Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              20     390
NP_002935                                                              20     509
XP_006715611                                                           20     509
NP_001129157                                                           18    1935
NP_996844                                                              18    1935
XP_005254439                                                           18    1935
XP_006720568                                                           18    1935
XP_005254438                                                           18    1935
NP_002335                                                              18    1935
NP_444273                                                              17    4312
NP_055444                                                              16    5631
NP_060595                                                              16    5631
NP_001011722                                                           16    5631
XP_006725174                                                           16    5631
XP_006725173                                                           16    5631
XP_006725172                                                           16    5631
XP_006725171                                                           16    5631
XP_006725170                                                           16    5631
XP_006725169                                                           16    5631
XP_006725168                                                           16    5631
XP_006725167                                                           16    5631
XP_006716564                                                           16    5631
XP_005250826                                                           16    5631
XP_005266099                                                           16    5631
XP_006716304                                                           16    5631
XP_006716303                                                           16    5631
XP_006716302                                                           16    5631
XP_005266098                                                           16    5631
XP_005266097                                                           16    5631
XP_005266096                                                           16    5631
XP_006716301                                                           16    5631
XP_006710797                                                           16    5631
XP_005245986                                                           16    5631
XP_005245985                                                           16    5631
XP_005245984                                                           16    5631
XP_005245983                                                           16    5631
XP_006710796                                                           16    5631
XP_006710795                                                           16    5631
XP_005245982                                                           16    5631
XP_005245981                                                           16    5631
XP_006710794                                                           16    5631
XP_006710793                                                           16    5631
XP_006710792                                                           16    5631
XP_006710791                                                           16    5631
XP_006710790                                                           16    5631
XP_005245980                                                           16    5631
NP_001106                                                              16    5631
NP_005036                                                              16    7355
NP_774959                                                              16    7355
NP_848612                                                              16    7355
XP_006725381                                                           16    7355
XP_006725380                                                           16    7355
XP_005257295                                                           16    7355
XP_006721894                                                           16    7355
NP_001004700                                                           16    7355
NP_689957                                                              15    9605
NP_001926                                                              15    9605
NP_001120936                                                           15    9605
NP_056011                                                              15    9605
NP_001124479                                                           15    9605
NP_004403                                                              15    9605
XP_005252435                                                           15    9605
XP_005252433                                                           15    9605
XP_005252431                                                           15    9605
XP_005252430                                                           15    9605
XP_005252429                                                           15    9605
XP_006717451                                                           15    9605
XP_005262928                                                           15    9605
XP_005262927                                                           15    9605
XP_005262926                                                           15    9605
XP_005246428                                                           15    9605
>NP_004295
          Length = 1620

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    PQFILLELM 9
            P+FILLELM
Sbjct: 1191 PRFILLELM 1199
>NP_002935
          Length = 2347

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    PQFILLELM 9
            PQ+I+LELM
Sbjct: 2021 PQYIILELM 2029
>XP_006715611
          Length = 2342

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    PQFILLELM 9
            PQ+I+LELM
Sbjct: 2016 PQYIILELM 2024
>NP_001129157
          Length = 734

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PQFILLELM 9
           P+ ILLELM
Sbjct: 455 PRLILLELM 463
>NP_996844
          Length = 803

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PQFILLELM 9
           P+ ILLELM
Sbjct: 524 PRLILLELM 532
>XP_005254439
          Length = 475

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PQFILLELM 9
           P+ ILLELM
Sbjct: 196 PRLILLELM 204
>XP_006720568
          Length = 771

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PQFILLELM 9
           P+ ILLELM
Sbjct: 492 PRLILLELM 500
>XP_005254438
          Length = 819

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PQFILLELM 9
           P+ ILLELM
Sbjct: 540 PRLILLELM 548
>NP_002335
          Length = 864

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PQFILLELM 9
           P+ ILLELM
Sbjct: 585 PRLILLELM 593
>NP_444273
          Length = 136

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PQFILLELM 9
           P FILL+L+
Sbjct: 120 PLFILLQLL 128
>NP_055444
          Length = 1344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 543 PQFILL 548
>NP_060595
          Length = 1279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 463 PQFILL 468
>NP_001011722
          Length = 1240

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 424 PQFILL 429
>XP_006725174
          Length = 1306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 505 PQFILL 510
>XP_006725173
          Length = 1328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 568 PQFILL 573
>XP_006725172
          Length = 1329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 528 PQFILL 533
>XP_006725171
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 529 PQFILL 534
>XP_006725170
          Length = 1345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 544 PQFILL 549
>XP_006725169
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 567 PQFILL 572
>XP_006725168
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 567 PQFILL 572
>XP_006725167
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 568 PQFILL 573
>XP_006716564
          Length = 1185

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   PQFILLELM 9
           P+F++LE++
Sbjct: 379 PRFVVLEMI 387
>XP_005250826
          Length = 1221

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   PQFILLELM 9
           P+F++LE++
Sbjct: 379 PRFVVLEMI 387
>XP_005266099
          Length = 1306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 505 PQFILL 510
>XP_006716304
          Length = 1328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 568 PQFILL 573
>XP_006716303
          Length = 1329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 528 PQFILL 533
>XP_006716302
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 529 PQFILL 534
>XP_005266098
          Length = 1345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 544 PQFILL 549
>XP_005266097
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 567 PQFILL 572
>XP_005266096
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 567 PQFILL 572
>XP_006716301
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 568 PQFILL 573
>XP_006710797
          Length = 1040

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 229 PQFILL 234
>XP_005245986
          Length = 1052

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 241 PQFILL 246
>XP_005245985
          Length = 1054

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 238 PQFILL 243
>XP_005245984
          Length = 1057

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 241 PQFILL 246
>XP_005245983
          Length = 1235

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 424 PQFILL 429
>XP_006710796
          Length = 1236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 425 PQFILL 430
>XP_006710795
          Length = 1239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 428 PQFILL 433
>XP_005245982
          Length = 1240

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 424 PQFILL 429
>XP_005245981
          Length = 1241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 425 PQFILL 430
>XP_006710794
          Length = 1243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 427 PQFILL 432
>XP_006710793
          Length = 1243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 427 PQFILL 432
>XP_006710792
          Length = 1243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 427 PQFILL 432
>XP_006710791
          Length = 1244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 428 PQFILL 433
>XP_006710790
          Length = 1244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 428 PQFILL 433
>XP_005245980
          Length = 1244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PQFILL 6
           PQFILL
Sbjct: 428 PQFILL 433
>NP_001106
          Length = 1251

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   PQFILLELM 9
           P+F++LE++
Sbjct: 379 PRFVVLEMI 387
>NP_005036
          Length = 3460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PQFILLEL 8
            P+F+ LEL
Sbjct: 1179 PRFVYLEL 1186
>NP_774959
          Length = 3458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PQFILLEL 8
            P+F+ LEL
Sbjct: 1179 PRFVYLEL 1186
>NP_848612
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  FILLELM 9
          FILLEL+
Sbjct: 78 FILLELL 84
>XP_006725381
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  FILLELM 9
          FILLEL+
Sbjct: 78 FILLELL 84
>XP_006725380
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  FILLELM 9
          FILLEL+
Sbjct: 78 FILLELL 84
>XP_005257295
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  FILLELM 9
          FILLEL+
Sbjct: 78 FILLELL 84
>XP_006721894
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  FILLELM 9
          FILLEL+
Sbjct: 78 FILLELL 84
>NP_001004700
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PQFILLEL 8
          P+FILL L
Sbjct: 8  PEFILLGL 15
>NP_689957
          Length = 2213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PQFILLE 7
           P+F+LLE
Sbjct: 528 PRFMLLE 534
>NP_001926
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QFILLE 7
           QFILLE
Sbjct: 112 QFILLE 117
>NP_001120936
          Length = 3925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    PQFILLE 7
            P F+LLE
Sbjct: 1471 PSFLLLE 1477
>NP_056011
          Length = 1609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QFILLELM 9
           Q+IL+E M
Sbjct: 894 QYILMEFM 901
>NP_001124479
          Length = 1610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QFILLELM 9
           Q+IL+E M
Sbjct: 895 QYILMEFM 902
>NP_004403
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PQFILLE 7
           P++ILLE
Sbjct: 113 PKYILLE 119
>XP_005252435
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PQFILLE 7
          P++ILLE
Sbjct: 42 PKYILLE 48
>XP_005252433
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PQFILLE 7
          P++ILLE
Sbjct: 42 PKYILLE 48
>XP_005252431
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PQFILLE 7
           P++ILLE
Sbjct: 113 PKYILLE 119
>XP_005252430
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PQFILLE 7
           P++ILLE
Sbjct: 113 PKYILLE 119
>XP_005252429
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PQFILLE 7
           P++ILLE
Sbjct: 113 PKYILLE 119
>XP_006717451
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PQFILLE 7
           P++ILLE
Sbjct: 113 PKYILLE 119
>XP_005262928
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QFILLELM 9
           Q+IL+E M
Sbjct: 250 QYILMEFM 257
>XP_005262927
          Length = 1526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QFILLELM 9
           Q+IL+E M
Sbjct: 811 QYILMEFM 818
>XP_005262926
          Length = 1609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QFILLELM 9
           Q+IL+E M
Sbjct: 895 QYILMEFM 902
>XP_005246428
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QFILLE 7
           QFILLE
Sbjct: 111 QFILLE 116
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.159    0.454 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 468,346
Number of extensions: 774
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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