Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     509
NP_001087241                                                           20     509
XP_005265799                                                           20     509
XP_005265798                                                           20     509
XP_005265797                                                           20     509
NP_060597                                                              17    3301
NP_001159434                                                           17    3301
NP_776065                                                              17    3301
NP_076991                                                              17    3301
NP_059119                                                              17    4312
XP_005263119                                                           17    4312
NP_061728                                                              16    5631
NP_113683                                                              16    5631
NP_113684                                                              16    5631
NP_079146                                                              16    7355
NP_004455                                                              16    7355
NP_061122                                                              15    9605
NP_001363                                                              15    9605
NP_060024                                                              15    9605
NP_001138696                                                           15    9605
XP_006721528                                                           15    9605
XP_006720669                                                           15    9605
XP_006720667                                                           15    9605
NP_001033729                                                           15    9605
>NP_000213
          Length = 976

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PTFKQSVQL 9
           PTFKQ VQL
Sbjct: 915 PTFKQIVQL 923
>NP_001087241
          Length = 972

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PTFKQSVQL 9
           PTFKQ VQL
Sbjct: 911 PTFKQIVQL 919
>XP_005265799
          Length = 973

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PTFKQSVQL 9
           PTFKQ VQL
Sbjct: 912 PTFKQIVQL 920
>XP_005265798
          Length = 976

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PTFKQSVQL 9
           PTFKQ VQL
Sbjct: 915 PTFKQIVQL 923
>XP_005265797
          Length = 977

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PTFKQSVQL 9
           PTFKQ VQL
Sbjct: 916 PTFKQIVQL 924
>NP_060597
          Length = 826

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTFKQSVQ 8
           P F+QSVQ
Sbjct: 454 PNFQQSVQ 461
>NP_001159434
          Length = 786

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTFKQSVQ 8
           P F+QSVQ
Sbjct: 414 PNFQQSVQ 421
>NP_776065
          Length = 825

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PTFKQSVQ 8
           P F+QSVQ
Sbjct: 453 PNFQQSVQ 460
>NP_076991
          Length = 562

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PTFKQSVQL 9
          P FKQ VQ+
Sbjct: 28 PDFKQHVQI 36
>NP_059119
          Length = 657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PTFKQSVQ 8
           P FKQ++Q
Sbjct: 160 PEFKQAIQ 167
>XP_005263119
          Length = 657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PTFKQSVQ 8
           P FKQ++Q
Sbjct: 160 PEFKQAIQ 167
>NP_061728
          Length = 948

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PTFKQSV 7
           PTF QSV
Sbjct: 240 PTFAQSV 246
>NP_113683
          Length = 824

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PTFKQSV 7
           PTF QSV
Sbjct: 240 PTFAQSV 246
>NP_113684
          Length = 808

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PTFKQSV 7
           PTF QSV
Sbjct: 240 PTFAQSV 246
>NP_079146
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PTFKQS 6
           PTFKQ+
Sbjct: 916 PTFKQA 921
>NP_004455
          Length = 268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PTFKQSVQ 8
           P FKQS Q
Sbjct: 217 PRFKQSEQ 224
>NP_061122
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTFKQSVQL 9
           PT +Q VQL
Sbjct: 678 PTVQQIVQL 686
>NP_001363
          Length = 4486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    PTFKQSV 7
            PT KQS+
Sbjct: 3005 PTVKQSI 3011
>NP_060024
          Length = 1801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TFKQSVQL 9
          TFK +VQL
Sbjct: 82 TFKLTVQL 89
>NP_001138696
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTFKQSVQL 9
           PT +Q VQL
Sbjct: 678 PTVQQIVQL 686
>XP_006721528
          Length = 3869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    PTFKQSV 7
            PT KQS+
Sbjct: 3005 PTVKQSI 3011
>XP_006720669
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTFKQSVQL 9
           PT +Q VQL
Sbjct: 549 PTVQQIVQL 557
>XP_006720667
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTFKQSVQL 9
           PT +Q VQL
Sbjct: 669 PTVQQIVQL 677
>NP_001033729
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PTFKQSVQL 9
           PT +Q VQL
Sbjct: 678 PTVQQIVQL 686
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.127    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 365,354
Number of extensions: 471
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package