Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_005249232                                                           17    2528
NP_001185863                                                           17    4312
NP_258261                                                              17    4312
XP_005249527                                                           17    4312
XP_006715303                                                           17    4312
NP_001012745                                                           16    5631
NP_006403                                                              16    5631
NP_001267717                                                           16    5631
NP_149351                                                              16    5631
NP_001267721                                                           16    5631
NP_001267718                                                           16    5631
XP_006717320                                                           16    5631
NP_001892                                                              16    7355
NP_056305                                                              16    7355
NP_653327                                                              16    7355
NP_001186312                                                           16    7355
NP_001186311                                                           16    7355
NP_001186310                                                           16    7355
NP_001186309                                                           16    7355
XP_005265883                                                           16    7355
NP_006647                                                              16    7355
NP_000352                                                              15    9605
NP_542779                                                              15    9605
NP_001161074                                                           15    9605
NP_001161071                                                           15    9605
NP_001161073                                                           15    9605
NP_001161072                                                           15    9605
NP_001009881                                                           15    9605
NP_001273358                                                           15    9605
NP_061905                                                              15    9605
NP_001275537                                                           15    9605
NP_001275536                                                           15    9605
NP_079093                                                              15    9605
NP_056084                                                              15    9605
NP_001120650                                                           15    9605
NP_001275980                                                           15    9605
NP_060203                                                              15    9605
NP_055646                                                              15    9605
NP_001275982                                                           15    9605
NP_001275981                                                           15    9605
NP_150377                                                              15    9605
XP_006721650                                                           15    9605
XP_006720755                                                           15    9605
XP_005266060                                                           15    9605
XP_005272346                                                           15    9605
XP_005272345                                                           15    9605
XP_005272344                                                           15    9605
XP_006713955                                                           15    9605
XP_005272341                                                           15    9605
XP_005272340                                                           15    9605
XP_006713495                                                           15    9605
XP_006711453                                                           15    9605
XP_005270742                                                           15    9605
XP_005270741                                                           15    9605
XP_005270740                                                           15    9605
XP_005270739                                                           15    9605
XP_006710563                                                           15    9605
XP_005270738                                                           15    9605
XP_005270737                                                           15    9605
XP_005270736                                                           15    9605
XP_005270735                                                           15    9605
XP_006710562                                                           15    9605
XP_006710561                                                           15    9605
XP_005270733                                                           15    9605
NP_795370                                                              15    9605
NP_076407                                                              15    9605
NP_003546                                                              15    9605
>XP_005249232
          Length = 189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           ARLCL VS
Sbjct: 95  ARLCLAVS 102
>NP_001185863
          Length = 1492

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ARLCLIV 8
           ARLCL++
Sbjct: 170 ARLCLLI 176
>NP_258261
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ARLCLIV 8
           ARLCL++
Sbjct: 127 ARLCLLI 133
>XP_005249527
          Length = 822

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ARLCLIV 8
           ARLCL++
Sbjct: 170 ARLCLLI 176
>XP_006715303
          Length = 1463

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ARLCLIV 8
           ARLCL++
Sbjct: 170 ARLCLLI 176
>NP_001012745
          Length = 246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QARLCLIVS 9
          +AR C+IVS
Sbjct: 88 EARPCVIVS 96
>NP_006403
          Length = 278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QARLCLIVS 9
          +AR C+IVS
Sbjct: 88 EARPCVIVS 96
>NP_001267717
          Length = 254

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ARLCLI 7
          ARLCLI
Sbjct: 14 ARLCLI 19
>NP_149351
          Length = 269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ARLCLI 7
          ARLCLI
Sbjct: 29 ARLCLI 34
>NP_001267721
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ARLCLI 7
          ARLCLI
Sbjct: 29 ARLCLI 34
>NP_001267718
          Length = 159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ARLCLI 7
          ARLCLI
Sbjct: 29 ARLCLI 34
>XP_006717320
          Length = 301

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ARLCLI 7
          ARLCLI
Sbjct: 61 ARLCLI 66
>NP_001892
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   QARLCLI 7
           Q+RLC++
Sbjct: 233 QSRLCMV 239
>NP_056305
          Length = 1179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLC + S
Sbjct: 681 EARLCYVCS 689
>NP_653327
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ARLCLI 7
           ARLCL+
Sbjct: 186 ARLCLV 191
>NP_001186312
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ARLCLI 7
           ARLCL+
Sbjct: 158 ARLCLV 163
>NP_001186311
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ARLCLI 7
           ARLCL+
Sbjct: 172 ARLCLV 177
>NP_001186310
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ARLCLI 7
           ARLCL+
Sbjct: 175 ARLCLV 180
>NP_001186309
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ARLCLI 7
           ARLCL+
Sbjct: 188 ARLCLV 193
>XP_005265883
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ARLCLI 7
           ARLCL+
Sbjct: 174 ARLCLV 179
>NP_006647
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ARLCLIVS 9
           ARLC I S
Sbjct: 157 ARLCFIYS 164
>NP_000352
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LCL+V+
Sbjct: 524 ASLCLVVA 531
>NP_542779
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ARLCLIVS 9
           ARLC + S
Sbjct: 134 ARLCCVAS 141
>NP_001161074
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ARLCLIVS 9
           ARLC + S
Sbjct: 122 ARLCCVAS 129
>NP_001161071
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ARLCLIVS 9
           ARLC + S
Sbjct: 135 ARLCCVAS 142
>NP_001161073
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ARLCLIVS 9
           ARLC + S
Sbjct: 122 ARLCCVAS 129
>NP_001161072
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ARLCLIVS 9
           ARLC + S
Sbjct: 122 ARLCCVAS 129
>NP_001009881
          Length = 1645

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>NP_001273358
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QARLCL 6
           QARLC+
Sbjct: 627 QARLCV 632
>NP_061905
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QARLCL 6
            QARLC+
Sbjct: 1045 QARLCV 1050
>NP_001275537
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QARLCL 6
            QARLC+
Sbjct: 1068 QARLCV 1073
>NP_001275536
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QARLCL 6
            QARLC+
Sbjct: 1006 QARLCV 1011
>NP_079093
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QARLCL 6
           QARLC+
Sbjct: 987 QARLCV 992
>NP_056084
          Length = 1644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>NP_001120650
          Length = 983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 517 ALLCVIVS 524
>NP_001275980
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 428 ALLCVIVS 435
>NP_060203
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 509 ALLCVIVS 516
>NP_055646
          Length = 2925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RLCLIVS 9
            R CL+VS
Sbjct: 2681 RACLVVS 2687
>NP_001275982
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 428 ALLCVIVS 435
>NP_001275981
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 384 ALLCVIVS 391
>NP_150377
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  ARLCLI 7
          ARLCL+
Sbjct: 8  ARLCLL 13
>XP_006721650
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LCLIVS 9
           LCLI+S
Sbjct: 212 LCLIIS 217
>XP_006720755
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QARLCL 6
           QARLC+
Sbjct: 987 QARLCV 992
>XP_005266060
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  ARLCLI 7
          ARLCL+
Sbjct: 8  ARLCLL 13
>XP_005272346
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 517 ALLCVIVS 524
>XP_005272345
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 517 ALLCVIVS 524
>XP_005272344
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 517 ALLCVIVS 524
>XP_006713955
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 395 ALLCVIVS 402
>XP_005272341
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 428 ALLCVIVS 435
>XP_005272340
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARLCLIVS 9
           A LC+IVS
Sbjct: 447 ALLCVIVS 454
>XP_006713495
          Length = 2969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RLCLIVS 9
            R CL+VS
Sbjct: 2725 RACLVVS 2731
>XP_006711453
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QARLCL 6
           QARLC+
Sbjct: 526 QARLCV 531
>XP_005270742
          Length = 1054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_005270741
          Length = 1054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_005270740
          Length = 1530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_005270739
          Length = 1541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 879 KARLCLFGS 887
>XP_006710563
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 919 KARLCLFGS 927
>XP_005270738
          Length = 1614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_005270737
          Length = 1640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_005270736
          Length = 1647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_005270735
          Length = 1651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_006710562
          Length = 1652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_006710561
          Length = 1652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>XP_005270733
          Length = 1652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QARLCLIVS 9
           +ARLCL  S
Sbjct: 990 KARLCLFGS 998
>NP_795370
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LCLIVS 9
           LCLI+S
Sbjct: 243 LCLIIS 248
>NP_076407
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  ARLCLI 7
          AR+CLI
Sbjct: 54 ARICLI 59
>NP_003546
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LCLIVS 9
           LCLI+S
Sbjct: 212 LCLIIS 217
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.342    0.142    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 521,132
Number of extensions: 522
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package