Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     509
NP_001035957                                                           20     509
XP_006721991                                                           20     509
XP_006721990                                                           20     509
XP_006721989                                                           20     509
XP_005258041                                                           20     509
XP_006721988                                                           20     509
XP_006721987                                                           20     509
XP_006721986                                                           20     509
XP_005258040                                                           20     509
XP_006721985                                                           20     509
NP_001269607                                                           18    1935
NP_001269606                                                           18    1935
NP_000457                                                              18    1935
NP_063945                                                              17    2528
XP_006717250                                                           17    2528
XP_005266151                                                           17    2528
NP_995317                                                              17    4312
NP_001345                                                              17    4312
NP_057078                                                              17    4312
NP_001128713                                                           17    4312
NP_065810                                                              17    4312
XP_006720684                                                           17    4312
XP_005276151                                                           17    4312
NP_001344                                                              17    4312
NP_002323                                                              16    5631
NP_000558                                                              16    5631
NP_079350                                                              16    5631
NP_006868                                                              16    5631
NP_001129663                                                           16    5631
NP_056308                                                              16    5631
XP_006714380                                                           16    5631
XP_006714379                                                           16    5631
XP_006714378                                                           16    5631
XP_006714377                                                           16    5631
NP_002903                                                              16    7355
NP_001273361                                                           16    7355
NP_001273360                                                           16    7355
XP_006715607                                                           16    7355
XP_006715606                                                           16    7355
NP_775889                                                              16    7355
NP_001269673                                                           15    9605
NP_001269664                                                           15    9605
NP_001269672                                                           15    9605
NP_056350                                                              15    9605
NP_001093893                                                           15    9605
NP_001093892                                                           15    9605
NP_001093894                                                           15    9605
NP_689812                                                              15    9605
NP_001099129                                                           15    9605
NP_065962                                                              15    9605
NP_057170                                                              15    9605
NP_775808                                                              15    9605
XP_005250743                                                           15    9605
XP_006716234                                                           15    9605
XP_005277669                                                           15    9605
XP_005277638                                                           15    9605
XP_005277637                                                           15    9605
XP_005277636                                                           15    9605
XP_005246517                                                           15    9605
XP_005246516                                                           15    9605
XP_006712473                                                           15    9605
XP_005246515                                                           15    9605
XP_005246513                                                           15    9605
XP_005246514                                                           15    9605
XP_006712472                                                           15    9605
XP_005246511                                                           15    9605
XP_006710416                                                           15    9605
XP_006710415                                                           15    9605
XP_005270511                                                           15    9605
XP_005270508                                                           15    9605
NP_001003795                                                           15    9605
>NP_000258
          Length = 2818

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1412 PRIERGLKL 1420
>NP_001035957
          Length = 2839

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1433 PRIERGLKL 1441
>XP_006721991
          Length = 1632

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1443 PRIERGLKL 1451
>XP_006721990
          Length = 2823

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1443 PRIERGLKL 1451
>XP_006721989
          Length = 2823

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1443 PRIERGLKL 1451
>XP_005258041
          Length = 2836

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1412 PRIERGLKL 1420
>XP_006721988
          Length = 2846

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1422 PRIERGLKL 1430
>XP_006721987
          Length = 2849

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1443 PRIERGLKL 1451
>XP_006721986
          Length = 2854

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1430 PRIERGLKL 1438
>XP_005258040
          Length = 2857

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1433 PRIERGLKL 1441
>XP_006721985
          Length = 2867

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PRIERSLKL 9
            PRIER LKL
Sbjct: 1443 PRIERGLKL 1451
>NP_001269607
          Length = 1075

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PRIERSLKL 9
           P+I RSLKL
Sbjct: 231 PKIPRSLKL 239
>NP_001269606
          Length = 1226

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PRIERSLKL 9
           P+I RSLKL
Sbjct: 439 PKIPRSLKL 447
>NP_000457
          Length = 1283

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PRIERSLKL 9
           P+I RSLKL
Sbjct: 439 PKIPRSLKL 447
>NP_063945
          Length = 644

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PRIERSLKL 9
          PR+ER+L L
Sbjct: 78 PRLERALSL 86
>XP_006717250
          Length = 610

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PRIERSLKL 9
          PR+ER+L L
Sbjct: 78 PRLERALSL 86
>XP_005266151
          Length = 643

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PRIERSLKL 9
          PR+ER+L L
Sbjct: 78 PRLERALSL 86
>NP_995317
          Length = 323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P +ERSLK
Sbjct: 97  PALERSLK 104
>NP_001345
          Length = 323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P +ERSLK
Sbjct: 97  PALERSLK 104
>NP_057078
          Length = 247

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PRIERSL 7
           PRIER+L
Sbjct: 178 PRIERTL 184
>NP_001128713
          Length = 139

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P +ERSLK
Sbjct: 97  PALERSLK 104
>NP_065810
          Length = 4700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PRIERSLK 8
            PR+ERS K
Sbjct: 2214 PRLERSSK 2221
>XP_006720684
          Length = 4713

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PRIERSLK 8
            PR+ERS K
Sbjct: 2227 PRLERSSK 2234
>XP_005276151
          Length = 146

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P +ERSLK
Sbjct: 97  PALERSLK 104
>NP_001344
          Length = 323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P +ERSLK
Sbjct: 97  PALERSLK 104
>NP_002323
          Length = 4544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PRIERS 6
            PRIERS
Sbjct: 2031 PRIERS 2036
>NP_000558
          Length = 224

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           PR+ +SLK
Sbjct: 133 PRVRKSLK 140
>NP_079350
          Length = 4012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PRIERSL 7
            PR++RSL
Sbjct: 3838 PRVQRSL 3844
>NP_006868
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PRIERSLKL 9
          PRI+  LKL
Sbjct: 2  PRIDADLKL 10
>NP_001129663
          Length = 851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PRIERSL 7
           PR+ER+L
Sbjct: 122 PRVERTL 128
>NP_056308
          Length = 859

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PRIERSL 7
           PR+ER+L
Sbjct: 122 PRVERTL 128
>XP_006714380
          Length = 3897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PRIERSL 7
            PR++RSL
Sbjct: 3723 PRVQRSL 3729
>XP_006714379
          Length = 3936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PRIERSL 7
            PR++RSL
Sbjct: 3762 PRVQRSL 3768
>XP_006714378
          Length = 3965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PRIERSL 7
            PR++RSL
Sbjct: 3791 PRVQRSL 3797
>XP_006714377
          Length = 4010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PRIERSL 7
            PR++RSL
Sbjct: 3836 PRVQRSL 3842
>NP_002903
          Length = 3130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IERSLKL 9
            +ERSLKL
Sbjct: 2870 LERSLKL 2876
>NP_001273361
          Length = 3052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IERSLKL 9
            +ERSLKL
Sbjct: 2792 LERSLKL 2798
>NP_001273360
          Length = 3052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IERSLKL 9
            +ERSLKL
Sbjct: 2792 LERSLKL 2798
>XP_006715607
          Length = 3052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IERSLKL 9
            +ERSLKL
Sbjct: 2792 LERSLKL 2798
>XP_006715606
          Length = 3130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IERSLKL 9
            +ERSLKL
Sbjct: 2870 LERSLKL 2876
>NP_775889
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PRIERSLKL 9
           PR+ R LK+
Sbjct: 164 PRLPRKLKM 172
>NP_001269673
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 249 PNIEKSVK 256
>NP_001269664
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 219 PNIEKSVK 226
>NP_001269672
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 159 PNIEKSVK 166
>NP_056350
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 219 PNIEKSVK 226
>NP_001093893
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 219 PNIEKSVK 226
>NP_001093892
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 219 PNIEKSVK 226
>NP_001093894
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 150 PNIEKSVK 157
>NP_689812
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PRIERSL 7
           PR+ER+L
Sbjct: 485 PRMERAL 491
>NP_001099129
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIERSLK 8
           R+ERS+K
Sbjct: 399 RLERSMK 405
>NP_065962
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RIERSLKL 9
            R+E+ LKL
Sbjct: 1347 RVEKGLKL 1354
>NP_057170
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PRIERSLKL 9
           P+I++ LK+
Sbjct: 179 PKIQKDLKI 187
>NP_775808
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIERSLK 8
           R+E+SLK
Sbjct: 598 RVEKSLK 604
>XP_005250743
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RIERSLKL 9
            R+E+ LKL
Sbjct: 1347 RVEKGLKL 1354
>XP_006716234
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RIERSLKL 9
            R+E+ LKL
Sbjct: 1347 RVEKGLKL 1354
>XP_005277669
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIERSLK 8
           R+E+SLK
Sbjct: 598 RVEKSLK 604
>XP_005277638
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIERSLK 8
           R+E+SLK
Sbjct: 404 RVEKSLK 410
>XP_005277637
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIERSLK 8
           R+E+SLK
Sbjct: 527 RVEKSLK 533
>XP_005277636
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIERSLK 8
           R+E+SLK
Sbjct: 598 RVEKSLK 604
>XP_005246517
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 150 PNIEKSVK 157
>XP_005246516
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 150 PNIEKSVK 157
>XP_006712473
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 203 PNIEKSVK 210
>XP_005246515
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 219 PNIEKSVK 226
>XP_005246513
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 219 PNIEKSVK 226
>XP_005246514
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 219 PNIEKSVK 226
>XP_006712472
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 272 PNIEKSVK 279
>XP_005246511
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PRIERSLK 8
           P IE+S+K
Sbjct: 272 PNIEKSVK 279
>XP_006710416
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RIERSLK 8
          R+ERS+K
Sbjct: 79 RLERSMK 85
>XP_006710415
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RIERSLK 8
          R+ERS+K
Sbjct: 79 RLERSMK 85
>XP_005270511
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RIERSLK 8
          R+ERS+K
Sbjct: 79 RLERSMK 85
>XP_005270508
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIERSLK 8
           R+ERS+K
Sbjct: 399 RLERSMK 405
>NP_001003795
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIERSLK 8
           R+E+SLK
Sbjct: 598 RVEKSLK 604
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.143    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 429,912
Number of extensions: 764
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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