Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     299
XP_005262424                                                           20     299
NP_115642                                                              17    2528
NP_689483                                                              17    3301
NP_001098060                                                           17    3301
NP_001098059                                                           17    3301
NP_001098058                                                           17    3301
NP_001098057                                                           17    3301
XP_005258125                                                           17    3301
XP_006722234                                                           17    3301
NP_001157862                                                           17    4312
NP_001157861                                                           17    4312
NP_001157860                                                           17    4312
NP_001157859                                                           17    4312
NP_001157858                                                           17    4312
NP_057424                                                              17    4312
NP_775885                                                              16    5631
NP_001004060                                                           16    5631
NP_073606                                                              16    5631
NP_001036039                                                           16    5631
NP_001004067                                                           16    5631
NP_005389                                                              16    5631
XP_006725258                                                           16    5631
XP_006721059                                                           16    5631
XP_005255375                                                           16    5631
XP_005255025                                                           16    5631
XP_006710314                                                           16    5631
NP_055102                                                              16    5631
NP_068765                                                              15    9605
XP_005262513                                                           15    9605
XP_006724842                                                           15    9605
XP_006724841                                                           15    9605
XP_006724840                                                           15    9605
XP_005262512                                                           15    9605
XP_005262511                                                           15    9605
XP_006724839                                                           15    9605
XP_005262510                                                           15    9605
XP_005262509                                                           15    9605
XP_005266713                                                           15    9605
XP_005252430                                                           15    9605
NP_055728                                                              15    9605
>NP_722576
          Length = 3080

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    PTSQMVEF 8
            PTSQMVEF
Sbjct: 1856 PTSQMVEF 1863
>XP_005262424
          Length = 2875

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    PTSQMVEF 8
            PTSQMVEF
Sbjct: 1651 PTSQMVEF 1658
>NP_115642
          Length = 1984

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           PT QMVE+
Sbjct: 532 PTPQMVEY 539
>NP_689483
          Length = 901

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           P SQ+VEF
Sbjct: 208 PESQLVEF 215
>NP_001098060
          Length = 901

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           P SQ+VEF
Sbjct: 208 PESQLVEF 215
>NP_001098059
          Length = 901

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           P SQ+VEF
Sbjct: 208 PESQLVEF 215
>NP_001098058
          Length = 901

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           P SQ+VEF
Sbjct: 208 PESQLVEF 215
>NP_001098057
          Length = 901

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           P SQ+VEF
Sbjct: 208 PESQLVEF 215
>XP_005258125
          Length = 901

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           P SQ+VEF
Sbjct: 208 PESQLVEF 215
>XP_006722234
          Length = 901

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           P SQ+VEF
Sbjct: 208 PESQLVEF 215
>NP_001157862
          Length = 827

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PTSQMVEFS 9
           PT+ M++FS
Sbjct: 735 PTTSMLDFS 743
>NP_001157861
          Length = 1391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PTSQMVEFS 9
           PT+ M++FS
Sbjct: 735 PTTSMLDFS 743
>NP_001157860
          Length = 1504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PTSQMVEFS 9
           PT+ M++FS
Sbjct: 735 PTTSMLDFS 743
>NP_001157859
          Length = 1509

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PTSQMVEFS 9
           PT+ M++FS
Sbjct: 735 PTTSMLDFS 743
>NP_001157858
          Length = 1609

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PTSQMVEFS 9
           PT+ M++FS
Sbjct: 735 PTTSMLDFS 743
>NP_057424
          Length = 1601

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PTSQMVEFS 9
           PT+ M++FS
Sbjct: 735 PTTSMLDFS 743
>NP_775885
          Length = 1222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PTSQMVE 7
           P+SQM+E
Sbjct: 937 PSSQMIE 943
>NP_001004060
          Length = 1267

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PTSQMVE 7
           P+SQM+E
Sbjct: 937 PSSQMIE 943
>NP_073606
          Length = 619

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PTSQMV 6
           PTSQMV
Sbjct: 419 PTSQMV 424
>NP_001036039
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PTSQMV 6
           PTSQMV
Sbjct: 419 PTSQMV 424
>NP_001004067
          Length = 1222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PTSQMVE 7
           P+SQM+E
Sbjct: 937 PSSQMIE 943
>NP_005389
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PTSQMVEF 8
           PT Q +EF
Sbjct: 227 PTEQKIEF 234
>XP_006725258
          Length = 1267

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PTSQMVE 7
           P+SQM+E
Sbjct: 937 PSSQMIE 943
>XP_006721059
          Length = 294

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PTSQMVE 7
          P+SQM+E
Sbjct: 9  PSSQMIE 15
>XP_005255375
          Length = 1267

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PTSQMVE 7
           P+SQM+E
Sbjct: 937 PSSQMIE 943
>XP_005255025
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PTSQMV 6
           PTSQMV
Sbjct: 418 PTSQMV 423
>XP_006710314
          Length = 193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PTSQMVE 7
          P+SQM+E
Sbjct: 9  PSSQMIE 15
>NP_055102
          Length = 1222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PTSQMVE 7
           P+SQM+E
Sbjct: 937 PSSQMIE 943
>NP_068765
          Length = 1711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 862 PTSVVSEFS 870
>XP_005262513
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 862 PTSVVSEFS 870
>XP_006724842
          Length = 1687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 764 PTSVVSEFS 772
>XP_006724841
          Length = 1687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 764 PTSVVSEFS 772
>XP_006724840
          Length = 1785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 862 PTSVVSEFS 870
>XP_005262512
          Length = 1785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 862 PTSVVSEFS 870
>XP_005262511
          Length = 1785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 862 PTSVVSEFS 870
>XP_006724839
          Length = 1785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 862 PTSVVSEFS 870
>XP_005262510
          Length = 1785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 862 PTSVVSEFS 870
>XP_005262509
          Length = 1785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTSQMVEFS 9
           PTS + EFS
Sbjct: 862 PTSVVSEFS 870
>XP_005266713
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PTSQMVE 7
           PT QMV+
Sbjct: 477 PTGQMVQ 483
>XP_005252430
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PTSQMVEF 8
           PTS ++EF
Sbjct: 151 PTSVLMEF 158
>NP_055728
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PTSQMVE 7
           PT QMV+
Sbjct: 477 PTGQMVQ 483
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.116    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 463,910
Number of extensions: 898
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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