Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              20     299
NP_057043                                                              18    1135
NP_001137484                                                           18    1135
NP_001136336                                                           17    2528
XP_006721417                                                           17    2528
XP_006721416                                                           17    2528
NP_057118                                                              17    3301
XP_006717199                                                           17    3301
NP_690862                                                              17    3301
NP_001268653                                                           17    4312
NP_000051                                                              17    4312
NP_001268654                                                           17    4312
NP_001138985                                                           17    4312
NP_055581                                                              17    4312
NP_001268652                                                           17    4312
NP_001099133                                                           17    4312
NP_001138987                                                           17    4312
NP_001138986                                                           17    4312
NP_001230589                                                           17    4312
NP_001230590                                                           17    4312
XP_005274106                                                           17    4312
XP_005274105                                                           17    4312
XP_005249975                                                           17    4312
XP_006713378                                                           17    4312
XP_006713377                                                           17    4312
XP_005265474                                                           17    4312
NP_056969                                                              17    4312
NP_001268885                                                           16    5631
NP_055426                                                              16    5631
XP_006715468                                                           16    5631
XP_005248756                                                           16    5631
XP_006715467                                                           16    5631
NP_653314                                                              16    7355
NP_000689                                                              16    7355
NP_001243082                                                           16    7355
NP_001269075                                                           16    7355
NP_065793                                                              16    7355
NP_851849                                                              16    7355
NP_001269074                                                           16    7355
NP_065724                                                              16    7355
NP_005236                                                              16    7355
NP_001032                                                              16    7355
NP_001193779                                                           16    7355
NP_055708                                                              16    7355
NP_005473                                                              16    7355
NP_060382                                                              16    7355
NP_001158608                                                           16    7355
XP_006724937                                                           16    7355
XP_005274625                                                           16    7355
XP_006724567                                                           16    7355
XP_005274623                                                           16    7355
XP_005274622                                                           16    7355
XP_005274621                                                           16    7355
XP_005260526                                                           16    7355
XP_006715407                                                           16    7355
XP_005263140                                                           16    7355
XP_006714202                                                           16    7355
XP_005262892                                                           16    7355
XP_005262891                                                           16    7355
XP_006712016                                                           16    7355
NP_001275685                                                           15    9605
NP_060034                                                              15    9605
NP_001028721                                                           15    9605
NP_054892                                                              15    9605
NP_219499                                                              15    9605
NP_004361                                                              15    9605
XP_006719539                                                           15    9605
XP_005250691                                                           15    9605
XP_006715397                                                           15    9605
>NP_004295
          Length = 1620

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QFNLNELFS 9
           QFNL+ELFS
Sbjct: 167 QFNLSELFS 175
>NP_057043
          Length = 296

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QFNLNELF 8
           +FNLNEL+
Sbjct: 254 EFNLNELY 261
>NP_001137484
          Length = 258

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QFNLNELF 8
           +FNLNEL+
Sbjct: 216 EFNLNELY 223
>NP_001136336
          Length = 2521

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QFNLNELFS 9
           QF+++ELFS
Sbjct: 674 QFSVSELFS 682
>XP_006721417
          Length = 2497

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QFNLNELFS 9
           QF+++ELFS
Sbjct: 674 QFSVSELFS 682
>XP_006721416
          Length = 2504

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QFNLNELFS 9
           QF+++ELFS
Sbjct: 657 QFSVSELFS 665
>NP_057118
          Length = 296

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FNLNELFS 9
          FN+ ELFS
Sbjct: 73 FNVKELFS 80
>XP_006717199
          Length = 319

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FNLNELFS 9
           FN+ ELFS
Sbjct: 96  FNVKELFS 103
>NP_690862
          Length = 166

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   FNLNELF 8
           FNLNE F
Sbjct: 115 FNLNEAF 121
>NP_001268653
          Length = 545

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QFNLNELFS 9
           QFN N +FS
Sbjct: 195 QFNTNVVFS 203
>NP_000051
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QFNLNELFS 9
           QFN N +FS
Sbjct: 193 QFNTNVVFS 201
>NP_001268654
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QFNLNELFS 9
           QFN N +FS
Sbjct: 173 QFNTNVVFS 181
>NP_001138985
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QFNLNELFS 9
           +FN +E+FS
Sbjct: 219 EFNFSEVFS 227
>NP_055581
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QFNLNELFS 9
           +FN +E+FS
Sbjct: 219 EFNFSEVFS 227
>NP_001268652
          Length = 545

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QFNLNELFS 9
           QFN N +FS
Sbjct: 195 QFNTNVVFS 203
>NP_001099133
          Length = 238

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QFNLNELFS 9
           QFNLN++ +
Sbjct: 213 QFNLNDVLA 221
>NP_001138987
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QFNLNELFS 9
           +FN +E+FS
Sbjct: 151 EFNFSEVFS 159
>NP_001138986
          Length = 434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QFNLNELFS 9
           +FN +E+FS
Sbjct: 239 EFNFSEVFS 247
>NP_001230589
          Length = 223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QFNLNELFS 9
           QFNLN++ +
Sbjct: 198 QFNLNDVLA 206
>NP_001230590
          Length = 185

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QFNLNELFS 9
           QFNLN++ +
Sbjct: 160 QFNLNDVLA 168
>XP_005274106
          Length = 1685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QFNLNELFS 9
            Q ++NELFS
Sbjct: 1397 QVDVNELFS 1405
>XP_005274105
          Length = 1686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QFNLNELFS 9
            Q ++NELFS
Sbjct: 1397 QVDVNELFS 1405
>XP_005249975
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QFNLNELFS 9
           +FN +E+FS
Sbjct: 219 EFNFSEVFS 227
>XP_006713378
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QFNLNELFS 9
           QFN N +FS
Sbjct: 173 QFNTNVVFS 181
>XP_006713377
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QFNLNELFS 9
           QFN N +FS
Sbjct: 173 QFNTNVVFS 181
>XP_005265474
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QFNLNELFS 9
           QFN N +FS
Sbjct: 173 QFNTNVVFS 181
>NP_056969
          Length = 1555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QFNLNELFS 9
            Q ++NELFS
Sbjct: 1266 QVDVNELFS 1274
>NP_001268885
          Length = 3631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QFNLNEL 7
            QFNLN++
Sbjct: 2812 QFNLNDV 2818
>NP_055426
          Length = 5596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    QFNLNELF 8
            +FNL +LF
Sbjct: 1945 EFNLRDLF 1952
>XP_006715468
          Length = 3744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QFNLNELF 8
           +FNL +LF
Sbjct: 93  EFNLRDLF 100
>XP_005248756
          Length = 3905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QFNLNELF 8
           +FNL +LF
Sbjct: 254 EFNLRDLF 261
>XP_006715467
          Length = 5550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    QFNLNELF 8
            +FNL +LF
Sbjct: 1945 EFNLRDLF 1952
>NP_653314
          Length = 573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FNLNEL 7
           FNLNE+
Sbjct: 154 FNLNEI 159
>NP_000689
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QFNLNELF 8
           QF  NELF
Sbjct: 610 QFQENELF 617
>NP_001243082
          Length = 642

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QFNLNELF 8
           QF  NELF
Sbjct: 578 QFQENELF 585
>NP_001269075
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 599 NLNEIF 604
>NP_065793
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 599 NLNEIF 604
>NP_851849
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 599 NLNEIF 604
>NP_001269074
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 599 NLNEIF 604
>NP_065724
          Length = 194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           N+NELF
Sbjct: 154 NINELF 159
>NP_005236
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QFNLNEL 7
            QF++NEL
Sbjct: 3171 QFSINEL 3177
>NP_001032
          Length = 1827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QFNLNE 6
            QFNLN+
Sbjct: 1744 QFNLNQ 1749
>NP_001193779
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 431 NLNEIF 436
>NP_055708
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 599 NLNEIF 604
>NP_005473
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QFNLNELF 8
           Q N+N+LF
Sbjct: 265 QTNMNDLF 272
>NP_060382
          Length = 1022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FNLNEL 7
           FN+NEL
Sbjct: 584 FNINEL 589
>NP_001158608
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FNLNEL 7
           FN+NEL
Sbjct: 584 FNINEL 589
>XP_006724937
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 619 NLNEIF 624
>XP_005274625
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 619 NLNEIF 624
>XP_006724567
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 619 NLNEIF 624
>XP_005274623
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 619 NLNEIF 624
>XP_005274622
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 619 NLNEIF 624
>XP_005274621
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           NLNE+F
Sbjct: 619 NLNEIF 624
>XP_005260526
          Length = 170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           N+NELF
Sbjct: 130 NINELF 135
>XP_006715407
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NLNELF 8
           N+NELF
Sbjct: 202 NMNELF 207
>XP_005263140
          Length = 1034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FNLNEL 7
           FN+NEL
Sbjct: 596 FNINEL 601
>XP_006714202
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QFNLNEL 7
            QF++NEL
Sbjct: 3171 QFSINEL 3177
>XP_005262892
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QFNLNEL 7
            QF++NEL
Sbjct: 3171 QFSINEL 3177
>XP_005262891
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QFNLNEL 7
            QF++NEL
Sbjct: 3171 QFSINEL 3177
>XP_006712016
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FNLNEL 7
           FNLNE+
Sbjct: 154 FNLNEI 159
>NP_001275685
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   FNLNELFS 9
           FNL  LFS
Sbjct: 181 FNLEGLFS 188
>NP_060034
          Length = 2551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FNLNEL 7
           FN+NEL
Sbjct: 418 FNVNEL 423
>NP_001028721
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   FNLNELFS 9
           FNL  LFS
Sbjct: 181 FNLEGLFS 188
>NP_054892
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   FNLNELFS 9
           FNL  LFS
Sbjct: 181 FNLEGLFS 188
>NP_219499
          Length = 1663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QFNLNELF 8
          +FNLN+ F
Sbjct: 77 RFNLNDPF 84
>NP_004361
          Length = 3063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QFNLNELF 8
           +FNLN+ +
Sbjct: 191 EFNLNQYY 198
>XP_006719539
          Length = 2246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FNLNEL 7
           FN+NEL
Sbjct: 418 FNVNEL 423
>XP_005250691
          Length = 1645

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QFNLNELF 8
          +FNLN+ F
Sbjct: 59 RFNLNDPF 66
>XP_006715397
          Length = 2972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QFNLNELF 8
           +FNLN+ +
Sbjct: 191 EFNLNQYY 198
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.139    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 457,431
Number of extensions: 771
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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