Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_001128715                                                           17    2528
NP_001128717                                                           17    2528
NP_001128716                                                           17    2528
NP_001008657                                                           17    2528
NP_000347                                                              17    2528
NP_001182070                                                           17    2528
XP_005268566                                                           17    2528
XP_005268565                                                           17    2528
XP_005268564                                                           17    2528
XP_005268563                                                           17    2528
XP_005268562                                                           17    2528
XP_005268561                                                           17    2528
XP_005268560                                                           17    2528
XP_005268559                                                           17    2528
XP_005254968                                                           15    9605
XP_005254967                                                           15    9605
XP_006720570                                                           15    9605
NP_006113                                                              15    9605

>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PVAVQIRAT 9
            PVA QIRAT
Sbjct: 2630 PVAGQIRAT 2638



>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PVAVQIRAT 9
            PVA QIRAT
Sbjct: 2630 PVAGQIRAT 2638



>NP_001128715
          Length = 1488

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>NP_001128717
          Length = 1412

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 517 PVAVQVKA 524



>NP_001128716
          Length = 1451

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>NP_001008657
          Length = 958

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>NP_000347
          Length = 1411

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 517 PVAVQVKA 524



>NP_001182070
          Length = 1450

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>XP_005268566
          Length = 994

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>XP_005268565
          Length = 995

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>XP_005268564
          Length = 1449

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 517 PVAVQVKA 524



>XP_005268563
          Length = 1488

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>XP_005268562
          Length = 1489

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>XP_005268561
          Length = 1525

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>XP_005268560
          Length = 1525

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>XP_005268559
          Length = 1526

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   PVAVQIRA 8
           PVAVQ++A
Sbjct: 594 PVAVQVKA 601



>XP_005254968
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVAVQIRA 8
           P+AVQI A
Sbjct: 682 PLAVQISA 689



>XP_005254967
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVAVQIRA 8
           P+AVQI A
Sbjct: 682 PLAVQISA 689



>XP_006720570
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVAVQIRA 8
           P+AVQI A
Sbjct: 682 PLAVQISA 689



>NP_006113
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PVAVQIRA 8
           P+AVQI A
Sbjct: 682 PLAVQISA 689



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.129    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 322,435
Number of extensions: 358
Number of successful extensions: 20
Number of sequences better than 10000.0: 20
Number of HSP's gapped: 20
Number of HSP's successfully gapped: 20
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)