Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              19     869
NP_001091680                                                           19     869
NP_001091679                                                           19     869
XP_006713048                                                           19     869
XP_005264943                                                           19     869
NP_660288                                                              17    2528
NP_005656                                                              17    2528
NP_001153416                                                           17    2528
XP_005272515                                                           17    2528
XP_006710953                                                           17    2528
XP_005271239                                                           17    2528
XP_006710952                                                           17    2528
XP_006710951                                                           17    2528
XP_006710950                                                           17    2528
XP_006710949                                                           17    2528
XP_006710948                                                           17    2528
XP_006710947                                                           17    2528
XP_005271237                                                           17    2528
XP_005271236                                                           17    2528
NP_510880                                                              17    4312
NP_976063                                                              17    4312
NP_001103132                                                           16    5631
NP_001264352                                                           16    7355
XP_006724786                                                           16    7355
XP_006710322                                                           16    7355
NP_001104026                                                           15    9605
NP_001447                                                              15    9605
NP_742093                                                              15    9605
NP_001269238                                                           15    9605
NP_001274103                                                           15    9605
NP_000343                                                              15    9605
NP_001269239                                                           15    9605
NP_473361                                                              15    9605
NP_695000                                                              15    9605
NP_079375                                                              15    9605
NP_113584                                                              15    9605
NP_001172035                                                           15    9605
XP_005262029                                                           15    9605
XP_005262028                                                           15    9605
XP_005262026                                                           15    9605
XP_006724637                                                           15    9605
XP_005262025                                                           15    9605
XP_005262024                                                           15    9605
XP_005262023                                                           15    9605
XP_005262022                                                           15    9605
XP_006721642                                                           15    9605
XP_006721641                                                           15    9605
XP_006718349                                                           15    9605
>NP_001895
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QAGLMELDM 9
          QA LMELDM
Sbjct: 4  QADLMELDM 12
>NP_001091680
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QAGLMELDM 9
          QA LMELDM
Sbjct: 4  QADLMELDM 12
>NP_001091679
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QAGLMELDM 9
          QA LMELDM
Sbjct: 4  QADLMELDM 12
>XP_006713048
          Length = 720

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QAGLMELDM 9
          QA LMELDM
Sbjct: 4  QADLMELDM 12
>XP_005264943
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QAGLMELDM 9
          QA LMELDM
Sbjct: 4  QADLMELDM 12
>NP_660288
          Length = 794

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 316 QAELMQLDM 324
>NP_005656
          Length = 810

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 364 QAELMQLDM 372
>NP_001153416
          Length = 805

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 316 QAELMQLDM 324
>XP_005272515
          Length = 805

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 316 QAELMQLDM 324
>XP_006710953
          Length = 689

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 183 QAELMQLDM 191
>XP_005271239
          Length = 781

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 275 QAELMQLDM 283
>XP_006710952
          Length = 782

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 361 QAELMQLDM 369
>XP_006710951
          Length = 783

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 361 QAELMQLDM 369
>XP_006710950
          Length = 807

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 361 QAELMQLDM 369
>XP_006710949
          Length = 814

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 361 QAELMQLDM 369
>XP_006710948
          Length = 818

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 361 QAELMQLDM 369
>XP_006710947
          Length = 818

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 361 QAELMQLDM 369
>XP_005271237
          Length = 826

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 320 QAELMQLDM 328
>XP_005271236
          Length = 867

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QAGLMELDM 9
           QA LM+LDM
Sbjct: 361 QAELMQLDM 369
>NP_510880
          Length = 2054

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QAGLMELDM 9
            +AGL++LD+
Sbjct: 1081 EAGLLQLDV 1089
>NP_976063
          Length = 2039

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QAGLMELDM 9
            +AGL++LD+
Sbjct: 1081 EAGLLQLDV 1089
>NP_001103132
          Length = 4284

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    QAGLMELD 8
            Q GLME D
Sbjct: 4171 QVGLMETD 4178
>NP_001264352
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GLMELDM 9
           GLM++DM
Sbjct: 103 GLMKMDM 109
>XP_006724786
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GLMELDM 9
           GLM++DM
Sbjct: 198 GLMKMDM 204
>XP_006710322
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GLMELDM 9
           GLM++DM
Sbjct: 267 GLMKMDM 273
>NP_001104026
          Length = 2647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QAGLMELDM 9
            +AGL E+D+
Sbjct: 1836 EAGLHEMDI 1844
>NP_001447
          Length = 2639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QAGLMELDM 9
            +AGL E+D+
Sbjct: 1828 EAGLHEMDI 1836
>NP_742093
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GLMELD 8
           GLME+D
Sbjct: 480 GLMEMD 485
>NP_001269238
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GLMELD 8
           GLME+D
Sbjct: 478 GLMEMD 483
>NP_001274103
          Length = 1582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QAGLMEL 7
           QAG++EL
Sbjct: 870 QAGILEL 876
>NP_000343
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QAGLMEL 7
           QAG++EL
Sbjct: 869 QAGILEL 875
>NP_001269239
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GLMELD 8
           GLME+D
Sbjct: 484 GLMEMD 489
>NP_473361
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GLMELD 8
           GLME+D
Sbjct: 478 GLMEMD 483
>NP_695000
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GLMELD 8
           GLME+D
Sbjct: 142 GLMEID 147
>NP_079375
          Length = 1217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AGLMELD 8
           AGL ELD
Sbjct: 370 AGLYELD 376
>NP_113584
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>NP_001172035
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GLMELD 8
           GLME+D
Sbjct: 142 GLMEID 147
>XP_005262029
          Length = 4240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>XP_005262028
          Length = 4341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>XP_005262026
          Length = 4359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>XP_006724637
          Length = 4365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>XP_005262025
          Length = 4373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>XP_005262024
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>XP_005262023
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>XP_005262022
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QAGLMELD 8
           Q GL++LD
Sbjct: 842 QEGLLQLD 849
>XP_006721642
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AGLMELD 8
           AGL ELD
Sbjct: 370 AGLYELD 376
>XP_006721641
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AGLMELD 8
           AGL ELD
Sbjct: 370 AGLYELD 376
>XP_006718349
          Length = 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QAGLMEL 7
           QAG++EL
Sbjct: 869 QAGILEL 875
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.135    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 500,055
Number of extensions: 862
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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