Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              20     509
XP_005248577                                                           20     509
XP_005248576                                                           20     509
NP_579920                                                              17    4312
NP_579919                                                              17    4312
NP_579918                                                              17    4312
NP_579916                                                              17    4312
NP_001265551                                                           17    4312
XP_005276831                                                           17    4312
NP_002864                                                              17    4312
NP_579921                                                              17    4312
NP_579922                                                              17    4312
NP_579917                                                              17    4312
NP_001495                                                              16    7355
NP_001136269                                                           16    7355
NP_055325                                                              16    7355
NP_149015                                                              16    7355
XP_005262314                                                           16    7355
XP_005262313                                                           16    7355
XP_006715989                                                           16    7355
NP_001243092                                                           15    9605
NP_001243095                                                           15    9605
NP_001157                                                              15    9605
NP_997639                                                              15    9605
NP_002017                                                              15    9605
NP_997643                                                              15    9605
NP_997647                                                              15    9605
NP_997641                                                              15    9605
NP_002301                                                              15    9605
NP_001121143                                                           15    9605
NP_001156                                                              15    9605
NP_892007                                                              15    9605
NP_870987                                                              15    9605
NP_001120930                                                           15    9605
NP_653165                                                              15    9605
XP_005260795                                                           15    9605
XP_005260794                                                           15    9605
XP_006723643                                                           15    9605
XP_006723642                                                           15    9605
XP_006716781                                                           15    9605
XP_005251409                                                           15    9605
XP_005251408                                                           15    9605
XP_006716780                                                           15    9605
XP_005246474                                                           15    9605
XP_005246473                                                           15    9605
XP_005246472                                                           15    9605
XP_005246471                                                           15    9605
XP_005246470                                                           15    9605
XP_005246469                                                           15    9605
XP_005246468                                                           15    9605
XP_005246467                                                           15    9605
XP_005246466                                                           15    9605
XP_005246465                                                           15    9605
XP_005246464                                                           15    9605
XP_005246463                                                           15    9605
XP_005246462                                                           15    9605
XP_005246461                                                           15    9605
XP_005246460                                                           15    9605
XP_005246459                                                           15    9605
XP_005246458                                                           15    9605
XP_005246457                                                           15    9605
XP_005246456                                                           15    9605
XP_005246455                                                           15    9605
XP_005246454                                                           15    9605
NP_061968                                                              15    9605
NP_113645                                                              15    9605
>NP_005912
          Length = 1512

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PV DTILVK
Sbjct: 682 PVVDTILVK 690
>XP_005248577
          Length = 1349

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PV DTILVK
Sbjct: 519 PVVDTILVK 527
>XP_005248576
          Length = 1375

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PV DTILVK
Sbjct: 545 PVVDTILVK 553
>NP_579920
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 278 PVAPTIMMK 286
>NP_579919
          Length = 584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 192 PVAPTIMMK 200
>NP_579918
          Length = 505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 113 PVAPTIMMK 121
>NP_579916
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 278 PVAPTIMMK 286
>NP_001265551
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 278 PVAPTIMMK 286
>XP_005276831
          Length = 505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 113 PVAPTIMMK 121
>NP_002864
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 278 PVAPTIMMK 286
>NP_579921
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 278 PVAPTIMMK 286
>NP_579922
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 278 PVAPTIMMK 286
>NP_579917
          Length = 681

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PVADTILVK 9
           PVA TI++K
Sbjct: 289 PVAPTIMMK 297
>NP_001495
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VADTILV 8
           VADT+LV
Sbjct: 97  VADTLLV 103
>NP_001136269
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VADTILV 8
           VADT+LV
Sbjct: 144 VADTLLV 150
>NP_055325
          Length = 4935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    PVADTI 6
            PVADT+
Sbjct: 2284 PVADTV 2289
>NP_149015
          Length = 5142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    PVADTI 6
            PVADT+
Sbjct: 2284 PVADTV 2289
>XP_005262314
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VADTILV 8
           VADT+LV
Sbjct: 107 VADTLLV 113
>XP_005262313
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VADTILV 8
           VADT+LV
Sbjct: 107 VADTLLV 113
>XP_006715989
          Length = 5148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    PVADTI 6
            PVADT+
Sbjct: 2284 PVADTV 2289
>NP_001243092
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DTILVK 9
           DTILVK
Sbjct: 511 DTILVK 516
>NP_001243095
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DTILVK 9
           DTILVK
Sbjct: 462 DTILVK 467
>NP_001157
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DTILVK 9
           DTILVK
Sbjct: 511 DTILVK 516
>NP_997639
          Length = 2176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>NP_002017
          Length = 2355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>NP_997643
          Length = 2330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>NP_997647
          Length = 2477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>NP_997641
          Length = 2296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>NP_002301
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ADTILVK 9
           AD+ILVK
Sbjct: 737 ADSILVK 743
>NP_001121143
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ADTILVK 9
           AD+ILVK
Sbjct: 737 ADSILVK 743
>NP_001156
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DTILVK 9
           DTILVK
Sbjct: 497 DTILVK 502
>NP_892007
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DTILVK 9
           DTILVK
Sbjct: 497 DTILVK 502
>NP_870987
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PVADTIL 7
           P++DT+L
Sbjct: 349 PISDTLL 355
>NP_001120930
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PVADTILV 8
          P+AD IL+
Sbjct: 71 PLADKILI 78
>NP_653165
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  PVADTILV 8
          P+A+TIL+
Sbjct: 85 PLAETILL 92
>XP_005260795
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PVADTILV 8
          P+AD IL+
Sbjct: 59 PLADKILI 66
>XP_005260794
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PVADTILV 8
          P+AD IL+
Sbjct: 59 PLADKILI 66
>XP_006723643
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PVADTILV 8
          P+AD IL+
Sbjct: 59 PLADKILI 66
>XP_006723642
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVADTILV 8
           P+AD IL+
Sbjct: 170 PLADKILI 177
>XP_006716781
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PVADTIL 7
           P++DT+L
Sbjct: 175 PISDTLL 181
>XP_005251409
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PVADTIL 7
           P++DT+L
Sbjct: 349 PISDTLL 355
>XP_005251408
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PVADTIL 7
           P++DT+L
Sbjct: 349 PISDTLL 355
>XP_006716780
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PVADTIL 7
           P++DT+L
Sbjct: 349 PISDTLL 355
>XP_005246474
          Length = 2240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246473
          Length = 2246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246472
          Length = 2265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246471
          Length = 2266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246470
          Length = 2267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246469
          Length = 2271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246468
          Length = 2273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246467
          Length = 2337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246466
          Length = 2361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246465
          Length = 2362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246464
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246463
          Length = 2386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246462
          Length = 2387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246461
          Length = 2392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246460
          Length = 2393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246459
          Length = 2421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246458
          Length = 2427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246457
          Length = 2446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246456
          Length = 2452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246455
          Length = 2458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>XP_005246454
          Length = 2483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PVADTIL 7
            P++DTI+
Sbjct: 1258 PISDTII 1264
>NP_061968
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PVADTILV 8
           P+AD IL+
Sbjct: 170 PLADKILI 177
>NP_113645
          Length = 250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  PVADTILV 8
          PVA+++LV
Sbjct: 9  PVANSVLV 16
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.139    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 416,291
Number of extensions: 639
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package