Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              19     869
NP_001091680                                                           19     869
NP_001091679                                                           19     869
XP_006713048                                                           19     869
XP_005264943                                                           19     869
NP_001230115                                                           17    4312
NP_000375                                                              16    5631
NP_660288                                                              16    5631
NP_005656                                                              16    5631
NP_001153416                                                           16    5631
XP_005272515                                                           16    5631
XP_005270302                                                           16    5631
XP_006710953                                                           16    5631
XP_005271239                                                           16    5631
XP_006710952                                                           16    5631
XP_006710951                                                           16    5631
XP_006710950                                                           16    5631
XP_006710949                                                           16    5631
XP_006710948                                                           16    5631
XP_006710947                                                           16    5631
XP_005271237                                                           16    5631
XP_005271236                                                           16    5631
NP_002788                                                              16    7355
NP_001138404                                                           16    7355
NP_955452                                                              16    7355
XP_005267928                                                           16    7355
XP_006713543                                                           16    7355
NP_619639                                                              15    9605
NP_733842                                                              15    9605
NP_078920                                                              15    9605
>NP_001895
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QADLMELGM 9
          QADLMEL M
Sbjct: 4  QADLMELDM 12
>NP_001091680
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QADLMELGM 9
          QADLMEL M
Sbjct: 4  QADLMELDM 12
>NP_001091679
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QADLMELGM 9
          QADLMEL M
Sbjct: 4  QADLMELDM 12
>XP_006713048
          Length = 720

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QADLMELGM 9
          QADLMEL M
Sbjct: 4  QADLMELDM 12
>XP_005264943
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QADLMELGM 9
          QADLMEL M
Sbjct: 4  QADLMELDM 12
>NP_001230115
          Length = 404

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ADLMELGM 9
          AD++E+GM
Sbjct: 85 ADILEVGM 92
>NP_000375
          Length = 4563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ADLMELGM 9
           ADL+E+G+
Sbjct: 685 ADLIEIGL 692
>NP_660288
          Length = 794

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 316 QAELMQLDM 324
>NP_005656
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 364 QAELMQLDM 372
>NP_001153416
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 316 QAELMQLDM 324
>XP_005272515
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 316 QAELMQLDM 324
>XP_005270302
          Length = 105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ADLMELGM 9
          AD+M+LG+
Sbjct: 8  ADMMDLGI 15
>XP_006710953
          Length = 689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 183 QAELMQLDM 191
>XP_005271239
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 275 QAELMQLDM 283
>XP_006710952
          Length = 782

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 361 QAELMQLDM 369
>XP_006710951
          Length = 783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 361 QAELMQLDM 369
>XP_006710950
          Length = 807

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 361 QAELMQLDM 369
>XP_006710949
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 361 QAELMQLDM 369
>XP_006710948
          Length = 818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 361 QAELMQLDM 369
>XP_006710947
          Length = 818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 361 QAELMQLDM 369
>XP_005271237
          Length = 826

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 320 QAELMQLDM 328
>XP_005271236
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           QA+LM+L M
Sbjct: 361 QAELMQLDM 369
>NP_002788
          Length = 263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  QADLMELG 8
          +ADL++LG
Sbjct: 24 RADLLDLG 31
>NP_001138404
          Length = 203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  QADLMELG 8
          +ADL++LG
Sbjct: 24 RADLLDLG 31
>NP_955452
          Length = 2590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           Q DL+E+G+
Sbjct: 888 QQDLVEMGV 896
>XP_005267928
          Length = 169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  QADLMELG 8
          +ADL++LG
Sbjct: 24 RADLLDLG 31
>XP_006713543
          Length = 2591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELGM 9
           Q DL+E+G+
Sbjct: 889 QQDLVEMGV 897
>NP_619639
          Length = 4074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QADLMELGM 9
           Q DL+ +GM
Sbjct: 984 QTDLLPVGM 992
>NP_733842
          Length = 3396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QADLMELGM 9
           Q DL+ +GM
Sbjct: 984 QTDLLPVGM 992
>NP_078920
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   QADLMEL 7
           QAD MEL
Sbjct: 591 QADAMEL 597
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.135    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 445,836
Number of extensions: 963
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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