Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           18    1135
NP_000170                                                              18    1135
NP_001268422                                                           18    1135
NP_001268423                                                           18    1135
XP_005264328                                                           18    1135
NP_001129978                                                           17    2528
NP_001157101                                                           17    4312
NP_877963                                                              16    5631
NP_002651                                                              16    5631
NP_001073932                                                           16    5631
NP_001368                                                              16    5631
NP_001013649                                                           16    5631
XP_006724707                                                           16    5631
XP_005260495                                                           16    5631
XP_006718966                                                           16    5631
NP_001161210                                                           16    7355
NP_065176                                                              16    7355
NP_001032409                                                           16    7355
XP_006711674                                                           16    7355
XP_006711673                                                           16    7355
XP_006711672                                                           16    7355
XP_006711671                                                           16    7355
XP_006711670                                                           16    7355
XP_005245629                                                           16    7355
NP_056499                                                              16    7355
NP_001032410                                                           16    7355
NP_055191                                                              16    7355
NP_001182156                                                           15    9605
NP_060106                                                              15    9605
NP_060142                                                              15    9605
NP_940905                                                              15    9605
NP_001274748                                                           15    9605
NP_001274749                                                           15    9605
NP_115927                                                              15    9605
NP_001996                                                              15    9605
NP_001137257                                                           15    9605
NP_001269335                                                           15    9605
NP_065873                                                              15    9605
NP_001137255                                                           15    9605
NP_001258932                                                           15    9605
NP_001137256                                                           15    9605
NP_862820                                                              15    9605
NP_001184188                                                           15    9605
NP_036513                                                              15    9605
XP_006723312                                                           15    9605
XP_006720645                                                           15    9605
XP_005254546                                                           15    9605
XP_005254545                                                           15    9605
XP_005254544                                                           15    9605
XP_005254543                                                           15    9605
XP_005254939                                                           15    9605
XP_005254938                                                           15    9605
XP_005254937                                                           15    9605
XP_005254934                                                           15    9605
XP_006717257                                                           15    9605
XP_006717256                                                           15    9605
XP_005248763                                                           15    9605
XP_005248762                                                           15    9605
XP_005248761                                                           15    9605
XP_006711360                                                           15    9605
XP_006711359                                                           15    9605
XP_006711358                                                           15    9605
XP_006711357                                                           15    9605
NP_076419                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PVILLLEDT 9
           PVILL EDT
Sbjct: 947 PVILLPEDT 955
>NP_000170
          Length = 1360

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PVILLLEDT 9
            PVILL EDT
Sbjct: 1077 PVILLPEDT 1085
>NP_001268422
          Length = 1058

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PVILLLEDT 9
           PVILL EDT
Sbjct: 775 PVILLPEDT 783
>NP_001268423
          Length = 1058

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PVILLLEDT 9
           PVILL EDT
Sbjct: 775 PVILLPEDT 783
>XP_005264328
          Length = 1261

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PVILLLEDT 9
           PVILL EDT
Sbjct: 978 PVILLPEDT 986
>NP_001129978
          Length = 552

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PVILLLEDT 9
           PVILLL +T
Sbjct: 510 PVILLLPET 518
>NP_001157101
          Length = 861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P+IL LED
Sbjct: 673 PLILFLED 680
>NP_877963
          Length = 1290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           PVIL +ED
Sbjct: 408 PVILSIED 415
>NP_002651
          Length = 1291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           PVIL +ED
Sbjct: 408 PVILSIED 415
>NP_001073932
          Length = 4314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VILLLED 8
            V+LLLED
Sbjct: 2708 VVLLLED 2714
>NP_001368
          Length = 4307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VILLLED 8
            V+LLLED
Sbjct: 2708 VVLLLED 2714
>NP_001013649
          Length = 1225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PVILLLEDT 9
            P+I L EDT
Sbjct: 1035 PIITLEEDT 1043
>XP_006724707
          Length = 1337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PVILLLEDT 9
            P+I L EDT
Sbjct: 1147 PIITLEEDT 1155
>XP_005260495
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           PVIL +ED
Sbjct: 408 PVILSIED 415
>XP_006718966
          Length = 4300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VILLLED 8
            V+LLLED
Sbjct: 2701 VVLLLED 2707
>NP_001161210
          Length = 1483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    PVILLLED 8
            P+++LL+D
Sbjct: 1228 PLVILLDD 1235
>NP_065176
          Length = 1877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    PVILLLED 8
            P+++LL+D
Sbjct: 1622 PLVILLDD 1629
>NP_001032409
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P++L +ED
Sbjct: 586 PIVLAIED 593
>XP_006711674
          Length = 1385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    PVILLLED 8
            P+++LL+D
Sbjct: 1130 PLVILLDD 1137
>XP_006711673
          Length = 1549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    PVILLLED 8
            P+++LL+D
Sbjct: 1294 PLVILLDD 1301
>XP_006711672
          Length = 1557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    PVILLLED 8
            P+++LL+D
Sbjct: 1302 PLVILLDD 1309
>XP_006711671
          Length = 2153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    PVILLLED 8
            P+++LL+D
Sbjct: 1898 PLVILLDD 1905
>XP_006711670
          Length = 2161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    PVILLLED 8
            P+++LL+D
Sbjct: 1906 PLVILLDD 1913
>XP_005245629
          Length = 2164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    PVILLLED 8
            P+++LL+D
Sbjct: 1909 PLVILLDD 1916
>NP_056499
          Length = 136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LL+E+
Sbjct: 124 PIVLLIEN 131
>NP_001032410
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P++L +ED
Sbjct: 586 PIVLAIED 593
>NP_055191
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P++L +ED
Sbjct: 586 PIVLAIED 593
>NP_001182156
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           PV+LLL D
Sbjct: 272 PVLLLLID 279
>NP_060106
          Length = 1214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           PV+LLL D
Sbjct: 272 PVLLLLID 279
>NP_060142
          Length = 1865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PVILLLE 7
           P ILLLE
Sbjct: 769 PAILLLE 775
>NP_940905
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 751 PIVLLLDN 758
>NP_001274748
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 751 PIVLLLDN 758
>NP_001274749
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 701 PIVLLLDN 708
>NP_115927
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PVILLLEDT 9
            PV+L  EDT
Sbjct: 1057 PVLLSEEDT 1065
>NP_001996
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P +LLL+D
Sbjct: 397 PPVLLLQD 404
>NP_001137257
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P +LLL+D
Sbjct: 339 PPVLLLQD 346
>NP_001269335
          Length = 225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PVILLLED 8
          P++ LLED
Sbjct: 87 PLVKLLED 94
>NP_065873
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 833 PIVLLLDN 840
>NP_001137255
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P +LLL+D
Sbjct: 339 PPVLLLQD 346
>NP_001258932
          Length = 1211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 788 PIVLLLDN 795
>NP_001137256
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P +LLL+D
Sbjct: 397 PPVLLLQD 404
>NP_862820
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           PV+++L+D
Sbjct: 214 PVVVILKD 221
>NP_001184188
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  PVILLLED 8
          PV+++L+D
Sbjct: 71 PVVVILKD 78
>NP_036513
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           PV+++L+D
Sbjct: 214 PVVVILKD 221
>XP_006723312
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           PV+LLL D
Sbjct: 187 PVLLLLID 194
>XP_006720645
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PVILLLE 7
           P ILLLE
Sbjct: 769 PAILLLE 775
>XP_005254546
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PVILLLE 7
           P ILLLE
Sbjct: 327 PAILLLE 333
>XP_005254545
          Length = 1864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PVILLLE 7
           P ILLLE
Sbjct: 769 PAILLLE 775
>XP_005254544
          Length = 1884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PVILLLE 7
           P ILLLE
Sbjct: 769 PAILLLE 775
>XP_005254543
          Length = 1885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PVILLLE 7
           P ILLLE
Sbjct: 769 PAILLLE 775
>XP_005254939
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P +LLL+D
Sbjct: 397 PPVLLLQD 404
>XP_005254938
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P +LLL+D
Sbjct: 339 PPVLLLQD 346
>XP_005254937
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P +LLL+D
Sbjct: 339 PPVLLLQD 346
>XP_005254934
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P +LLL+D
Sbjct: 397 PPVLLLQD 404
>XP_006717257
          Length = 1083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 660 PIVLLLDN 667
>XP_006717256
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 749 PIVLLLDN 756
>XP_005248763
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           PV+++L+D
Sbjct: 161 PVVVILKD 168
>XP_005248762
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           PV+++L+D
Sbjct: 161 PVVVILKD 168
>XP_005248761
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           PV+++L+D
Sbjct: 214 PVVVILKD 221
>XP_006711360
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 308 PIVLLLDN 315
>XP_006711359
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 361 PIVLLLDN 368
>XP_006711358
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 751 PIVLLLDN 758
>XP_006711357
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   PVILLLED 8
           P++LLL++
Sbjct: 751 PIVLLLDN 758
>NP_076419
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVILLLED 8
           P++ LLED
Sbjct: 117 PLVKLLED 124
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.151    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 583,460
Number of extensions: 997
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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