Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065386                                                              17    3301
XP_005268986                                                           17    3301
XP_006712163                                                           17    3301
XP_005264606                                                           17    3301
XP_006712161                                                           17    3301
XP_005264605                                                           17    3301
XP_005264604                                                           17    3301
NP_542942                                                              17    4312
XP_006725464                                                           17    4312
XP_006725463                                                           17    4312
XP_005261395                                                           17    4312
NP_001073964                                                           16    5631
NP_258428                                                              16    5631
NP_001007467                                                           16    5631
NP_064630                                                              16    5631
NP_001001890                                                           16    5631
NP_001745                                                              16    5631
NP_848593                                                              16    5631
XP_005261126                                                           16    5631
XP_005261125                                                           16    5631
XP_006718220                                                           16    5631
XP_006718219                                                           16    5631
XP_006718218                                                           16    5631
XP_006715861                                                           16    5631
XP_006715860                                                           16    5631
XP_005267114                                                           16    5631
NP_057520                                                              16    7355
NP_776175                                                              16    7355
NP_064505                                                              16    7355
NP_115791                                                              16    7355
NP_690851                                                              16    7355
NP_001156794                                                           16    7355
NP_001156793                                                           16    7355
XP_005255298                                                           16    7355
XP_005254368                                                           16    7355
XP_005254367                                                           16    7355
XP_006720536                                                           16    7355
XP_006715858                                                           16    7355
XP_006715857                                                           16    7355
XP_006712699                                                           16    7355
XP_006712698                                                           16    7355
XP_006712697                                                           16    7355
NP_443143                                                              15    9605
XP_006722442                                                           15    9605
NP_208382                                                              15    9605
NP_001012986                                                           15    9605
>NP_065386
          Length = 179

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   RLSSRLST 9
           RLS+RLST
Sbjct: 124 RLSNRLST 131
>XP_005268986
          Length = 179

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   RLSSRLST 9
           RLS+RLST
Sbjct: 124 RLSNRLST 131
>XP_006712163
          Length = 363

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PRLS RLS
Sbjct: 300 PRLSPRLS 307
>XP_005264606
          Length = 399

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PRLS RLS
Sbjct: 336 PRLSPRLS 343
>XP_006712161
          Length = 399

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PRLS RLS
Sbjct: 336 PRLSPRLS 343
>XP_005264605
          Length = 407

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PRLS RLS
Sbjct: 344 PRLSPRLS 351
>XP_005264604
          Length = 412

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PRLS RLS
Sbjct: 349 PRLSPRLS 356
>NP_542942
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PRLSSRLST 9
           PR+S +LST
Sbjct: 169 PRVSKQLST 177
>XP_006725464
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PRLSSRLST 9
           PR+S +LST
Sbjct: 169 PRVSKQLST 177
>XP_006725463
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PRLSSRLST 9
           PR+S +LST
Sbjct: 169 PRVSKQLST 177
>XP_005261395
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PRLSSRLST 9
           PR+S +LST
Sbjct: 169 PRVSKQLST 177
>NP_001073964
          Length = 2968

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PRL+ RLS
Sbjct: 256 PRLAERLS 263
>NP_258428
          Length = 779

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  PRLSSRL 7
          PRL+SRL
Sbjct: 56 PRLASRL 62
>NP_001007467
          Length = 678

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   PRLSSRLST 9
           PRL S LST
Sbjct: 402 PRLCSYLST 410
>NP_064630
          Length = 1543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   PRLSSRLST 9
           PRL S LST
Sbjct: 402 PRLCSYLST 410
>NP_001001890
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSSRLST 9
           LSSRLST
Sbjct: 290 LSSRLST 296
>NP_001745
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSSRLST 9
           LSSRLST
Sbjct: 317 LSSRLST 323
>NP_848593
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PRLSSRLST 9
           P LS +LST
Sbjct: 370 PHLSDKLST 378
>XP_005261126
          Length = 416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSSRLST 9
           LSSRLST
Sbjct: 253 LSSRLST 259
>XP_005261125
          Length = 468

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSSRLST 9
           LSSRLST
Sbjct: 305 LSSRLST 311
>XP_006718220
          Length = 391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PRLSSRLST 9
           P LS +LST
Sbjct: 370 PHLSDKLST 378
>XP_006718219
          Length = 417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PRLSSRLST 9
           P LS +LST
Sbjct: 370 PHLSDKLST 378
>XP_006718218
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PRLSSRLST 9
           P LS +LST
Sbjct: 259 PHLSDKLST 267
>XP_006715861
          Length = 2189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PRL+ RLS
Sbjct: 256 PRLAERLS 263
>XP_006715860
          Length = 2968

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PRL+ RLS
Sbjct: 256 PRLAERLS 263
>XP_005267114
          Length = 1543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   PRLSSRLST 9
           PRL S LST
Sbjct: 402 PRLCSYLST 410
>NP_057520
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RLSSRLST 9
           R SSRLST
Sbjct: 326 RRSSRLST 333
>NP_776175
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RLSSRLST 9
           RLS RLST
Sbjct: 553 RLSFRLST 560
>NP_064505
          Length = 1555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PRLSSRLST 9
           PR++SR+ T
Sbjct: 693 PRINSRILT 701
>NP_115791
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PR+S RLS
Sbjct: 883 PRVSPRLS 890
>NP_690851
          Length = 280

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PRLSSRL 7
          PR+SSR+
Sbjct: 31 PRMSSRI 37
>NP_001156794
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           P LS+RLS
Sbjct: 621 PELSARLS 628
>NP_001156793
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           P LS+RLS
Sbjct: 668 PELSARLS 675
>XP_005255298
          Length = 280

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PRLSSRL 7
          PR+SSR+
Sbjct: 31 PRMSSRI 37
>XP_005254368
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RLSSRLST 9
           RLS RLST
Sbjct: 553 RLSFRLST 560
>XP_005254367
          Length = 1031

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RLSSRLST 9
           RLS RLST
Sbjct: 434 RLSFRLST 441
>XP_006720536
          Length = 1072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RLSSRLST 9
           RLS RLST
Sbjct: 475 RLSFRLST 482
>XP_006715858
          Length = 1267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PRLSSRLS 8
            PR+S RLS
Sbjct: 996  PRVSPRLS 1003
>XP_006715857
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PRLSSRLS 8
            PR+S RLS
Sbjct: 997  PRVSPRLS 1004
>XP_006712699
          Length = 1544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PRLSSRLST 9
           PR++SR+ T
Sbjct: 682 PRINSRILT 690
>XP_006712698
          Length = 1547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PRLSSRLST 9
           PR++SR+ T
Sbjct: 693 PRINSRILT 701
>XP_006712697
          Length = 1549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PRLSSRLST 9
           PR++SR+ T
Sbjct: 687 PRINSRILT 695
>NP_443143
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PRLSSRLST 9
          P L +R+ST
Sbjct: 60 PELETRMST 68
>XP_006722442
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PRLSSRLST 9
          P L +R+ST
Sbjct: 60 PELETRMST 68
>NP_208382
          Length = 648

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PRLSSRL 7
          PRL SRL
Sbjct: 37 PRLRSRL 43
>NP_001012986
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRLSSRLS 8
           PR+ SRL+
Sbjct: 108 PRIDSRLA 115
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.120    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 317,506
Number of extensions: 463
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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