Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           21     229
NP_036462                                                              21     229
NP_001243397                                                           21     229
NP_859526                                                              21     229
NP_002543                                                              21     229
NP_001177810                                                           21     229
NP_001177808                                                           21     229
NP_001177811                                                           21     229
NP_859525                                                              21     229
XP_005269721                                                           21     229
XP_006712619                                                           21     229
NP_001017969                                                           18    1935
NP_060640                                                              18    1935
XP_005258351                                                           18    1935
XP_005258350                                                           18    1935
XP_006716793                                                           18    1935
XP_005251442                                                           18    1935
NP_114171                                                              17    3301
NP_000531                                                              17    4312
NP_001036188                                                           17    4312
NP_056355                                                              17    4312
XP_006723382                                                           17    4312
XP_006723381                                                           17    4312
XP_006723380                                                           17    4312
XP_006720533                                                           17    4312
XP_006720532                                                           17    4312
XP_005254354                                                           17    4312
NP_065996                                                              16    5631
XP_005270063                                                           16    5631
XP_005270062                                                           16    5631
XP_005270061                                                           16    5631
NP_001366                                                              16    5631
NP_008840                                                              16    7355
NP_001139                                                              16    7355
NP_001121685                                                           16    7355
NP_001121684                                                           16    7355
XP_005248621                                                           16    7355
XP_006714729                                                           16    7355
XP_006714728                                                           16    7355
XP_006714257                                                           16    7355
XP_005263002                                                           16    7355
XP_005262999                                                           16    7355
XP_006714252                                                           16    7355
XP_006714251                                                           16    7355
XP_006714250                                                           16    7355
XP_006712404                                                           16    7355
XP_005246412                                                           16    7355
XP_006710844                                                           16    7355
NP_689741                                                              16    7355
NP_000950                                                              16    7355
NP_001034674                                                           16    7355
NP_110438                                                              16    7355
NP_001005237                                                           16    7355
NP_001706                                                              15    9605
NP_004658                                                              15    9605
NP_061092                                                              15    9605
NP_001230925                                                           15    9605
NP_001027                                                              15    9605
NP_006827                                                              15    9605
NP_003661                                                              15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
XP_005272447                                                           15    9605
XP_006716315                                                           15    9605
XP_006716314                                                           15    9605
XP_006716313                                                           15    9605
XP_005247644                                                           15    9605
XP_005247643                                                           15    9605
XP_005247641                                                           15    9605
XP_005247640                                                           15    9605
XP_005247639                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PVLMKAFQH 9
           PVL KAFQH
Sbjct: 895 PVLRKAFQH 903
>NP_036462
          Length = 2073

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PVLMKAFQH 9
            PVL KAFQH
Sbjct: 1187 PVLRKAFQH 1195
>NP_001243397
          Length = 1890

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PVLMKAFQH 9
            PVL KAFQH
Sbjct: 1004 PVLRKAFQH 1012
>NP_859526
          Length = 436

 Score = 20.8 bits (42), Expect =   229
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PVLMKAFQH 9
           PV+MKAF+H
Sbjct: 370 PVVMKAFEH 378
>NP_002543
          Length = 436

 Score = 20.8 bits (42), Expect =   229
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PVLMKAFQH 9
           PV+MKAF+H
Sbjct: 370 PVVMKAFEH 378
>NP_001177810
          Length = 352

 Score = 20.8 bits (42), Expect =   229
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PVLMKAFQH 9
           PV+MKAF+H
Sbjct: 286 PVVMKAFEH 294
>NP_001177808
          Length = 436

 Score = 20.8 bits (42), Expect =   229
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PVLMKAFQH 9
           PV+MKAF+H
Sbjct: 370 PVVMKAFEH 378
>NP_001177811
          Length = 362

 Score = 20.8 bits (42), Expect =   229
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PVLMKAFQH 9
           PV+MKAF+H
Sbjct: 296 PVVMKAFEH 304
>NP_859525
          Length = 436

 Score = 20.8 bits (42), Expect =   229
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PVLMKAFQH 9
           PV+MKAF+H
Sbjct: 370 PVVMKAFEH 378
>XP_005269721
          Length = 2073

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PVLMKAFQH 9
            PVL KAFQH
Sbjct: 1187 PVLRKAFQH 1195
>XP_006712619
          Length = 352

 Score = 20.8 bits (42), Expect =   229
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PVLMKAFQH 9
           PV+MKAF+H
Sbjct: 286 PVVMKAFEH 294
>NP_001017969
          Length = 2103

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PVLMKAFQ 8
           P LMKAFQ
Sbjct: 823 PKLMKAFQ 830
>NP_060640
          Length = 312

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  PVLMKAFQH 9
          PV+++AF+H
Sbjct: 83 PVIVEAFKH 91
>XP_005258351
          Length = 276

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  PVLMKAFQH 9
          PV+++AF+H
Sbjct: 47 PVIVEAFKH 55
>XP_005258350
          Length = 289

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  PVLMKAFQH 9
          PV+++AF+H
Sbjct: 83 PVIVEAFKH 91
>XP_006716793
          Length = 1317

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  PVLMKAFQ 8
          P LMKAFQ
Sbjct: 37 PKLMKAFQ 44
>XP_005251442
          Length = 2073

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PVLMKAFQ 8
           P LMKAFQ
Sbjct: 793 PKLMKAFQ 800
>NP_114171
          Length = 798

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PVLMKAFQH 9
           P+L+KA+ H
Sbjct: 571 PLLLKAWDH 579
>NP_000531
          Length = 5038

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            PVL   FQH
Sbjct: 3138 PVLTTLFQH 3146
>NP_001036188
          Length = 5033

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            PVL   FQH
Sbjct: 3138 PVLTTLFQH 3146
>NP_056355
          Length = 1393

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVLMKAFQ 8
           PVLM+A Q
Sbjct: 696 PVLMRALQ 703
>XP_006723382
          Length = 5027

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            PVL   FQH
Sbjct: 3138 PVLTTLFQH 3146
>XP_006723381
          Length = 5031

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            PVL   FQH
Sbjct: 3137 PVLTTLFQH 3145
>XP_006723380
          Length = 5032

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            PVL   FQH
Sbjct: 3138 PVLTTLFQH 3146
>XP_006720533
          Length = 1098

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVLMKAFQ 8
           PVLM+A Q
Sbjct: 401 PVLMRALQ 408
>XP_006720532
          Length = 1333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVLMKAFQ 8
           PVLM+A Q
Sbjct: 636 PVLMRALQ 643
>XP_005254354
          Length = 1393

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVLMKAFQ 8
           PVLM+A Q
Sbjct: 696 PVLMRALQ 703
>NP_065996
          Length = 3184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  PVLMKAFQH 9
          P+ +KA++H
Sbjct: 74 PLFLKAWEH 82
>XP_005270063
          Length = 2005

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  PVLMKAFQH 9
          P+ +KA++H
Sbjct: 74 PLFLKAWEH 82
>XP_005270062
          Length = 3184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  PVLMKAFQH 9
          P+ +KA++H
Sbjct: 74 PLFLKAWEH 82
>XP_005270061
          Length = 3184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  PVLMKAFQH 9
          P+ +KA++H
Sbjct: 74 PLFLKAWEH 82
>NP_001366
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PVLMKAFQ 8
           P L KAFQ
Sbjct: 331 PALWKAFQ 338
>NP_008840
          Length = 1237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            P +MK  QH
Sbjct: 1041 PYIMKTSQH 1049
>NP_001139
          Length = 3957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LMKAFQ 8
            LMKAFQ
Sbjct: 1993 LMKAFQ 1998
>NP_001121685
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           PVL  AF H
Sbjct: 241 PVLACAFSH 249
>NP_001121684
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           PVL  AF H
Sbjct: 241 PVLACAFSH 249
>XP_005248621
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           P +MK  QH
Sbjct: 969 PYIMKTSQH 977
>XP_006714729
          Length = 1214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            P +MK  QH
Sbjct: 1041 PYIMKTSQH 1049
>XP_006714728
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            P +MK  QH
Sbjct: 1039 PYIMKTSQH 1047
>XP_006714257
          Length = 4145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LMKAFQ 8
            LMKAFQ
Sbjct: 2002 LMKAFQ 2007
>XP_005263002
          Length = 4072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LMKAFQ 8
            LMKAFQ
Sbjct: 1960 LMKAFQ 1965
>XP_005262999
          Length = 4147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LMKAFQ 8
            LMKAFQ
Sbjct: 2004 LMKAFQ 2009
>XP_006714252
          Length = 4153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LMKAFQ 8
            LMKAFQ
Sbjct: 2010 LMKAFQ 2015
>XP_006714251
          Length = 4165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LMKAFQ 8
            LMKAFQ
Sbjct: 2022 LMKAFQ 2027
>XP_006714250
          Length = 4190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LMKAFQ 8
            LMKAFQ
Sbjct: 2047 LMKAFQ 2052
>XP_006712404
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PVLMKAFQH 9
          PVL  AF H
Sbjct: 72 PVLACAFSH 80
>XP_005246412
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           PVL  AF H
Sbjct: 241 PVLACAFSH 249
>XP_006710844
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VLMKAFQ 8
          +LMKA+Q
Sbjct: 50 ILMKAYQ 56
>NP_689741
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           PVL  AF H
Sbjct: 241 PVLACAFSH 249
>NP_000950
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VLMKAFQ 8
          +LMKA+Q
Sbjct: 50 ILMKAYQ 56
>NP_001034674
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VLMKAFQ 8
          +LMKA+Q
Sbjct: 50 ILMKAYQ 56
>NP_110438
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VLMKAFQH 9
          VLM+ +QH
Sbjct: 55 VLMERYQH 62
>NP_001005237
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PVLMKAFQH 9
           P L+K FQ+
Sbjct: 162 PFLLKRFQY 170
>NP_001706
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LMKAFQH 9
           +MKA QH
Sbjct: 287 VMKALQH 293
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    PVLMKAFQH 9
            P L+++ QH
Sbjct: 4028 PTLLESIQH 4036
>NP_061092
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           P+L+  F H
Sbjct: 208 PMLLSTFSH 216
>NP_001230925
          Length = 4865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            P+L   F+H
Sbjct: 2999 PILTSIFEH 3007
>NP_001027
          Length = 4870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    PVLMKAFQH 9
            P+L   F+H
Sbjct: 2999 PILTSIFEH 3007
>NP_006827
          Length = 2671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    PVLMKAFQ 8
            P++ +AFQ
Sbjct: 1618 PIVQRAFQ 1625
>NP_003661
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           PV+ + F H
Sbjct: 221 PVIQRTFAH 229
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    PVLMKAFQH 9
            P L+++ QH
Sbjct: 3942 PTLLESIQH 3950
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    PVLMKAFQH 9
            P L+++ QH
Sbjct: 3990 PTLLESIQH 3998
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    PVLMKAFQH 9
            P L+++ QH
Sbjct: 3990 PTLLESIQH 3998
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    PVLMKAFQH 9
            P L+++ QH
Sbjct: 4023 PTLLESIQH 4031
>XP_005272447
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LMKAFQH 9
           +MKA QH
Sbjct: 216 VMKALQH 222
>XP_006716315
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LMKAFQH 9
           +MKA QH
Sbjct: 287 VMKALQH 293
>XP_006716314
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LMKAFQH 9
           +MKA QH
Sbjct: 287 VMKALQH 293
>XP_006716313
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LMKAFQH 9
           +MKA QH
Sbjct: 287 VMKALQH 293
>XP_005247644
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  PVLMKAFQH 9
          P+L+  F H
Sbjct: 17 PMLLSTFSH 25
>XP_005247643
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  PVLMKAFQH 9
          P+L+  F H
Sbjct: 17 PMLLSTFSH 25
>XP_005247641
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           P+L+  F H
Sbjct: 208 PMLLSTFSH 216
>XP_005247640
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           P+L+  F H
Sbjct: 208 PMLLSTFSH 216
>XP_005247639
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   PVLMKAFQH 9
           P+L+  F H
Sbjct: 208 PMLLSTFSH 216
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.139    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 458,191
Number of extensions: 989
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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