Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              18    1482
NP_001091680                                                           18    1482
NP_001091679                                                           18    1482
XP_006713048                                                           18    1482
XP_005264943                                                           18    1482
NP_851422                                                              17    3301
NP_001018861                                                           17    3301
XP_006720593                                                           17    3301
XP_005254446                                                           17    3301
NP_619729                                                              16    5631
NP_619730                                                              16    5631
NP_002436                                                              16    5631
NP_056980                                                              16    5631
NP_002171                                                              16    5631
NP_001243668                                                           16    5631
NP_001243667                                                           16    5631
NP_001243666                                                           16    5631
NP_005550                                                              16    5631
NP_076939                                                              16    5631
XP_005274034                                                           16    5631
XP_005274033                                                           16    5631
XP_005265273                                                           16    5631
NP_001035203                                                           16    7355
NP_074035                                                              16    7355
NP_001035202                                                           16    7355
NP_002465                                                              16    7355
NP_001269475                                                           16    7355
NP_001269476                                                           16    7355
NP_114406                                                              16    7355
NP_001028774                                                           16    7355
NP_003939                                                              16    7355
XP_006714469                                                           16    7355
XP_005263392                                                           16    7355
NP_056048                                                              16    7355
NP_062824                                                              15    9605
NP_001107562                                                           15    9605
NP_005898                                                              15    9605
NP_660288                                                              15    9605
NP_663747                                                              15    9605
NP_005656                                                              15    9605
NP_005506                                                              15    9605
NP_078920                                                              15    9605
NP_001153416                                                           15    9605
XP_005272515                                                           15    9605
XP_006716738                                                           15    9605
XP_006716737                                                           15    9605
XP_005272407                                                           15    9605
XP_006716020                                                           15    9605
XP_005267043                                                           15    9605
XP_006710953                                                           15    9605
XP_005271239                                                           15    9605
XP_006710952                                                           15    9605
XP_006710951                                                           15    9605
XP_006710950                                                           15    9605
XP_006710949                                                           15    9605
XP_006710948                                                           15    9605
XP_006710947                                                           15    9605
XP_005271237                                                           15    9605
XP_005271236                                                           15    9605
NP_001158727                                                           15    9605
NP_060425                                                              15    9605
NP_116291                                                              15    9605
>NP_001895
          Length = 781

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  QADLMELE 8
          QADLMEL+
Sbjct: 4  QADLMELD 11
>NP_001091680
          Length = 781

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  QADLMELE 8
          QADLMEL+
Sbjct: 4  QADLMELD 11
>NP_001091679
          Length = 781

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  QADLMELE 8
          QADLMEL+
Sbjct: 4  QADLMELD 11
>XP_006713048
          Length = 720

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  QADLMELE 8
          QADLMEL+
Sbjct: 4  QADLMELD 11
>XP_005264943
          Length = 781

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  QADLMELE 8
          QADLMEL+
Sbjct: 4  QADLMELD 11
>NP_851422
          Length = 603

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           Q+DL EL+H
Sbjct: 363 QSDLEELKH 371
>NP_001018861
          Length = 603

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           Q+DL EL+H
Sbjct: 363 QSDLEELKH 371
>XP_006720593
          Length = 603

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           Q+DL EL+H
Sbjct: 363 QSDLEELKH 371
>XP_005254446
          Length = 603

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           Q+DL EL+H
Sbjct: 363 QSDLEELKH 371
>NP_619729
          Length = 451

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           +A+LM+ EH
Sbjct: 132 EANLMDTEH 140
>NP_619730
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           +A+LM+ EH
Sbjct: 132 EANLMDTEH 140
>NP_002436
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           +A+LM+ EH
Sbjct: 132 EANLMDTEH 140
>NP_056980
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QADLMELE 8
           QA+LME E
Sbjct: 175 QAELMEFE 182
>NP_002171
          Length = 993

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QADLMELE 8
          Q DL+ELE
Sbjct: 13 QLDLLELE 20
>NP_001243668
          Length = 309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DLMELEH 9
           DLM+L+H
Sbjct: 133 DLMKLDH 139
>NP_001243667
          Length = 278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DLMELEH 9
           DLM+L+H
Sbjct: 102 DLMKLDH 108
>NP_001243666
          Length = 386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DLMELEH 9
           DLM+L+H
Sbjct: 210 DLMKLDH 216
>NP_005550
          Length = 3075

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ADLMELEH 9
           ADLM L H
Sbjct: 236 ADLMTLSH 243
>NP_076939
          Length = 367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DLMELEH 9
           DLM+L+H
Sbjct: 191 DLMKLDH 197
>XP_005274034
          Length = 508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QADLMELE 8
          Q DL+ELE
Sbjct: 13 QLDLLELE 20
>XP_005274033
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QADLMELE 8
          Q DL+ELE
Sbjct: 13 QLDLLELE 20
>XP_005265273
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QADLMELE 8
           QA+LME E
Sbjct: 96  QAELMEFE 103
>NP_001035203
          Length = 1979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QADLMELE 8
            +ADLM+L+
Sbjct: 1693 EADLMQLQ 1700
>NP_074035
          Length = 1938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QADLMELE 8
            +ADLM+L+
Sbjct: 1686 EADLMQLQ 1693
>NP_001035202
          Length = 1945

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QADLMELE 8
            +ADLM+L+
Sbjct: 1693 EADLMQLQ 1700
>NP_002465
          Length = 1972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QADLMELE 8
            +ADLM+L+
Sbjct: 1686 EADLMQLQ 1693
>NP_001269475
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADLMELEH 9
           ADL+ L+H
Sbjct: 159 ADLINLQH 166
>NP_001269476
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADLMELEH 9
           ADL+ L+H
Sbjct: 154 ADLINLQH 161
>NP_114406
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADLMELEH 9
           ADL+ L+H
Sbjct: 154 ADLINLQH 161
>NP_001028774
          Length = 1379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QADLMELE 8
            QA+L ELE
Sbjct: 1104 QAELQELE 1111
>NP_003939
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADLMELEH 9
           ADL ++EH
Sbjct: 484 ADLPQMEH 491
>XP_006714469
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADLMELEH 9
           ADL ++EH
Sbjct: 521 ADLPQMEH 528
>XP_005263392
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADLMELEH 9
           ADL ++EH
Sbjct: 561 ADLPQMEH 568
>NP_056048
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QADLMELE 8
          QA+L ELE
Sbjct: 73 QAELQELE 80
>NP_062824
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LMELEH 9
           L+ELEH
Sbjct: 332 LLELEH 337
>NP_001107562
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LMELEH 9
           L+ELEH
Sbjct: 240 LLELEH 245
>NP_005898
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DLMELEH 9
           DL+ LEH
Sbjct: 622 DLLPLEH 628
>NP_660288
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 316 QAELMQLD 323
>NP_663747
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           ++DL EL+H
Sbjct: 225 KSDLGELDH 233
>NP_005656
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 364 QAELMQLD 371
>NP_005506
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LMELEH 9
           L+ELEH
Sbjct: 253 LLELEH 258
>NP_078920
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   QADLMEL 7
           QAD MEL
Sbjct: 591 QADAMEL 597
>NP_001153416
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 316 QAELMQLD 323
>XP_005272515
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 316 QAELMQLD 323
>XP_006716738
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           +A L+EL+H
Sbjct: 311 RAKLLELKH 319
>XP_006716737
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           +A L+EL+H
Sbjct: 311 RAKLLELKH 319
>XP_005272407
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           +A L+EL+H
Sbjct: 311 RAKLLELKH 319
>XP_006716020
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LMELEH 9
           L+ELEH
Sbjct: 218 LLELEH 223
>XP_005267043
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DLMELEH 9
           DL+ LEH
Sbjct: 705 DLLPLEH 711
>XP_006710953
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 183 QAELMQLD 190
>XP_005271239
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 275 QAELMQLD 282
>XP_006710952
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710951
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710950
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710949
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710948
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710947
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_005271237
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 320 QAELMQLD 327
>XP_005271236
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QADLMELE 8
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>NP_001158727
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMELEH 9
          L+ELEH
Sbjct: 41 LLELEH 46
>NP_060425
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           ++DL EL+H
Sbjct: 225 KSDLGELDH 233
>NP_116291
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QADLMELEH 9
           +A L+EL+H
Sbjct: 311 RAKLLELKH 319
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.128    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 593,420
Number of extensions: 1653
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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