Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           18    1482
NP_858045                                                              18    1482
NP_006525                                                              18    1482
NP_001167559                                                           18    1482
NP_612485                                                              16    5631
NP_001186752                                                           16    5631
NP_597713                                                              16    7355
NP_001166171                                                           16    7355
NP_001164277                                                           16    7355
NP_075559                                                              16    7355
NP_775820                                                              16    7355
NP_065961                                                              16    7355
NP_001158137                                                           16    7355
NP_001073877                                                           16    7355
NP_001229936                                                           16    7355
XP_005267600                                                           16    7355
XP_006716134                                                           16    7355
XP_006714597                                                           16    7355
XP_005271944                                                           16    7355
XP_005271943                                                           16    7355
XP_006714596                                                           16    7355
XP_005271942                                                           16    7355
XP_005245269                                                           16    7355
XP_006711403                                                           16    7355
NP_006502                                                              16    7355
NP_653300                                                              16    7355
NP_444256                                                              15    9605
NP_444254                                                              15    9605
NP_444253                                                              15    9605
NP_444255                                                              15    9605
NP_001129496                                                           15    9605
NP_938011                                                              15    9605
NP_001019554                                                           15    9605
NP_055718                                                              15    9605
NP_775899                                                              15    9605
XP_005274596                                                           15    9605
XP_006724409                                                           15    9605
XP_005261851                                                           15    9605
XP_005261850                                                           15    9605
XP_006719739                                                           15    9605
XP_006719738                                                           15    9605
XP_005269272                                                           15    9605
XP_006718856                                                           15    9605
XP_006718855                                                           15    9605
XP_006718854                                                           15    9605
XP_006718853                                                           15    9605
XP_005271510                                                           15    9605
XP_005271509                                                           15    9605
XP_006718852                                                           15    9605
XP_006718851                                                           15    9605
XP_006714228                                                           15    9605
XP_006714227                                                           15    9605
XP_006714226                                                           15    9605
XP_006714225                                                           15    9605
XP_006714224                                                           15    9605
XP_006714223                                                           15    9605
XP_006714222                                                           15    9605
XP_006714221                                                           15    9605
XP_006714220                                                           15    9605
XP_005247551                                                           15    9605
XP_005247550                                                           15    9605
XP_006713712                                                           15    9605
XP_005247549                                                           15    9605
NP_001123539                                                           15    9605
NP_056086                                                              15    9605
NP_055044                                                              15    9605
NP_001138678                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QAISEGVET 9
           QAISEGV T
Sbjct: 527 QAISEGVGT 535
>NP_858045
          Length = 1424

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QAISEGVET 9
           QAISEGV T
Sbjct: 527 QAISEGVGT 535
>NP_006525
          Length = 1420

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QAISEGVET 9
           QAISEGV T
Sbjct: 527 QAISEGVGT 535
>NP_001167559
          Length = 1415

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QAISEGVET 9
           QAISEGV T
Sbjct: 537 QAISEGVGT 545
>NP_612485
          Length = 176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QAISEGVET 9
           Q +S+G+ET
Sbjct: 148 QTLSQGLET 156
>NP_001186752
          Length = 193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QAISEGVET 9
           Q +S+G+ET
Sbjct: 165 QTLSQGLET 173
>NP_597713
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA+ +G ET
Sbjct: 326 QAVPQGAET 334
>NP_001166171
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA+ +G ET
Sbjct: 326 QAVPQGAET 334
>NP_001164277
          Length = 56

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QAISEGVET 9
          + +SEG ET
Sbjct: 33 EKVSEGAET 41
>NP_075559
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AISEGVET 9
           ++SEG+ET
Sbjct: 146 SLSEGLET 153
>NP_775820
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           + +SEG ET
Sbjct: 351 EKVSEGAET 359
>NP_065961
          Length = 1934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AISEGVET 9
           +++EGVET
Sbjct: 272 SLTEGVET 279
>NP_001158137
          Length = 1950

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AISEGVET 9
           +++EGVET
Sbjct: 272 SLTEGVET 279
>NP_001073877
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QAISEGV 7
           QAIS+GV
Sbjct: 274 QAISDGV 280
>NP_001229936
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QAISEGV 7
           QAIS+GV
Sbjct: 501 QAISDGV 507
>XP_005267600
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QAISEGV 7
           QAIS+GV
Sbjct: 501 QAISDGV 507
>XP_006716134
          Length = 1847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AISEGVET 9
           +++EGVET
Sbjct: 196 SLTEGVET 203
>XP_006714597
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA+ +G ET
Sbjct: 326 QAVPQGAET 334
>XP_005271944
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA+ +G ET
Sbjct: 326 QAVPQGAET 334
>XP_005271943
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA+ +G ET
Sbjct: 326 QAVPQGAET 334
>XP_006714596
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA+ +G ET
Sbjct: 326 QAVPQGAET 334
>XP_005271942
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA+ +G ET
Sbjct: 326 QAVPQGAET 334
>XP_005245269
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISEGVET 9
           ISEG ET
Sbjct: 143 ISEGTET 149
>XP_006711403
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISEGVET 9
           ISEG ET
Sbjct: 572 ISEGTET 578
>NP_006502
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QAIS  VET
Sbjct: 418 QAISVSVET 426
>NP_653300
          Length = 1029

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISEGVET 9
           ISEG ET
Sbjct: 640 ISEGTET 646
>NP_444256
          Length = 1794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISEGVE 8
            ISEGVE
Sbjct: 1500 ISEGVE 1505
>NP_444254
          Length = 1845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISEGVE 8
            ISEGVE
Sbjct: 1500 ISEGVE 1505
>NP_444253
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISEGVE 8
            ISEGVE
Sbjct: 1569 ISEGVE 1574
>NP_444255
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISEGVE 8
            ISEGVE
Sbjct: 1569 ISEGVE 1574
>NP_001129496
          Length = 1474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAISEG 6
            QAISEG
Sbjct: 1450 QAISEG 1455
>NP_938011
          Length = 1630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAISEG 6
            QAISEG
Sbjct: 1606 QAISEG 1611
>NP_001019554
          Length = 2385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ISEGVET 9
           +SEGV+T
Sbjct: 370 VSEGVKT 376
>NP_055718
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ISEGVET 9
           +SEGV+T
Sbjct: 370 VSEGVKT 376
>NP_775899
          Length = 4462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAISEG 6
            QAISEG
Sbjct: 3476 QAISEG 3481
>XP_005274596
          Length = 1651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAISEG 6
            QAISEG
Sbjct: 1627 QAISEG 1632
>XP_006724409
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAISEGVE 8
           +A+SEG E
Sbjct: 158 KAVSEGAE 165
>XP_005261851
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAISEGVE 8
           +A+SEG E
Sbjct: 158 KAVSEGAE 165
>XP_005261850
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAISEGVE 8
           +A+SEG E
Sbjct: 158 KAVSEGAE 165
>XP_006719739
          Length = 2306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ISEGVET 9
           +SEGV+T
Sbjct: 313 VSEGVKT 319
>XP_006719738
          Length = 2340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ISEGVET 9
           +SEGV+T
Sbjct: 347 VSEGVKT 353
>XP_005269272
          Length = 2356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ISEGVET 9
           +SEGV+T
Sbjct: 370 VSEGVKT 376
>XP_006718856
          Length = 1976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAISEG 6
           QAISEG
Sbjct: 167 QAISEG 172
>XP_006718855
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAISEG 6
           QAISEG
Sbjct: 121 QAISEG 126
>XP_006718854
          Length = 1999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAISEG 6
           QAISEG
Sbjct: 167 QAISEG 172
>XP_006718853
          Length = 2017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAISEG 6
           QAISEG
Sbjct: 167 QAISEG 172
>XP_005271510
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAISEG 6
           QAISEG
Sbjct: 167 QAISEG 172
>XP_005271509
          Length = 2024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAISEG 6
           QAISEG
Sbjct: 167 QAISEG 172
>XP_006718852
          Length = 2025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAISEG 6
           QAISEG
Sbjct: 167 QAISEG 172
>XP_006718851
          Length = 2025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAISEG 6
           QAISEG
Sbjct: 167 QAISEG 172
>XP_006714228
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 135 QALNHGTET 143
>XP_006714227
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 135 QALNHGTET 143
>XP_006714226
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 141 QALNHGTET 149
>XP_006714225
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 260 QALNHGTET 268
>XP_006714224
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 260 QALNHGTET 268
>XP_006714223
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 260 QALNHGTET 268
>XP_006714222
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 278 QALNHGTET 286
>XP_006714221
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 286 QALNHGTET 294
>XP_006714220
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 287 QALNHGTET 295
>XP_005247551
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISEGVE 8
            ISEGVE
Sbjct: 1510 ISEGVE 1515
>XP_005247550
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISEGVE 8
            ISEGVE
Sbjct: 1511 ISEGVE 1516
>XP_006713712
          Length = 1923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISEGVE 8
            ISEGVE
Sbjct: 1579 ISEGVE 1584
>XP_005247549
          Length = 1924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISEGVE 8
            ISEGVE
Sbjct: 1579 ISEGVE 1584
>NP_001123539
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 260 QALNHGTET 268
>NP_056086
          Length = 771

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QAISEGVET 9
           QA++ G ET
Sbjct: 287 QALNHGTET 295
>NP_055044
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AISEGVE 8
           AIS+G+E
Sbjct: 213 AISDGIE 219
>NP_001138678
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAISEGVE 8
           +A+SEG E
Sbjct: 158 KAVSEGAE 165
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.114    0.265 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 499,642
Number of extensions: 877
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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