Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     299
NP_001035957                                                           20     299
XP_006721991                                                           20     299
XP_006721990                                                           20     299
XP_006721989                                                           20     299
XP_005258041                                                           20     299
XP_006721988                                                           20     299
XP_006721987                                                           20     299
XP_006721986                                                           20     299
XP_005258040                                                           20     299
XP_006721985                                                           20     299
XP_005276506                                                           19     869
XP_006720412                                                           19     869
NP_056327                                                              18    1935
XP_006713163                                                           18    1935
NP_665798                                                              16    5631
NP_665799                                                              16    5631
NP_665801                                                              16    5631
NP_055944                                                              16    5631
NP_037402                                                              16    5631
XP_006724813                                                           16    5631
XP_006724812                                                           16    5631
XP_006724811                                                           16    5631
XP_005262457                                                           16    5631
NP_689916                                                              16    7355
NP_001193900                                                           16    7355
NP_002828                                                              16    7355
NP_001103224                                                           16    7355
NP_001193901                                                           16    7355
NP_060124                                                              16    7355
NP_997328                                                              16    7355
NP_001035858                                                           16    7355
NP_057206                                                              16    7355
NP_665741                                                              16    7355
NP_001180236                                                           16    7355
XP_005257067                                                           16    7355
XP_006719592                                                           16    7355
XP_006719591                                                           16    7355
XP_005268999                                                           16    7355
XP_006719500                                                           16    7355
XP_006715953                                                           16    7355
XP_006715952                                                           16    7355
XP_005250250                                                           16    7355
XP_006715951                                                           16    7355
XP_005250248                                                           16    7355
XP_006714322                                                           16    7355
XP_005263179                                                           16    7355
XP_005263178                                                           16    7355
XP_005263177                                                           16    7355
NP_060713                                                              16    7355
NP_061198                                                              15    9605
NP_000370                                                              15    9605
XP_005257995                                                           15    9605
XP_005257994                                                           15    9605
XP_006720670                                                           15    9605
XP_006717822                                                           15    9605
XP_006717821                                                           15    9605
XP_005269749                                                           15    9605
XP_006717820                                                           15    9605
XP_005245779                                                           15    9605
XP_005245778                                                           15    9605
XP_005245777                                                           15    9605
XP_005245776                                                           15    9605
XP_005245775                                                           15    9605
XP_005245774                                                           15    9605
NP_065081                                                              15    9605
NP_005830                                                              15    9605
NP_001273                                                              15    9605
NP_001025177                                                           15    9605
>NP_000258
          Length = 2818

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1033 QEMKFRNKM 1041
>NP_001035957
          Length = 2839

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1033 QEMKFRNKM 1041
>XP_006721991
          Length = 1632

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1043 QEMKFRNKM 1051
>XP_006721990
          Length = 2823

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1043 QEMKFRNKM 1051
>XP_006721989
          Length = 2823

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1043 QEMKFRNKM 1051
>XP_005258041
          Length = 2836

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1033 QEMKFRNKM 1041
>XP_006721988
          Length = 2846

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1043 QEMKFRNKM 1051
>XP_006721987
          Length = 2849

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1043 QEMKFRNKM 1051
>XP_006721986
          Length = 2854

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1030 QEMKFRNKM 1038
>XP_005258040
          Length = 2857

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1033 QEMKFRNKM 1041
>XP_006721985
          Length = 2867

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QEMKF NKM
Sbjct: 1043 QEMKFRNKM 1051
>XP_005276506
          Length = 151

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  QEMKFSNKM 9
          +EMKF NKM
Sbjct: 66 REMKFRNKM 74
>XP_006720412
          Length = 128

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  QEMKFSNKM 9
          +EMKF NKM
Sbjct: 43 REMKFRNKM 51
>NP_056327
          Length = 4265

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            +EMKFS K+
Sbjct: 3692 EEMKFSKKL 3700
>XP_006713163
          Length = 4265

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            +EMKFS K+
Sbjct: 3692 EEMKFSKKL 3700
>NP_665798
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 242 EELKIGNKM 250
>NP_665799
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 242 EELKIGNKM 250
>NP_665801
          Length = 429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 242 EELKIGNKM 250
>NP_055944
          Length = 434

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 242 EELKIGNKM 250
>NP_037402
          Length = 385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QEMKFSN 7
           QE+K+SN
Sbjct: 214 QELKYSN 220
>XP_006724813
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 242 EELKIGNKM 250
>XP_006724812
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 242 EELKIGNKM 250
>XP_006724811
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 242 EELKIGNKM 250
>XP_005262457
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 242 EELKIGNKM 250
>NP_689916
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EMKFSNKM 9
           +MKFSN++
Sbjct: 214 KMKFSNEV 221
>NP_001193900
          Length = 1907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QE++FS K+
Sbjct: 1305 QEVEFSRKL 1313
>NP_002828
          Length = 1997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QE++FS K+
Sbjct: 1395 QEVEFSRKL 1403
>NP_001103224
          Length = 2215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QE++FS K+
Sbjct: 1613 QEVEFSRKL 1621
>NP_001193901
          Length = 1907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QE++FS K+
Sbjct: 1305 QEVEFSRKL 1313
>NP_060124
          Length = 1589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EMKFSNKM 9
           +MKFSN++
Sbjct: 212 KMKFSNEV 219
>NP_997328
          Length = 183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QEMKFSNKM 9
          Q+M  SNK+
Sbjct: 85 QQMSLSNKL 93
>NP_001035858
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QEMKFSNKM 9
           +E+K SNK+
Sbjct: 313 KELKHSNKL 321
>NP_057206
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QEMKFSNKM 9
           +E+K SNK+
Sbjct: 313 KELKHSNKL 321
>NP_665741
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QEMKFSNK 8
           Q+MK+ NK
Sbjct: 600 QDMKWKNK 607
>NP_001180236
          Length = 1589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EMKFSNKM 9
           +MKFSN++
Sbjct: 212 KMKFSNEV 219
>XP_005257067
          Length = 729

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QEMKFSNK 8
           Q+MK+ NK
Sbjct: 600 QDMKWKNK 607
>XP_006719592
          Length = 2012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QE++FS K+
Sbjct: 1395 QEVEFSRKL 1403
>XP_006719591
          Length = 2230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QEMKFSNKM 9
            QE++FS K+
Sbjct: 1613 QEVEFSRKL 1621
>XP_005268999
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QEMKFSNKM 9
           +E+K SNK+
Sbjct: 313 KELKHSNKL 321
>XP_006719500
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QEMKFSNKM 9
           +E+K SNK+
Sbjct: 313 KELKHSNKL 321
>XP_006715953
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EMKFSNKM 9
           +MKFSN++
Sbjct: 214 KMKFSNEV 221
>XP_006715952
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EMKFSNKM 9
           +MKFSN++
Sbjct: 214 KMKFSNEV 221
>XP_005250250
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EMKFSNKM 9
           +MKFSN++
Sbjct: 214 KMKFSNEV 221
>XP_006715951
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EMKFSNKM 9
           +MKFSN++
Sbjct: 214 KMKFSNEV 221
>XP_005250248
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EMKFSNKM 9
           +MKFSN++
Sbjct: 214 KMKFSNEV 221
>XP_006714322
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 184 EEVKIGNKM 192
>XP_005263179
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 251 EEVKIGNKM 259
>XP_005263178
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 251 EEVKIGNKM 259
>XP_005263177
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 251 EEVKIGNKM 259
>NP_060713
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QEMKFSNKM 9
           +E+K  NKM
Sbjct: 241 EEVKIGNKM 249
>NP_061198
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QEMKFSNK 8
           QE+ FS+K
Sbjct: 706 QELSFSDK 713
>NP_000370
          Length = 1333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   EMKFSNKM 9
           EMKF N +
Sbjct: 267 EMKFKNML 274
>XP_005257995
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EMKFSNK 8
           EM F+NK
Sbjct: 753 EMNFTNK 759
>XP_005257994
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EMKFSNK 8
           EM F+NK
Sbjct: 753 EMNFTNK 759
>XP_006720670
          Length = 1712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QEMKFSNK 8
           QE+ FS+K
Sbjct: 706 QELSFSDK 713
>XP_006717822
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QEMKFSNK 8
           QE+KF  K
Sbjct: 645 QELKFDEK 652
>XP_006717821
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QEMKFSNK 8
           QE+KF  K
Sbjct: 645 QELKFDEK 652
>XP_005269749
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QEMKFSNK 8
           QE+KF  K
Sbjct: 645 QELKFDEK 652
>XP_006717820
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QEMKFSNK 8
           QE+KF  K
Sbjct: 645 QELKFDEK 652
>XP_005245779
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QEMKFSNK 8
          Q+ +FSNK
Sbjct: 13 QDNRFSNK 20
>XP_005245778
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QEMKFSNK 8
          Q+ +FSNK
Sbjct: 13 QDNRFSNK 20
>XP_005245777
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QEMKFSNK 8
          Q+ +FSNK
Sbjct: 13 QDNRFSNK 20
>XP_005245776
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QEMKFSNK 8
          Q+ +FSNK
Sbjct: 13 QDNRFSNK 20
>XP_005245775
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QEMKFSNK 8
          Q+ +FSNK
Sbjct: 13 QDNRFSNK 20
>XP_005245774
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QEMKFSNK 8
          Q+ +FSNK
Sbjct: 13 QDNRFSNK 20
>NP_065081
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QEMKFSNK 8
           QE+KF  K
Sbjct: 645 QELKFDEK 652
>NP_005830
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  QEMKFSNK 8
          Q+ +FSNK
Sbjct: 13 QDNRFSNK 20
>NP_001273
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EMKFSNK 8
           EM F+NK
Sbjct: 739 EMNFTNK 745
>NP_001025177
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EMKFSNK 8
           EM F+NK
Sbjct: 753 EMNFTNK 759
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.116    0.290 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 450,855
Number of extensions: 822
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package