKEKDIEK 835
>XP_005258150
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 827 QIKEKDIEK 835
>XP_005258149
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK KDI +
Sbjct: 827 QIKEKDIEK 835
>XP_005252650
          Length = 692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIKSKDIS 8
           +IK KDIS
Sbjct: 238 EIKKKDIS 245
>XP_006717569
          Length = 1278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIKSKDIS 8
           +IK KDIS
Sbjct: 824 EIKKKDIS 831
>XP_006717568
          Length = 1314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIKSKDIS 8
           +IK KDIS
Sbjct: 860 EIKKKDIS 867
>XP_006717567
          Length = 1385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIKSKDIS 8
           +IK KDIS
Sbjct: 931 EIKKKDIS 938
>NP_000072
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KSKDISE 9
            KSKDIS+
Sbjct: 2879 KSKDISK 2885
>NP_001005191
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QIKSKDIS 8
          Q +SKDIS
Sbjct: 86 QARSKDIS 93
>NP_001138883
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IKSKDISE 9
           IKSK ISE
Sbjct: 270 IKSKRISE 277
>XP_006714236
          Length = 771

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IKSKDISE 9
           IKSK ISE
Sbjct: 237 IKSKRISE 244
>XP_005262948
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IKSKDISE 9
           IKSK ISE
Sbjct: 307 IKSKRISE 314
>XP_006714235
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IKSKDISE 9
           IKSK ISE
Sbjct: 307 IKSKRISE 314
>XP_006711794
          Length = 3022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KSKDISE 9
            KSKDIS+
Sbjct: 2100 KSKDISK 2106
>XP_005273086
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KSKDISE 9
            KSKDIS+
Sbjct: 2879 KSKDISK 2885
>XP_005273085
          Length = 3755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KSKDISE 9
            KSKDIS+
Sbjct: 2833 KSKDISK 2839
>XP_005273084
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KSKDISE 9
            KSKDIS+
Sbjct: 2879 KSKDISK 2885
>NP_689988
          Length = 833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IKSKDISE 9
           IKSK ISE
Sbjct: 307 IKSKRISE 314
>NP_444256
          Length = 1794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           Q+K K +SE
Sbjct: 863 QVKPKTVSE 871
>NP_444254
          Length = 1845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           Q+K K +SE
Sbjct: 863 QVKPKTVSE 871
>NP_444253
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           Q+K K +SE
Sbjct: 932 QVKPKTVSE 940
>NP_444255
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           Q+K K +SE
Sbjct: 932 QVKPKTVSE 940
>NP_079021
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           QIK K +SE
Sbjct: 627 QIKKKRLSE 635
>NP_001137502
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIKSKDISE 9
           ++KS D+SE
Sbjct: 882 KLKSMDLSE 890
>XP_005253056
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIKSKDISE 9
           ++KS D+SE
Sbjct: 954 KLKSMDLSE 962
>XP_005247551
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           Q+K K +SE
Sbjct: 873 QVKPKTVSE 881
>XP_005247550
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           Q+K K +SE
Sbjct: 942 QVKPKTVSE 950
>XP_006713712
          Length = 1923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           Q+K K +SE
Sbjct: 942 QVKPKTVSE 950
>XP_005247549
          Length = 1924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIKSKDISE 9
           Q+K K +SE
Sbjct: 942 QVKPKTVSE 950
>XP_005263696
          Length = 158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QIKSKDISE 9
          Q+K KDI +
Sbjct: 86 QLKEKDIMD 94
>NP_078938
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIKSKDISE 9
           ++KS D+SE
Sbjct: 954 KLKSMDLSE 962
>NP_055255
          Length = 158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QIKSKDISE 9
          Q+K KDI +
Sbjct: 86 QLKEKDIMD 94
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.116    0.259 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 487,210
Number of extensions: 754
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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