Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001156685                                                           22     103
NP_000133                                                              22     103
XP_006713936                                                           22     103
XP_006713935                                                           22     103
XP_006713934                                                           22     103
XP_006713933                                                           22     103
XP_006713932                                                           22     103
XP_006713931                                                           22     103
NP_001018054                                                           17    2528
NP_079328                                                              17    2528
XP_006712837                                                           17    2528
NP_000928                                                              17    3301
XP_005271659                                                           17    3301
XP_006718927                                                           17    3301
XP_006718926                                                           17    3301
XP_006718925                                                           17    3301
XP_005271658                                                           17    3301
NP_689811                                                              17    4312
NP_001275708                                                           17    4312
NP_001094345                                                           17    4312
NP_001275709                                                           17    4312
XP_005257163                                                           17    4312
XP_005257162                                                           17    4312
XP_005257160                                                           17    4312
XP_005257159                                                           17    4312
XP_005257157                                                           17    4312
XP_005257155                                                           17    4312
XP_005257154                                                           17    4312
XP_005257153                                                           17    4312
XP_005257152                                                           17    4312
NP_002325                                                              16    5631
XP_006718294                                                           16    5631
XP_005252980                                                           16    5631
NP_008986                                                              16    7355
NP_004317                                                              16    7355
NP_060059                                                              16    7355
NP_689837                                                              16    7355
NP_001229306                                                           16    7355
NP_699172                                                              16    7355
NP_001120833                                                           16    7355
NP_775922                                                              16    7355
XP_006717660                                                           16    7355
XP_005277475                                                           16    7355
XP_005277474                                                           16    7355
XP_006711546                                                           16    7355
XP_005273028                                                           16    7355
XP_006710421                                                           16    7355
XP_006710420                                                           16    7355
XP_005270517                                                           16    7355
XP_006710419                                                           16    7355
NP_001229854                                                           15    9605
NP_055673                                                              15    9605
NP_787106                                                              15    9605
NP_001070146                                                           15    9605
NP_005906                                                              15    9605
NP_002103                                                              15    9605
NP_689891                                                              15    9605
NP_054868                                                              15    9605
XP_006722795                                                           15    9605
XP_006722794                                                           15    9605
XP_006722793                                                           15    9605
XP_005259922                                                           15    9605
XP_005259921                                                           15    9605
XP_005250342                                                           15    9605
XP_005265000                                                           15    9605
XP_006713083                                                           15    9605
XP_006713082                                                           15    9605
XP_005245743                                                           15    9605
XP_005245742                                                           15    9605
XP_006711757                                                           15    9605
XP_005245741                                                           15    9605
NP_658988                                                              15    9605
>NP_001156685
          Length = 808

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PTMHKISRF 9
           PT+HKISRF
Sbjct: 411 PTVHKISRF 419
>NP_000133
          Length = 806

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PTMHKISRF 9
           PT+HKISRF
Sbjct: 409 PTVHKISRF 417
>XP_006713936
          Length = 807

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PTMHKISRF 9
           PT+HKISRF
Sbjct: 409 PTVHKISRF 417
>XP_006713935
          Length = 807

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PTMHKISRF 9
           PT+HKISRF
Sbjct: 409 PTVHKISRF 417
>XP_006713934
          Length = 809

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PTMHKISRF 9
           PT+HKISRF
Sbjct: 411 PTVHKISRF 419
>XP_006713933
          Length = 810

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PTMHKISRF 9
           PT+HKISRF
Sbjct: 411 PTVHKISRF 419
>XP_006713932
          Length = 810

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PTMHKISRF 9
           PT+HKISRF
Sbjct: 411 PTVHKISRF 419
>XP_006713931
          Length = 811

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PTMHKISRF 9
           PT+HKISRF
Sbjct: 411 PTVHKISRF 419
>NP_001018054
          Length = 1215

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PTMHKIS 7
           PTMHK S
Sbjct: 449 PTMHKTS 455
>NP_079328
          Length = 1328

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PTMHKIS 7
           PTMHK S
Sbjct: 562 PTMHKTS 568
>XP_006712837
          Length = 1328

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PTMHKIS 7
           PTMHK S
Sbjct: 562 PTMHKTS 568
>NP_000928
          Length = 1970

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PTMHKIS 7
           PT+HK+S
Sbjct: 462 PTLHKMS 468
>XP_005271659
          Length = 195

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P MH++ R+
Sbjct: 180 PAMHRLDRY 188
>XP_006718927
          Length = 229

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P MH++ R+
Sbjct: 214 PAMHRLDRY 222
>XP_006718926
          Length = 229

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P MH++ R+
Sbjct: 214 PAMHRLDRY 222
>XP_006718925
          Length = 229

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P MH++ R+
Sbjct: 214 PAMHRLDRY 222
>XP_005271658
          Length = 229

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P MH++ R+
Sbjct: 214 PAMHRLDRY 222
>NP_689811
          Length = 808

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 311 PSHHKRSRF 319
>NP_001275708
          Length = 846

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 349 PSHHKRSRF 357
>NP_001094345
          Length = 808

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 311 PSHHKRSRF 319
>NP_001275709
          Length = 799

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 310 PSHHKRSRF 318
>XP_005257163
          Length = 752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 238 PSHHKRSRF 246
>XP_005257162
          Length = 786

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 349 PSHHKRSRF 357
>XP_005257160
          Length = 799

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 310 PSHHKRSRF 318
>XP_005257159
          Length = 824

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 310 PSHHKRSRF 318
>XP_005257157
          Length = 825

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 311 PSHHKRSRF 319
>XP_005257155
          Length = 862

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 348 PSHHKRSRF 356
>XP_005257154
          Length = 863

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 349 PSHHKRSRF 357
>XP_005257153
          Length = 863

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 349 PSHHKRSRF 357
>XP_005257152
          Length = 863

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           P+ HK SRF
Sbjct: 349 PSHHKRSRF 357
>NP_002325
          Length = 1905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TMHKISR 8
            T+H+ISR
Sbjct: 1101 TLHRISR 1107
>XP_006718294
          Length = 1808

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TMHKISR 8
            T+H+ISR
Sbjct: 1101 TLHRISR 1107
>XP_005252980
          Length = 1809

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TMHKISR 8
            T+H+ISR
Sbjct: 1101 TLHRISR 1107
>NP_008986
          Length = 1390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PTMHKIS 7
           P++HK+S
Sbjct: 466 PSLHKLS 472
>NP_004317
          Length = 1426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PTMHKI 6
           PTMH++
Sbjct: 866 PTMHQV 871
>NP_060059
          Length = 223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   PTMHKISR 8
           P MH++ R
Sbjct: 214 PAMHRLDR 221
>NP_689837
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PTMHKISR 8
           PT+ K+SR
Sbjct: 263 PTVEKLSR 270
>NP_001229306
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PTMHKISR 8
           PT+ K+SR
Sbjct: 263 PTVEKLSR 270
>NP_699172
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   PTMHKISRF 9
           P MHK   F
Sbjct: 183 PLMHKYEEF 191
>NP_001120833
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   PTMHKISRF 9
           P MHK   F
Sbjct: 183 PLMHKYEEF 191
>NP_775922
          Length = 6996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PTMHKISR 8
            P MHK+ R
Sbjct: 5980 PPMHKMMR 5987
>XP_006717660
          Length = 1369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PTMHKIS 7
           P++HK+S
Sbjct: 445 PSLHKLS 451
>XP_005277475
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PTMHKI 6
           PTMH++
Sbjct: 792 PTMHQV 797
>XP_005277474
          Length = 1414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PTMHKI 6
           PTMH++
Sbjct: 866 PTMHQV 871
>XP_006711546
          Length = 1426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PTMHKI 6
           PTMH++
Sbjct: 866 PTMHQV 871
>XP_005273028
          Length = 1426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PTMHKI 6
           PTMH++
Sbjct: 866 PTMHQV 871
>XP_006710421
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   PTMHKISRF 9
           P MHK   F
Sbjct: 183 PLMHKYEEF 191
>XP_006710420
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   PTMHKISRF 9
           P MHK   F
Sbjct: 183 PLMHKYEEF 191
>XP_005270517
          Length = 731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   PTMHKISRF 9
           P MHK   F
Sbjct: 183 PLMHKYEEF 191
>XP_006710419
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   PTMHKISRF 9
           P MHK   F
Sbjct: 183 PLMHKYEEF 191
>NP_001229854
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  PTMHKIS 7
          P MH++S
Sbjct: 49 PEMHRVS 55
>NP_055673
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   PTMHKIS 7
           P MH++S
Sbjct: 127 PEMHRVS 133
>NP_787106
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PTMHKI 6
           PT HKI
Sbjct: 208 PTKHKI 213
>NP_001070146
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PTMHKI 6
           PT HKI
Sbjct: 336 PTKHKI 341
>NP_005906
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PTMHKI 6
           PT HKI
Sbjct: 118 PTRHKI 123
>NP_002103
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TMHKISRF 9
           T HK+S F
Sbjct: 561 TKHKLSSF 568
>NP_689891
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           PT+H++  F
Sbjct: 264 PTVHEVDIF 272
>NP_054868
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  PTMHKI 6
          PT+HK+
Sbjct: 82 PTIHKL 87
>XP_006722795
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PTMHKI 6
           PT HKI
Sbjct: 337 PTKHKI 342
>XP_006722794
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PTMHKI 6
           PT HKI
Sbjct: 337 PTKHKI 342
>XP_006722793
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PTMHKI 6
           PT HKI
Sbjct: 208 PTKHKI 213
>XP_005259922
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PTMHKI 6
           PT HKI
Sbjct: 263 PTKHKI 268
>XP_005259921
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PTMHKI 6
           PT HKI
Sbjct: 337 PTKHKI 342
>XP_005250342
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  PTMHKI 6
          PT+HK+
Sbjct: 82 PTIHKL 87
>XP_005265000
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           PT+H++  F
Sbjct: 264 PTVHEVDIF 272
>XP_006713083
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           PT+H++  F
Sbjct: 198 PTVHEVDIF 206
>XP_006713082
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PTMHKISRF 9
           PT+H++  F
Sbjct: 263 PTVHEVDIF 271
>XP_005245743
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   PTMHKIS 7
           P MH++S
Sbjct: 127 PEMHRVS 133
>XP_005245742
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  PTMHKIS 7
          P MH++S
Sbjct: 49 PEMHRVS 55
>XP_006711757
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  PTMHKIS 7
          P MH++S
Sbjct: 49 PEMHRVS 55
>XP_005245741
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  PTMHKIS 7
          P MH++S
Sbjct: 49 PEMHRVS 55
>NP_658988
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TMHKISRF 9
           T+H +SR+
Sbjct: 796 TLHALSRY 803
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.137    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 582,954
Number of extensions: 1009
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package