Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
NP_065188                                                              18    1482
NP_001027566                                                           18    1482
NP_001027567                                                           18    1482
NP_940971                                                              18    1482
XP_005267118                                                           18    1482
XP_006715581                                                           18    1482
XP_006715580                                                           18    1482
XP_006715579                                                           18    1482
NP_003052                                                              17    3301
NP_004516                                                              17    4312
NP_001035110                                                           17    4312
NP_000582                                                              17    4312
NP_001167576                                                           17    4312
NP_001167575                                                           17    4312
NP_003957                                                              17    4312
XP_006714571                                                           17    4312
XP_006714570                                                           17    4312
XP_006714569                                                           17    4312
XP_006712591                                                           17    4312
XP_006712590                                                           17    4312
XP_006712589                                                           17    4312
NP_003848                                                              16    5631
NP_004220                                                              16    5631
NP_631906                                                              16    5631
XP_005272758                                                           16    5631
XP_005272757                                                           16    5631
XP_005272756                                                           16    5631
NP_000328                                                              16    7355
NP_001121681                                                           16    7355
NP_758447                                                              16    7355
NP_002833                                                              16    7355
NP_002259                                                              16    7355
NP_002258                                                              16    7355
XP_006723375                                                           16    7355
XP_005266024                                                           16    7355
XP_006714975                                                           16    7355
XP_006714974                                                           16    7355
XP_005266023                                                           16    7355
XP_005266022                                                           16    7355
NP_077288                                                              15    9605
NP_005553                                                              15    9605
NP_005996                                                              15    9605
NP_001139325                                                           15    9605
NP_061486                                                              15    9605
NP_001154912                                                           15    9605
NP_001087                                                              15    9605
NP_942127                                                              15    9605
NP_004817                                                              15    9605
NP_001277716                                                           15    9605
NP_001189479                                                           15    9605
NP_001093591                                                           15    9605
NP_001093590                                                           15    9605
NP_001009562                                                           15    9605
XP_005257452                                                           15    9605
XP_005257451                                                           15    9605
XP_005257450                                                           15    9605
XP_006719656                                                           15    9605
XP_006711379                                                           15    9605
XP_005245207                                                           15    9605
NP_001032401                                                           15    9605
NP_055508                                                              15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QIANLTVDG 9
            QIANLTV G
Sbjct: 2555 QIANLTVAG 2563
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QIANLTVDG 9
            QIANLTV G
Sbjct: 2350 QIANLTVAG 2358
>NP_065188
          Length = 1221

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           QI NLT DG
Sbjct: 590 QILNLTADG 598
>NP_001027566
          Length = 1193

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           QI NLT DG
Sbjct: 562 QILNLTADG 570
>NP_001027567
          Length = 1222

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           QI NLT DG
Sbjct: 562 QILNLTADG 570
>NP_940971
          Length = 1250

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           QI NLT DG
Sbjct: 590 QILNLTADG 598
>XP_005267118
          Length = 1222

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           QI NLT DG
Sbjct: 591 QILNLTADG 599
>XP_006715581
          Length = 1223

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           QI NLT DG
Sbjct: 563 QILNLTADG 571
>XP_006715580
          Length = 1249

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           QI NLT DG
Sbjct: 589 QILNLTADG 597
>XP_006715579
          Length = 1251

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           QI NLT DG
Sbjct: 591 QILNLTADG 599
>NP_003052
          Length = 1534

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QIANLTVDG 9
            Q+ NL++DG
Sbjct: 1256 QMVNLSIDG 1264
>NP_004516
          Length = 4655

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IANLTVDG 9
            + NLT+DG
Sbjct: 3209 LRNLTIDG 3216
>NP_001035110
          Length = 375

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIANLTVDG 9
           ++ NLT+DG
Sbjct: 320 EVDNLTLDG 328
>NP_000582
          Length = 375

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIANLTVDG 9
           ++ NLT+DG
Sbjct: 320 EVDNLTLDG 328
>NP_001167576
          Length = 375

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIANLTVDG 9
           ++ NLT+DG
Sbjct: 320 EVDNLTLDG 328
>NP_001167575
          Length = 375

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIANLTVDG 9
           ++ NLT+DG
Sbjct: 320 EVDNLTLDG 328
>NP_003957
          Length = 1074

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           NLTVDG
Sbjct: 536 NLTVDG 541
>XP_006714571
          Length = 917

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           NLTVDG
Sbjct: 379 NLTVDG 384
>XP_006714570
          Length = 1074

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           NLTVDG
Sbjct: 536 NLTVDG 541
>XP_006714569
          Length = 1074

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           NLTVDG
Sbjct: 536 NLTVDG 541
>XP_006712591
          Length = 3308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IANLTVDG 9
            + NLT+DG
Sbjct: 3214 LRNLTIDG 3221
>XP_006712590
          Length = 3897

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IANLTVDG 9
            + NLT+DG
Sbjct: 2451 LRNLTIDG 2458
>XP_006712589
          Length = 4660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IANLTVDG 9
            + NLT+DG
Sbjct: 3214 LRNLTIDG 3221
>NP_003848
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+ANLTV
Sbjct: 168 QLANLTV 174
>NP_004220
          Length = 1454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+ANLTV
Sbjct: 211 QLANLTV 217
>NP_631906
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N TVDG
Sbjct: 72 KVMNFTVDG 80
>XP_005272758
          Length = 1338

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+ANLTV
Sbjct: 95  QLANLTV 101
>XP_005272757
          Length = 1410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+ANLTV
Sbjct: 211 QLANLTV 217
>XP_005272756
          Length = 1443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+ANLTV
Sbjct: 211 QLANLTV 217
>NP_000328
          Length = 290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N T+DG
Sbjct: 58 KVMNFTIDG 66
>NP_001121681
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N T+DG
Sbjct: 57 KVMNFTIDG 65
>NP_758447
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N T+DG
Sbjct: 58 KVMNFTIDG 66
>NP_002833
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           N+TVDG
Sbjct: 172 NITVDG 177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NLTVDG 9
          N+TVDG
Sbjct: 83 NVTVDG 88
>NP_002259
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANLTVDG 9
           I+NLT+ G
Sbjct: 392 ISNLTISG 399
>NP_002258
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANLTVDG 9
           I+NLT+ G
Sbjct: 392 ISNLTISG 399
>XP_006723375
          Length = 1137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           N+TVDG
Sbjct: 194 NITVDG 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           N+TVDG
Sbjct: 105 NVTVDG 110
>XP_005266024
          Length = 175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N T+DG
Sbjct: 58 KVMNFTIDG 66
>XP_006714975
          Length = 194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N T+DG
Sbjct: 58 KVMNFTIDG 66
>XP_006714974
          Length = 290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N T+DG
Sbjct: 58 KVMNFTIDG 66
>XP_005266023
          Length = 290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N T+DG
Sbjct: 58 KVMNFTIDG 66
>XP_005266022
          Length = 290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  QIANLTVDG 9
          ++ N T+DG
Sbjct: 58 KVMNFTIDG 66
>NP_077288
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           N+T+DG
Sbjct: 287 NMTIDG 292
>NP_005553
          Length = 1193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANLTVDG 9
            AN+T DG
Sbjct: 1032 ANVTADG 1038
>NP_005996
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IANLTVD 8
           ++NLT+D
Sbjct: 333 VSNLTID 339
>NP_001139325
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IANLTVD 8
           ++NLT+D
Sbjct: 333 VSNLTID 339
>NP_061486
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANLTVDG 9
            AN+T DG
Sbjct: 1032 ANVTADG 1038
>NP_001154912
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NLTVDG 9
          N+TVDG
Sbjct: 83 NVTVDG 88
>NP_001087
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NLTVDG 9
          NLT+DG
Sbjct: 75 NLTLDG 80
>NP_942127
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NLTVDG 9
          NLT+DG
Sbjct: 75 NLTLDG 80
>NP_004817
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+AN+TV
Sbjct: 319 QLANITV 325
>NP_001277716
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+AN+TV
Sbjct: 319 QLANITV 325
>NP_001189479
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QIANLTVDG 9
           Q+A  T+DG
Sbjct: 714 QLATATLDG 722
>NP_001093591
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+AN+TV
Sbjct: 308 QLANITV 314
>NP_001093590
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+AN+TV
Sbjct: 354 QLANITV 360
>NP_001009562
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QIANLT 6
           QIANLT
Sbjct: 260 QIANLT 265
>XP_005257452
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NLTVDG 9
          NLT+DG
Sbjct: 75 NLTLDG 80
>XP_005257451
          Length = 1145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           NLT+DG
Sbjct: 129 NLTLDG 134
>XP_005257450
          Length = 1155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           NLT+DG
Sbjct: 129 NLTLDG 134
>XP_006719656
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   NLTVDG 9
           N+T+DG
Sbjct: 287 NMTIDG 292
>XP_006711379
          Length = 1208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANLTVDG 9
            AN+T DG
Sbjct: 1095 ANVTADG 1101
>XP_005245207
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANLTVDG 9
            AN+T DG
Sbjct: 1095 ANVTADG 1101
>NP_001032401
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+AN+TV
Sbjct: 279 QLANITV 285
>NP_055508
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QIANLTV 7
           Q+AN+TV
Sbjct: 426 QLANITV 432
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.133    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 328,708
Number of extensions: 462
Number of successful extensions: 65
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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