Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1935
XP_005266703                                                           18    1935
NP_055428                                                              17    4312
NP_001139281                                                           16    5631
NP_006725                                                              16    5631
NP_001070654                                                           16    5631
NP_079005                                                              16    5631
XP_006723449                                                           16    5631
XP_005267014                                                           16    5631
NP_055281                                                              16    7355
NP_006314                                                              16    7355
NP_001036199                                                           16    7355
NP_853513                                                              16    7355
XP_005262748                                                           16    7355
XP_005262746                                                           16    7355
XP_005262745                                                           16    7355
XP_005270810                                                           16    7355
NP_079066                                                              15    9605
NP_001278268                                                           15    9605
NP_065769                                                              15    9605
XP_006721134                                                           15    9605
XP_005255507                                                           15    9605
XP_005269164                                                           15    9605
XP_006716540                                                           15    9605
XP_006716539                                                           15    9605
XP_006716538                                                           15    9605
XP_005251368                                                           15    9605
XP_006716537                                                           15    9605
XP_006716536                                                           15    9605
XP_005251364                                                           15    9605
XP_006716535                                                           15    9605
XP_006716534                                                           15    9605
XP_006716533                                                           15    9605
XP_006716532                                                           15    9605
XP_005251363                                                           15    9605
XP_005251362                                                           15    9605
NP_620710                                                              15    9605
NP_003067                                                              15    9605
>NP_443179
          Length = 2170

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEVQQQSLS 9
            Q VQQQSLS
Sbjct: 1135 QGVQQQSLS 1143
>XP_005266703
          Length = 1501

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QEVQQQSLS 9
           Q VQQQSLS
Sbjct: 466 QGVQQQSLS 474
>NP_055428
          Length = 445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QEVQQQSLS 9
           +EVQQQ L+
Sbjct: 323 EEVQQQKLA 331
>NP_001139281
          Length = 2036

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QEVQQQS 7
           QE+QQQS
Sbjct: 923 QELQQQS 929
>NP_006725
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QEVQQQS 7
           Q+VQQQS
Sbjct: 867 QQVQQQS 873
>NP_001070654
          Length = 2003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QEVQQQS 7
           QE+QQQS
Sbjct: 890 QELQQQS 896
>NP_079005
          Length = 1995

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QEVQQQS 7
           QE+QQQS
Sbjct: 882 QELQQQS 888
>XP_006723449
          Length = 2003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QEVQQQS 7
           QE+QQQS
Sbjct: 890 QELQQQS 896
>XP_005267014
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QEVQQQS 7
           Q+VQQQS
Sbjct: 867 QQVQQQS 873
>NP_055281
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QEVQQQ 6
           QEVQQQ
Sbjct: 166 QEVQQQ 171
>NP_006314
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QEVQQQSLS 9
           Q  QQQSLS
Sbjct: 247 QHHQQQSLS 255
>NP_001036199
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QEVQQQSLS 9
           Q  QQQSLS
Sbjct: 247 QHHQQQSLS 255
>NP_853513
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QEVQQQSLS 9
           QE+Q +SLS
Sbjct: 210 QELQYESLS 218
>XP_005262748
          Length = 1263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QEVQQQSLS 9
           Q  QQQSLS
Sbjct: 278 QHHQQQSLS 286
>XP_005262746
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QEVQQQSLS 9
           Q  QQQSLS
Sbjct: 278 QHHQQQSLS 286
>XP_005262745
          Length = 1299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QEVQQQSLS 9
           Q  QQQSLS
Sbjct: 278 QHHQQQSLS 286
>XP_005270810
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QEVQQQ 6
           QEVQQQ
Sbjct: 166 QEVQQQ 171
>NP_079066
          Length = 1221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 1007 EIQQQAL 1013
>NP_001278268
          Length = 876

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EVQQQSL 8
           E+QQQ+L
Sbjct: 662 EIQQQAL 668
>NP_065769
          Length = 1352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QEVQQQSLS 9
           + VQ+QSLS
Sbjct: 839 RSVQRQSLS 847
>XP_006721134
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QEVQQQSLS 9
           + VQ+QSLS
Sbjct: 576 RSVQRQSLS 584
>XP_005255507
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QEVQQQSLS 9
           + VQ+QSLS
Sbjct: 576 RSVQRQSLS 584
>XP_005269164
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QEVQQQSL 8
           Q+VQQQ++
Sbjct: 233 QQVQQQAV 240
>XP_006716540
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EVQQQSL 8
           E+QQQ+L
Sbjct: 865 EIQQQAL 871
>XP_006716539
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 1042 EIQQQAL 1048
>XP_006716538
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EVQQQSL 8
           E+QQQ+L
Sbjct: 956 EIQQQAL 962
>XP_005251368
          Length = 1185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EVQQQSL 8
           E+QQQ+L
Sbjct: 971 EIQQQAL 977
>XP_006716537
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EVQQQSL 8
           E+QQQ+L
Sbjct: 991 EIQQQAL 997
>XP_006716536
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 998  EIQQQAL 1004
>XP_005251364
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 998  EIQQQAL 1004
>XP_006716535
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 1006 EIQQQAL 1012
>XP_006716534
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 1006 EIQQQAL 1012
>XP_006716533
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 1006 EIQQQAL 1012
>XP_006716532
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 1009 EIQQQAL 1015
>XP_005251363
          Length = 1248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 1034 EIQQQAL 1040
>XP_005251362
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EVQQQSL 8
            E+QQQ+L
Sbjct: 1042 EIQQQAL 1048
>NP_620710
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QEVQQQSL 8
           Q+VQQQ++
Sbjct: 109 QQVQQQAV 116
>NP_003067
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QEVQQQSL 8
           Q+VQQQ++
Sbjct: 109 QQVQQQAV 116
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.287    0.100    0.209 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 428,438
Number of extensions: 781
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package