Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              21     175
NP_444254                                                              21     175
NP_444253                                                              21     175
NP_444255                                                              21     175
NP_444260                                                              21     175
NP_444259                                                              21     175
XP_005247551                                                           21     175
XP_005247550                                                           21     175
XP_006713712                                                           21     175
XP_005247549                                                           21     175
NP_001188457                                                           17    4312
NP_001188458                                                           17    4312
NP_002585                                                              17    4312
NP_003873                                                              16    5631
NP_543028                                                              16    5631
NP_001191799                                                           16    5631
NP_006285                                                              16    5631
NP_001025054                                                           16    5631
NP_001186904                                                           16    5631
NP_060107                                                              16    5631
NP_055754                                                              16    5631
XP_005258292                                                           16    5631
XP_006722483                                                           16    5631
XP_005258291                                                           16    5631
XP_005258290                                                           16    5631
XP_006716851                                                           16    5631
XP_006716850                                                           16    5631
XP_006716849                                                           16    5631
XP_006716848                                                           16    5631
XP_006716847                                                           16    5631
XP_006716743                                                           16    5631
NP_001035805                                                           16    5631
NP_055826                                                              16    7355
NP_001185879                                                           16    7355
NP_037498                                                              16    7355
NP_057300                                                              16    7355
NP_060903                                                              16    7355
NP_001140160                                                           16    7355
NP_056173                                                              16    7355
NP_997304                                                              16    7355
XP_006724049                                                           16    7355
XP_006724048                                                           16    7355
NP_067648                                                              16    7355
NP_004906                                                              15    9605
NP_997511                                                              15    9605
NP_058198                                                              15    9605
NP_997512                                                              15    9605
NP_997510                                                              15    9605
NP_997057                                                              15    9605
NP_001136019                                                           15    9605
NP_775930                                                              15    9605
NP_075463                                                              15    9605
XP_006719812                                                           15    9605
XP_005248394                                                           15    9605
NP_001135977                                                           15    9605
NP_071452                                                              15    9605
NP_954993                                                              15    9605
>NP_444256
          Length = 1794

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PYLSKTIRD 9
            PY SKTIRD
Sbjct: 1689 PYFSKTIRD 1697
>NP_444254
          Length = 1845

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PYLSKTIRD 9
            PY SKTIRD
Sbjct: 1740 PYFSKTIRD 1748
>NP_444253
          Length = 1914

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PYLSKTIRD 9
            PY SKTIRD
Sbjct: 1809 PYFSKTIRD 1817
>NP_444255
          Length = 1863

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PYLSKTIRD 9
            PY SKTIRD
Sbjct: 1758 PYFSKTIRD 1766
>NP_444260
          Length = 154

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  PYLSKTIRD 9
          PY SKTIRD
Sbjct: 49 PYFSKTIRD 57
>NP_444259
          Length = 153

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  PYLSKTIRD 9
          PY SKTIRD
Sbjct: 48 PYFSKTIRD 56
>XP_005247551
          Length = 1855

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PYLSKTIRD 9
            PY SKTIRD
Sbjct: 1750 PYFSKTIRD 1758
>XP_005247550
          Length = 1856

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PYLSKTIRD 9
            PY SKTIRD
Sbjct: 1751 PYFSKTIRD 1759
>XP_006713712
          Length = 1923

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PYLSKTIRD 9
            PY SKTIRD
Sbjct: 1818 PYFSKTIRD 1826
>XP_005247549
          Length = 1924

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PYLSKTIRD 9
            PY SKTIRD
Sbjct: 1819 PYFSKTIRD 1827
>NP_001188457
          Length = 619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           PY+ + +RD
Sbjct: 579 PYIDQVVRD 587
>NP_001188458
          Length = 603

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           PY+ + +RD
Sbjct: 563 PYIDQVVRD 571
>NP_002585
          Length = 638

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           PY+ + +RD
Sbjct: 598 PYIDQVVRD 606
>NP_003873
          Length = 367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PYLSKTI 7
           PY SKTI
Sbjct: 312 PYKSKTI 318
>NP_543028
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PYLSKTI 7
           PY SKTI
Sbjct: 225 PYKSKTI 231
>NP_001191799
          Length = 122

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PYLSKTI 7
          PY SKTI
Sbjct: 67 PYKSKTI 73
>NP_006285
          Length = 111

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           PYL + IR+
Sbjct: 93  PYLKEVIRE 101
>NP_001025054
          Length = 1288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PYLSKTIR 8
           P+LSKT R
Sbjct: 467 PHLSKTSR 474
>NP_001186904
          Length = 79

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PYLSKTIRD 9
          PYL + IR+
Sbjct: 61 PYLKEVIRE 69
>NP_060107
          Length = 1099

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           P LSK +RD
Sbjct: 906 PSLSKDLRD 914
>NP_055754
          Length = 1435

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PYLSKTIR 8
           P++ KTIR
Sbjct: 362 PHIEKTIR 369
>XP_005258292
          Length = 1161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PYLSKTIR 8
          P++ KTIR
Sbjct: 88 PHIEKTIR 95
>XP_006722483
          Length = 1338

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PYLSKTIR 8
           P++ KTIR
Sbjct: 363 PHIEKTIR 370
>XP_005258291
          Length = 1406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PYLSKTIR 8
           P++ KTIR
Sbjct: 363 PHIEKTIR 370
>XP_005258290
          Length = 1436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PYLSKTIR 8
           P++ KTIR
Sbjct: 363 PHIEKTIR 370
>XP_006716851
          Length = 1008

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           P LSK +RD
Sbjct: 815 PSLSKDLRD 823
>XP_006716850
          Length = 1121

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           P LSK +RD
Sbjct: 928 PSLSKDLRD 936
>XP_006716849
          Length = 1125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           P LSK +RD
Sbjct: 932 PSLSKDLRD 940
>XP_006716848
          Length = 1127

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           P LSK +RD
Sbjct: 934 PSLSKDLRD 942
>XP_006716847
          Length = 1149

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYLSKTIRD 9
           P LSK +RD
Sbjct: 956 PSLSKDLRD 964
>XP_006716743
          Length = 202

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PYLSKTI 7
           PY SKTI
Sbjct: 147 PYKSKTI 153
>NP_001035805
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PYLSKTIRD 9
           P+++KT RD
Sbjct: 120 PHIAKTQRD 128
>NP_055826
          Length = 1858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YLSKTIRD 9
           YL++TI+D
Sbjct: 621 YLNQTIQD 628
>NP_001185879
          Length = 1880

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YLSKTIRD 9
           YL++TI+D
Sbjct: 643 YLNQTIQD 650
>NP_037498
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YLSKTIRD 9
           YL K +RD
Sbjct: 798 YLQKKVRD 805
>NP_057300
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYLSKTIR 8
           PY S TIR
Sbjct: 141 PYNSSTIR 148
>NP_060903
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PYLSKTIR 8
          P+LS TIR
Sbjct: 42 PWLSGTIR 49
>NP_001140160
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PYLSKTIR 8
          P+LS TIR
Sbjct: 42 PWLSGTIR 49
>NP_056173
          Length = 939

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YLSKTIR 8
           +LSKT+R
Sbjct: 294 FLSKTVR 300
>NP_997304
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LSKTIRD 9
           +SKT+RD
Sbjct: 452 MSKTLRD 458
>XP_006724049
          Length = 978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YLSKTIR 8
           +LSKT+R
Sbjct: 333 FLSKTVR 339
>XP_006724048
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YLSKTIR 8
           +LSKT+R
Sbjct: 223 FLSKTVR 229
>NP_067648
          Length = 135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YLSKTI 7
           YLSKTI
Sbjct: 125 YLSKTI 130
>NP_004906
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YL+KT+ D
Sbjct: 499 YLAKTMAD 506
>NP_997511
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YL+KT+ D
Sbjct: 465 YLAKTMAD 472
>NP_058198
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YL+KT+ D
Sbjct: 487 YLAKTMAD 494
>NP_997512
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YL+KT+ D
Sbjct: 484 YLAKTMAD 491
>NP_997510
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YL+KT+ D
Sbjct: 489 YLAKTMAD 496
>NP_997057
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YL+KT+ D
Sbjct: 498 YLAKTMAD 505
>NP_001136019
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PYLSKTIR 8
           PY S+T++
Sbjct: 322 PYFSRTLQ 329
>NP_775930
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PYLSKTIR 8
           PY S+T++
Sbjct: 337 PYFSRTLQ 344
>NP_075463
          Length = 3013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YLSKT+ +
Sbjct: 537 YLSKTLTE 544
>XP_006719812
          Length = 3019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YLSKT+ +
Sbjct: 534 YLSKTLTE 541
>XP_005248394
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PYLSKTIR 8
          P+LS+T R
Sbjct: 26 PFLSRTSR 33
>NP_001135977
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YL+KT+ D
Sbjct: 468 YLAKTMAD 475
>NP_071452
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YL+KT+ D
Sbjct: 468 YLAKTMAD 475
>NP_954993
          Length = 571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YLSKTIRD 9
           YLS+ +RD
Sbjct: 418 YLSQMLRD 425
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.138    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 417,695
Number of extensions: 643
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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