Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              20     390
NP_653080                                                              20     390
XP_005267292                                                           20     390
XP_005267291                                                           20     390
XP_005267290                                                           20     390
NP_005821                                                              17    2528
NP_000101                                                              17    3301
NP_056070                                                              17    3301
NP_001186064                                                           17    3301
NP_004171                                                              17    3301
NP_065811                                                              17    3301
XP_005249023                                                           17    3301
XP_005249022                                                           17    3301
XP_006712712                                                           17    3301
XP_006712711                                                           17    3301
XP_006712710                                                           17    3301
XP_006712709                                                           17    3301
XP_005246268                                                           17    3301
XP_005246267                                                           17    3301
XP_005246265                                                           17    3301
XP_005246264                                                           17    3301
XP_005246263                                                           17    3301
XP_006710460                                                           17    3301
XP_005270619                                                           17    3301
NP_689953                                                              17    4312
NP_775487                                                              16    5631
XP_006715416                                                           16    5631
XP_006715415                                                           16    5631
XP_005266895                                                           16    5631
NP_001230925                                                           16    7355
NP_001073950                                                           16    7355
NP_001027                                                              16    7355
XP_005267232                                                           16    7355
XP_005267230                                                           16    7355
XP_005267229                                                           16    7355
XP_005267228                                                           16    7355
XP_005267227                                                           16    7355
XP_005267226                                                           16    7355
NP_783864                                                              15    9605
NP_060105                                                              15    9605
XP_005274094                                                           15    9605
XP_006718644                                                           15    9605
XP_005274093                                                           15    9605
XP_005274092                                                           15    9605
XP_005262701                                                           15    9605
>NP_005091
          Length = 1782

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QFVRTEET 8
            QFVRTEET
Sbjct: 1560 QFVRTEET 1567
>NP_653080
          Length = 1684

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QFVRTEET 8
            QFVRTEET
Sbjct: 1462 QFVRTEET 1469
>XP_005267292
          Length = 1677

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QFVRTEET 8
            QFVRTEET
Sbjct: 1455 QFVRTEET 1462
>XP_005267291
          Length = 1684

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QFVRTEET 8
            QFVRTEET
Sbjct: 1462 QFVRTEET 1469
>XP_005267290
          Length = 1782

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QFVRTEET 8
            QFVRTEET
Sbjct: 1560 QFVRTEET 1567
>NP_005821
          Length = 395

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  QFVRTEETT 9
          Q VRTEET+
Sbjct: 73 QSVRTEETS 81
>NP_000101
          Length = 1025

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QFVRTEE 7
           QFVRTE+
Sbjct: 407 QFVRTEQ 413
>NP_056070
          Length = 1755

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QFVRTEETT 9
            QF+R EE+T
Sbjct: 1258 QFLRKEEST 1266
>NP_001186064
          Length = 425

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FVRTEET 8
           FV+TEET
Sbjct: 280 FVKTEET 286
>NP_004171
          Length = 425

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FVRTEET 8
           FV+TEET
Sbjct: 280 FVKTEET 286
>NP_065811
          Length = 1572

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QFVRTEET 8
            QF+RTE T
Sbjct: 1116 QFIRTEGT 1123
>XP_005249023
          Length = 1052

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QFVRTEETT 9
           QF+R EE+T
Sbjct: 555 QFLRKEEST 563
>XP_005249022
          Length = 1755

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QFVRTEETT 9
            QF+R EE+T
Sbjct: 1258 QFLRKEEST 1266
>XP_006712712
          Length = 1414

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QFVRTEET 8
           QF+RTE T
Sbjct: 958 QFIRTEGT 965
>XP_006712711
          Length = 1448

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QFVRTEET 8
           QF+RTE T
Sbjct: 992 QFIRTEGT 999
>XP_006712710
          Length = 1528

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QFVRTEET 8
            QF+RTE T
Sbjct: 1123 QFIRTEGT 1130
>XP_006712709
          Length = 1579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QFVRTEET 8
            QF+RTE T
Sbjct: 1123 QFIRTEGT 1130
>XP_005246268
          Length = 426

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FVRTEET 8
           FV+TEET
Sbjct: 281 FVKTEET 287
>XP_005246267
          Length = 426

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FVRTEET 8
           FV+TEET
Sbjct: 281 FVKTEET 287
>XP_005246265
          Length = 484

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FVRTEET 8
           FV+TEET
Sbjct: 339 FVKTEET 345
>XP_005246264
          Length = 532

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FVRTEET 8
           FV+TEET
Sbjct: 387 FVKTEET 393
>XP_005246263
          Length = 533

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FVRTEET 8
           FV+TEET
Sbjct: 388 FVKTEET 394
>XP_006710460
          Length = 889

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QFVRTEE 7
           QFVRTE+
Sbjct: 407 QFVRTEQ 413
>XP_005270619
          Length = 953

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QFVRTEE 7
           QFVRTE+
Sbjct: 407 QFVRTEQ 413
>NP_689953
          Length = 336

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QFVRTEET 8
           QF+R EET
Sbjct: 328 QFLREEET 335
>NP_775487
          Length = 520

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QFVRTEET 8
           Q VRT+ET
Sbjct: 105 QVVRTQET 112
>XP_006715416
          Length = 501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QFVRTEET 8
           +FV++EET
Sbjct: 479 EFVKSEET 486
>XP_006715415
          Length = 501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QFVRTEET 8
           +FV++EET
Sbjct: 479 EFVKSEET 486
>XP_005266895
          Length = 501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QFVRTEET 8
           +FV++EET
Sbjct: 479 EFVKSEET 486
>NP_001230925
          Length = 4865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  QFVRTEE 7
          QF+RTE+
Sbjct: 13 QFLRTED 19
>NP_001073950
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRTEET 8
           VRTEET
Sbjct: 305 VRTEET 310
>NP_001027
          Length = 4870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  QFVRTEE 7
          QF+RTE+
Sbjct: 13 QFLRTED 19
>XP_005267232
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRTEET 8
           VRTEET
Sbjct: 305 VRTEET 310
>XP_005267230
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRTEET 8
           VRTEET
Sbjct: 140 VRTEET 145
>XP_005267229
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRTEET 8
           VRTEET
Sbjct: 305 VRTEET 310
>XP_005267228
          Length = 813

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRTEET 8
           VRTEET
Sbjct: 304 VRTEET 309
>XP_005267227
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRTEET 8
           VRTEET
Sbjct: 305 VRTEET 310
>XP_005267226
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRTEET 8
           VRTEET
Sbjct: 305 VRTEET 310
>NP_783864
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEETT 9
           V+TE+TT
Sbjct: 425 VKTEDTT 431
>NP_060105
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QFVRTEETT 9
           QF + EE+T
Sbjct: 622 QFAKIEEST 630
>XP_005274094
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QFVRTEETT 9
           QF + EE+T
Sbjct: 450 QFAKIEEST 458
>XP_006718644
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QFVRTEETT 9
           QF + EE+T
Sbjct: 599 QFAKIEEST 607
>XP_005274093
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QFVRTEETT 9
           QF + EE+T
Sbjct: 599 QFAKIEEST 607
>XP_005274092
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QFVRTEETT 9
           QF + EE+T
Sbjct: 622 QFAKIEEST 630
>XP_005262701
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEETT 9
           V+TE+TT
Sbjct: 425 VKTEDTT 431
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.119    0.300 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 430,174
Number of extensions: 596
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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