Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              19     869
XP_005273257                                                           19     869
NP_878918                                                              17    3301
NP_055995                                                              17    3301
XP_006720147                                                           17    3301
XP_005267517                                                           17    3301
XP_005267516                                                           17    3301
XP_005267515                                                           17    3301
XP_005267514                                                           17    3301
XP_005267513                                                           17    3301
XP_005267512                                                           17    3301
XP_005267511                                                           17    3301
NP_008949                                                              15    9605
NP_079467                                                              15    9605
XP_006717006                                                           15    9605
XP_006717005                                                           15    9605
XP_006717004                                                           15    9605
XP_006717003                                                           15    9605
XP_005251736                                                           15    9605
XP_005245556                                                           15    9605
>NP_064450
          Length = 1722

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q AEENSLT
Sbjct: 1624 QEAEENSLT 1632
>XP_005273257
          Length = 1726

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q AEENSLT
Sbjct: 1628 QEAEENSLT 1636
>NP_878918
          Length = 6907

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>NP_055995
          Length = 6885

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>XP_006720147
          Length = 4788

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>XP_005267517
          Length = 6883

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>XP_005267516
          Length = 6884

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>XP_005267515
          Length = 6899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>XP_005267514
          Length = 6908

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>XP_005267513
          Length = 6921

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>XP_005267512
          Length = 6922

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>XP_005267511
          Length = 6922

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QAAEENSLT 9
            Q A+EN+LT
Sbjct: 1351 QVAQENTLT 1359
>NP_008949
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    AAEENS 7
            AAEENS
Sbjct: 1812 AAEENS 1817
>NP_079467
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QAAEENSL 8
           +++EENSL
Sbjct: 833 ESSEENSL 840
>XP_006717006
          Length = 1760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    AAEENS 7
            AAEENS
Sbjct: 1232 AAEENS 1237
>XP_006717005
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    AAEENS 7
            AAEENS
Sbjct: 1260 AAEENS 1265
>XP_006717004
          Length = 2240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    AAEENS 7
            AAEENS
Sbjct: 1812 AAEENS 1817
>XP_006717003
          Length = 2278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    AAEENS 7
            AAEENS
Sbjct: 1812 AAEENS 1817
>XP_005251736
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    AAEENS 7
            AAEENS
Sbjct: 1812 AAEENS 1817
>XP_005245556
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QAAEENSL 8
           +++EENSL
Sbjct: 834 ESSEENSL 841
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.279   0.0954    0.208 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 470,977
Number of extensions: 326
Number of successful extensions: 20
Number of sequences better than 10000.0: 20
Number of HSP's gapped: 20
Number of HSP's successfully gapped: 20
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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