Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              18    1482
NP_038466                                                              18    1935
NP_444295                                                              18    1935
NP_064516                                                              18    1935
XP_005245404                                                           18    1935
NP_038472                                                              17    3301
NP_001175                                                              17    4312
XP_006711414                                                           16    5631
NP_001269461                                                           16    7355
NP_056154                                                              16    7355
NP_001269460                                                           16    7355
NP_689775                                                              16    7355
NP_852107                                                              16    7355
XP_006723822                                                           16    7355
XP_006716359                                                           16    7355
XP_006716358                                                           16    7355
XP_006716357                                                           16    7355
NP_061720                                                              16    7355
NP_001800                                                              15    9605
NP_001278261                                                           15    9605
NP_001034553                                                           15    9605
NP_001032590                                                           15    9605
NP_005465                                                              15    9605
NP_001015053                                                           15    9605
NP_001265522                                                           15    9605
NP_005580                                                              15    9605
NP_001157101                                                           15    9605
XP_005276345                                                           15    9605
XP_006721692                                                           15    9605
XP_005256964                                                           15    9605
XP_005256963                                                           15    9605
XP_005256962                                                           15    9605
XP_005256961                                                           15    9605
XP_005249985                                                           15    9605
XP_006710935                                                           15    9605
XP_003846678                                                           15    9605
>NP_004251
          Length = 1208

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QALLTL QG
Sbjct: 686 QALLTLLQG 694
>NP_038466
          Length = 589

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QALL +QQG
Sbjct: 461 QALLQIQQG 469
>NP_444295
          Length = 561

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QALL +QQG
Sbjct: 433 QALLQIQQG 441
>NP_064516
          Length = 601

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QALL +QQG
Sbjct: 467 QALLQIQQG 475
>XP_005245404
          Length = 565

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QALL +QQG
Sbjct: 467 QALLQIQQG 475
>NP_038472
          Length = 624

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QAL+ +QQG
Sbjct: 453 QALMQIQQG 461
>NP_001175
          Length = 2644

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QALLTLQQG 9
            QAL+ LQ+G
Sbjct: 1971 QALIVLQKG 1979
>XP_006711414
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  ALLTLQQG 9
          ALLT QQG
Sbjct: 6  ALLTHQQG 13
>NP_001269461
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 552 LTLQQG 557
>NP_056154
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 552 LTLQQG 557
>NP_001269460
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 552 LTLQQG 557
>NP_689775
          Length = 1023

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 731 LTLQQG 736
>NP_852107
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 552 LTLQQG 557
>XP_006723822
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 561 LTLQQG 566
>XP_006716359
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 736 LTLQQG 741
>XP_006716358
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 736 LTLQQG 741
>XP_006716357
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LTLQQG 9
           LTLQQG
Sbjct: 736 LTLQQG 741
>NP_061720
          Length = 4024

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QALLTLQQG 9
            Q +LT+Q+G
Sbjct: 1395 QQILTIQRG 1403
>NP_001800
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QALLTLQQ 8
          QALL LQ+
Sbjct: 89 QALLALQE 96
>NP_001278261
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LLTLQQG 9
           LLT+Q+G
Sbjct: 653 LLTMQEG 659
>NP_001034553
          Length = 1323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LLTLQQG 9
            LLT+Q+G
Sbjct: 1135 LLTMQEG 1141
>NP_001032590
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QALLTLQQ 8
           QALLTL +
Sbjct: 128 QALLTLDE 135
>NP_005465
          Length = 1122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QAL +L+QG
Sbjct: 402 QALQSLRQG 410
>NP_001015053
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QAL +L+QG
Sbjct: 403 QALQSLRQG 411
>NP_001265522
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LLTLQQG 9
           L+TL+QG
Sbjct: 109 LITLEQG 115
>NP_005580
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LLTLQQG 9
           L+TL+QG
Sbjct: 122 LITLEQG 128
>NP_001157101
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QALLTLQQ 8
           QALLTL++
Sbjct: 603 QALLTLRR 610
>XP_005276345
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QALLTLQQG 9
           +ALLT Q G
Sbjct: 128 EALLTSQMG 136
>XP_006721692
          Length = 1081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QAL +L+QG
Sbjct: 361 QALQSLRQG 369
>XP_005256964
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QAL +L+QG
Sbjct: 398 QALQSLRQG 406
>XP_005256963
          Length = 1122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QAL +L+QG
Sbjct: 402 QALQSLRQG 410
>XP_005256962
          Length = 1122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QAL +L+QG
Sbjct: 402 QALQSLRQG 410
>XP_005256961
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QALLTLQQG 9
           QAL +L+QG
Sbjct: 403 QALQSLRQG 411
>XP_005249985
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QALLTLQQG 9
           +ALLT Q G
Sbjct: 128 EALLTSQMG 136
>XP_006710935
          Length = 1280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QALLTLQQ 8
           QALLTL +
Sbjct: 195 QALLTLDE 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QALLTLQQ 8
           QALLTL +
Sbjct: 466 QALLTLDE 473
>XP_003846678
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QALLTLQQG 9
           +ALLT Q G
Sbjct: 95  EALLTSQMG 103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QALLTLQQG 9
           +ALLT Q G
Sbjct: 212 EALLTSQMG 220
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.130    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,942
Number of extensions: 659
Number of successful extensions: 38
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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