Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              20     509
XP_005268094                                                           20     509
NP_001070254                                                           17    2528
XP_006718388                                                           17    2528
XP_006718387                                                           17    2528
XP_006718386                                                           17    2528
NP_003731                                                              17    3301
XP_006715298                                                           17    3301
XP_005249513                                                           17    3301
XP_005256084                                                           16    5631
XP_005256083                                                           16    5631
XP_005256082                                                           16    5631
NP_060766                                                              16    5631
NP_000209                                                              16    7355
NP_861463                                                              16    7355
NP_115582                                                              16    7355
NP_001018088                                                           16    7355
NP_004948                                                              16    7355
NP_001275732                                                           16    7355
NP_001092268                                                           16    7355
NP_001092267                                                           16    7355
NP_001092266                                                           16    7355
NP_005759                                                              16    7355
NP_065961                                                              16    7355
NP_001158137                                                           16    7355
XP_005260643                                                           16    7355
XP_006723947                                                           16    7355
XP_006721363                                                           16    7355
XP_005256258                                                           16    7355
XP_005256257                                                           16    7355
XP_005256256                                                           16    7355
XP_005256255                                                           16    7355
XP_006721362                                                           16    7355
XP_006721361                                                           16    7355
XP_005256254                                                           16    7355
XP_005256253                                                           16    7355
XP_005256252                                                           16    7355
XP_005256251                                                           16    7355
XP_006721360                                                           16    7355
XP_005256250                                                           16    7355
XP_005251921                                                           16    7355
XP_006716134                                                           16    7355
NP_116272                                                              16    7355
NP_055661                                                              15    9605
NP_001171761                                                           15    9605
NP_000329                                                              15    9605
NP_001012241                                                           15    9605
NP_001073981                                                           15    9605
XP_005257356                                                           15    9605
XP_005257355                                                           15    9605
XP_006720719                                                           15    9605
XP_005254663                                                           15    9605
XP_005254662                                                           15    9605
XP_005270226                                                           15    9605
XP_005270225                                                           15    9605
XP_005270224                                                           15    9605
XP_005270223                                                           15    9605
XP_005251177                                                           15    9605
>NP_000360
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PSLLEVSQT 9
           PSLL+VSQT
Sbjct: 228 PSLLDVSQT 236
>XP_005268094
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PSLLEVSQT 9
           PSLL+VSQT
Sbjct: 228 PSLLDVSQT 236
>NP_001070254
          Length = 1735

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PSLLEVSQT 9
           PSLL VSQ+
Sbjct: 333 PSLLSVSQS 341
>XP_006718388
          Length = 1331

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PSLLEVSQT 9
           PSLL VSQ+
Sbjct: 396 PSLLSVSQS 404
>XP_006718387
          Length = 1798

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PSLLEVSQT 9
           PSLL VSQ+
Sbjct: 396 PSLLSVSQS 404
>XP_006718386
          Length = 1822

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PSLLEVSQT 9
           PSLL VSQ+
Sbjct: 396 PSLLSVSQS 404
>NP_003731
          Length = 499

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PSLLEVSQT 9
           P+L EVSQT
Sbjct: 353 PTLEEVSQT 361
>XP_006715298
          Length = 317

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PSLLEVSQT 9
           P+L EVSQT
Sbjct: 171 PTLEEVSQT 179
>XP_005249513
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PSLLEVSQT 9
           P+L EVSQT
Sbjct: 350 PTLEEVSQT 358
>XP_005256084
          Length = 594

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  PSLLEVSQ 8
          PSL+EVS+
Sbjct: 85 PSLVEVSR 92
>XP_005256083
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  PSLLEVSQ 8
          PSL+EVS+
Sbjct: 85 PSLVEVSR 92
>XP_005256082
          Length = 647

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  PSLLEVSQ 8
          PSL+EVS+
Sbjct: 85 PSLVEVSR 92
>NP_060766
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  PSLLEVSQ 8
          PSL+EVS+
Sbjct: 85 PSLVEVSR 92
>NP_000209
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PSLLEVS 7
           P+LLEVS
Sbjct: 469 PTLLEVS 475
>NP_861463
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PSLLEVS 7
           P+LLEVS
Sbjct: 342 PTLLEVS 348
>NP_115582
          Length = 1866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>NP_001018088
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           P+L EVS T
Sbjct: 390 PNLTEVSST 398
>NP_004948
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           P+L EVS T
Sbjct: 440 PNLTEVSST 448
>NP_001275732
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           P+L EVS T
Sbjct: 414 PNLTEVSST 422
>NP_001092268
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PSLLEVSQT 9
          P LL  SQT
Sbjct: 57 PELLSTSQT 65
>NP_001092267
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PSLLEVSQT 9
          P LL  SQT
Sbjct: 48 PELLSTSQT 56
>NP_001092266
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PSLLEVSQT 9
          P LL  SQT
Sbjct: 6  PELLSTSQT 14
>NP_005759
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PSLLEVS 7
           PSLLEV+
Sbjct: 182 PSLLEVA 188
>NP_065961
          Length = 1934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PSLLEVSQ 8
           PSL EVSQ
Sbjct: 302 PSLGEVSQ 309
>NP_001158137
          Length = 1950

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PSLLEVSQ 8
           PSL EVSQ
Sbjct: 302 PSLGEVSQ 309
>XP_005260643
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PSLLEVSQT 9
          P LL  SQT
Sbjct: 57 PELLSTSQT 65
>XP_006723947
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PSLLEVSQT 9
          P LL  SQT
Sbjct: 57 PELLSTSQT 65
>XP_006721363
          Length = 1385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_005256258
          Length = 1397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1136 SLLQLSQT 1143
>XP_005256257
          Length = 1405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_005256256
          Length = 1427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_005256255
          Length = 1809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_006721362
          Length = 1810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_006721361
          Length = 1836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1136 SLLQLSQT 1143
>XP_005256254
          Length = 1837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_005256253
          Length = 1838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1138 SLLQLSQT 1145
>XP_005256252
          Length = 1865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_005256251
          Length = 1866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_006721360
          Length = 1866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_005256250
          Length = 1866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLLEVSQT 9
            SLL++SQT
Sbjct: 1166 SLLQLSQT 1173
>XP_005251921
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           P+L EVS T
Sbjct: 440 PNLTEVSST 448
>XP_006716134
          Length = 1847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PSLLEVSQ 8
           PSL EVSQ
Sbjct: 226 PSLGEVSQ 233
>NP_116272
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PSLLEVSQT 9
          P LL  SQT
Sbjct: 6  PELLSTSQT 14
>NP_055661
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PSLLEVSQ 8
           P LL VSQ
Sbjct: 606 PDLLSVSQ 613
>NP_001171761
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PSLLEVSQ 8
           PSLLE+ +
Sbjct: 129 PSLLEIHE 136
>NP_000329
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PSLLEVSQ 8
           PSLLE+ +
Sbjct: 129 PSLLEIHE 136
>NP_001012241
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PSLLEVSQT 9
          P L E SQT
Sbjct: 43 PELSETSQT 51
>NP_001073981
          Length = 974

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           PS+  +SQT
Sbjct: 226 PSIQHISQT 234
>XP_005257356
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PSLLEVSQT 9
           P L E SQT
Sbjct: 306 PELSETSQT 314
>XP_005257355
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PSLLEVSQT 9
           P L E SQT
Sbjct: 306 PELSETSQT 314
>XP_006720719
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PSLLEVSQ 8
           PSLLE+ +
Sbjct: 129 PSLLEIHE 136
>XP_005254663
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PSLLEVSQ 8
           PSLLE+ +
Sbjct: 129 PSLLEIHE 136
>XP_005254662
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PSLLEVSQ 8
           PSLLE+ +
Sbjct: 129 PSLLEIHE 136
>XP_005270226
          Length = 927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           PS+  +SQT
Sbjct: 179 PSIQHISQT 187
>XP_005270225
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           PS+  +SQT
Sbjct: 226 PSIQHISQT 234
>XP_005270224
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           PS+  +SQT
Sbjct: 226 PSIQHISQT 234
>XP_005270223
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PSLLEVSQT 9
           PS+  +SQT
Sbjct: 226 PSIQHISQT 234
>XP_005251177
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PSLLEVSQ 8
           P LL VSQ
Sbjct: 458 PDLLSVSQ 465
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.117    0.284 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 423,787
Number of extensions: 677
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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