Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001265546                                                           18    1935
NP_001265545                                                           18    1935
NP_004327                                                              18    1935
NP_060678                                                              17    4312
XP_005245359                                                           17    4312
NP_001166176                                                           16    5631
NP_001036024                                                           16    5631
NP_001409                                                              16    5631
NP_006064                                                              16    5631
XP_006715381                                                           16    5631
XP_006715380                                                           16    5631
XP_006715379                                                           16    5631
XP_006715378                                                           16    5631
XP_006715377                                                           16    5631
XP_006715376                                                           16    5631
XP_006715375                                                           16    5631
XP_006715374                                                           16    5631
XP_006715373                                                           16    5631
XP_006715372                                                           16    5631
XP_006715371                                                           16    5631
XP_006715370                                                           16    5631
XP_006715369                                                           16    5631
XP_006715368                                                           16    5631
XP_006715367                                                           16    5631
XP_006715366                                                           16    5631
XP_006715365                                                           16    5631
XP_006715364                                                           16    5631
XP_006715363                                                           16    5631
XP_006715362                                                           16    5631
NP_000073                                                              16    7355
NP_001007234                                                           16    7355
NP_001277214                                                           16    7355
NP_001258358                                                           16    7355
NP_001258357                                                           16    7355
NP_055862                                                              16    7355
NP_001258356                                                           16    7355
NP_055030                                                              16    7355
XP_005245845                                                           16    7355
XP_005245844                                                           16    7355
NP_001156909                                                           15    9605
NP_149106                                                              15    9605
NP_001156908                                                           15    9605
NP_001277697                                                           15    9605
NP_001156907                                                           15    9605
NP_112506                                                              15    9605
NP_065871                                                              15    9605
NP_005522                                                              15    9605
NP_001193496                                                           15    9605
NP_058633                                                              15    9605
XP_006724562                                                           15    9605
XP_005274609                                                           15    9605
XP_005260528                                                           15    9605
XP_005260706                                                           15    9605
XP_005260703                                                           15    9605
XP_005260702                                                           15    9605
XP_006719746                                                           15    9605
XP_005253685                                                           15    9605
XP_005253684                                                           15    9605
XP_006711353                                                           15    9605
XP_005245184                                                           15    9605
NP_003950                                                              15    9605
NP_004308                                                              15    9605
>NP_001265546
          Length = 1028

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QIKSEVNPA 9
           Q +SEVNPA
Sbjct: 315 QERSEVNPA 323
>NP_001265545
          Length = 1065

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QIKSEVNPA 9
           Q +SEVNPA
Sbjct: 295 QERSEVNPA 303
>NP_004327
          Length = 1085

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QIKSEVNPA 9
           Q +SEVNPA
Sbjct: 315 QERSEVNPA 323
>NP_060678
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IKSEVNPA 9
           +K+E+NP+
Sbjct: 207 VKNEINPS 214
>XP_005245359
          Length = 394

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IKSEVNPA 9
           +K+E+NP+
Sbjct: 207 VKNEINPS 214
>NP_001166176
          Length = 907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IKSEVNP 8
           I SEVNP
Sbjct: 780 ISSEVNP 786
>NP_001036024
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IKSEVNP 8
           I SEVNP
Sbjct: 742 ISSEVNP 748
>NP_001409
          Length = 907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IKSEVNP 8
           I SEVNP
Sbjct: 780 ISSEVNP 786
>NP_006064
          Length = 729

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 525 QIKKEAKPA 533
>XP_006715381
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 525 QIKKEAKPA 533
>XP_006715380
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 235 QIKKEAKPA 243
>XP_006715379
          Length = 448

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 244 QIKKEAKPA 252
>XP_006715378
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 245 QIKKEAKPA 253
>XP_006715377
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 496 QIKKEAKPA 504
>XP_006715376
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 497 QIKKEAKPA 505
>XP_006715375
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 526 QIKKEAKPA 534
>XP_006715374
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 505 QIKKEAKPA 513
>XP_006715373
          Length = 714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 526 QIKKEAKPA 534
>XP_006715372
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 526 QIKKEAKPA 534
>XP_006715371
          Length = 718

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 514 QIKKEAKPA 522
>XP_006715370
          Length = 719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 515 QIKKEAKPA 523
>XP_006715369
          Length = 720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 516 QIKKEAKPA 524
>XP_006715368
          Length = 727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 523 QIKKEAKPA 531
>XP_006715367
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 524 QIKKEAKPA 532
>XP_006715366
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 524 QIKKEAKPA 532
>XP_006715365
          Length = 729

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 526 QIKKEAKPA 534
>XP_006715364
          Length = 729

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 526 QIKKEAKPA 534
>XP_006715363
          Length = 729

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 525 QIKKEAKPA 533
>XP_006715362
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QIKSEVNPA 9
           QIK E  PA
Sbjct: 526 QIKKEAKPA 534
>NP_000073
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KSEVNPA 9
           KS++NPA
Sbjct: 378 KSQLNPA 384
>NP_001007234
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KSEVNPA 9
           KS++NPA
Sbjct: 320 KSQLNPA 326
>NP_001277214
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KSEVNPA 9
           KS++NPA
Sbjct: 225 KSQLNPA 231
>NP_001258358
          Length = 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           QIK+E+N
Sbjct: 493 QIKNEIN 499
>NP_001258357
          Length = 992

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           QIK+E+N
Sbjct: 514 QIKNEIN 520
>NP_055862
          Length = 993

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           QIK+E+N
Sbjct: 515 QIKNEIN 521
>NP_001258356
          Length = 992

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           QIK+E+N
Sbjct: 514 QIKNEIN 520
>NP_055030
          Length = 1297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QIKSEVNP 8
           Q K+E+NP
Sbjct: 466 QNKAEINP 473
>XP_005245845
          Length = 995

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           QIK+E+N
Sbjct: 517 QIKNEIN 523
>XP_005245844
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           QIK+E+N
Sbjct: 518 QIKNEIN 524
>NP_001156909
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IKSEVNP 8
           +KSEV+P
Sbjct: 716 LKSEVSP 722
>NP_149106
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IKSEVNP 8
           +KSEV+P
Sbjct: 692 LKSEVSP 698
>NP_001156908
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IKSEVNP 8
           +KSEV+P
Sbjct: 755 LKSEVSP 761
>NP_001277697
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IKSEVNP 8
           +KSEV+P
Sbjct: 583 LKSEVSP 589
>NP_001156907
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IKSEVNP 8
           +KSEV+P
Sbjct: 755 LKSEVSP 761
>NP_112506
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QIKSEVNP 8
          Q+K EV+P
Sbjct: 44 QLKPEVSP 51
>NP_065871
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QIKSEVNP 8
           Q+KS V+P
Sbjct: 943 QLKSRVSP 950
>NP_005522
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QIKSEVNP 8
           QIK + NP
Sbjct: 387 QIKKKTNP 394
>NP_001193496
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QIKSEVNP 8
           QIK + NP
Sbjct: 331 QIKKKTNP 338
>NP_058633
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QIKSEVN 7
            ++KSEVN
Sbjct: 1024 KVKSEVN 1030
>XP_006724562
          Length = 1326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           ++KSEVN
Sbjct: 888 KVKSEVN 894
>XP_005274609
          Length = 1468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QIKSEVN 7
            ++KSEVN
Sbjct: 1030 KVKSEVN 1036
>XP_005260528
          Length = 956

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QIKSEVNP 8
           Q+KS V+P
Sbjct: 240 QLKSRVSP 247
>XP_005260706
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QIKSEVNP 8
          Q+K EV+P
Sbjct: 61 QLKPEVSP 68
>XP_005260703
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QIKSEVNP 8
          Q+K EV+P
Sbjct: 61 QLKPEVSP 68
>XP_005260702
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QIKSEVNP 8
          Q+K EV+P
Sbjct: 61 QLKPEVSP 68
>XP_006719746
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           Q+KS+VN
Sbjct: 371 QLKSQVN 377
>XP_005253685
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           Q+KS+VN
Sbjct: 376 QLKSQVN 382
>XP_005253684
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           Q+KS+VN
Sbjct: 388 QLKSQVN 394
>XP_006711353
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QIKSEVNP 8
           QIK + NP
Sbjct: 391 QIKKKTNP 398
>XP_005245184
          Length = 789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QIKSEVNP 8
           QIK + NP
Sbjct: 391 QIKKKTNP 398
>NP_003950
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIKSEVN 7
           Q+KS+VN
Sbjct: 383 QLKSQVN 389
>NP_004308
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QIKSEVNP 8
           QIK++++P
Sbjct: 192 QIKNQISP 199
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.115    0.291 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 619,911
Number of extensions: 1016
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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