Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           20     299
NP_858045                                                              20     299
NP_006525                                                              20     299
NP_001167559                                                           20     299
NP_653253                                                              17    4312
NP_001186588                                                           17    4312
NP_001277251                                                           17    4312
NP_005500                                                              17    4312
NP_001277250                                                           17    4312
NP_001273716                                                           17    4312
NP_001186589                                                           17    4312
NP_001273748                                                           17    4312
XP_006716354                                                           17    4312
XP_006716353                                                           17    4312
XP_005273464                                                           17    4312
XP_006714623                                                           17    4312
XP_005271970                                                           17    4312
XP_005271969                                                           17    4312
XP_005271967                                                           17    4312
XP_005271966                                                           17    4312
XP_005246128                                                           17    4312
NP_001476                                                              17    4312
NP_001229468                                                           16    5631
NP_054790                                                              16    5631
XP_006723818                                                           16    5631
XP_006723817                                                           16    5631
XP_006723816                                                           16    5631
XP_006723815                                                           16    5631
XP_006723814                                                           16    5631
XP_006723813                                                           16    5631
XP_005260405                                                           16    5631
NP_787071                                                              16    7355
NP_001185928                                                           16    7355
NP_705871                                                              16    7355
NP_055279                                                              16    7355
NP_705870                                                              16    7355
NP_705869                                                              16    7355
NP_065909                                                              16    7355
XP_005254747                                                           16    7355
XP_005254746                                                           16    7355
XP_005254745                                                           16    7355
XP_005254744                                                           16    7355
XP_005254743                                                           16    7355
XP_005254742                                                           16    7355
XP_006715127                                                           16    7355
XP_006715126                                                           16    7355
XP_006715125                                                           16    7355
XP_006715124                                                           16    7355
XP_005245089                                                           16    7355
XP_006711303                                                           16    7355
XP_005245088                                                           16    7355
NP_056018                                                              16    7355
NP_001001563                                                           16    7355
NP_000273                                                              15    9605
NP_001171475                                                           15    9605
NP_001121164                                                           15    9605
NP_073746                                                              15    9605
NP_061122                                                              15    9605
NP_060745                                                              15    9605
NP_001138696                                                           15    9605
NP_001157876                                                           15    9605
XP_006723397                                                           15    9605
XP_005259220                                                           15    9605
XP_006723396                                                           15    9605
XP_006723395                                                           15    9605
XP_006723394                                                           15    9605
XP_006723393                                                           15    9605
XP_006723392                                                           15    9605
XP_006720716                                                           15    9605
XP_006720715                                                           15    9605
XP_006720668                                                           15    9605
XP_006720667                                                           15    9605
XP_005254116                                                           15    9605
NP_001033729                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PPNAMMLSR 9
            PPNAMM SR
Sbjct: 1330 PPNAMMSSR 1338
>NP_858045
          Length = 1424

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PPNAMMLSR 9
            PPNAMM SR
Sbjct: 1331 PPNAMMSSR 1339
>NP_006525
          Length = 1420

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PPNAMMLSR 9
            PPNAMM SR
Sbjct: 1327 PPNAMMSSR 1335
>NP_001167559
          Length = 1415

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PPNAMMLSR 9
            PPNAMM SR
Sbjct: 1322 PPNAMMSSR 1330
>NP_653253
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PPNAMMLSR 9
           PP+ ++LSR
Sbjct: 284 PPSLLLLSR 292
>NP_001186588
          Length = 444

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PPNAMMLSR 9
           PP+ ++LSR
Sbjct: 332 PPSLLLLSR 340
>NP_001277251
          Length = 2854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN MM+S+
Sbjct: 422 PNVMMISK 429
>NP_005500
          Length = 3027

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>NP_001277250
          Length = 3048

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>NP_001273716
          Length = 288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PPNAMMLSR 9
           PP+ ++LSR
Sbjct: 176 PPSLLLLSR 184
>NP_001186589
          Length = 288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PPNAMMLSR 9
           PP+ ++LSR
Sbjct: 176 PPSLLLLSR 184
>NP_001273748
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PPNAMMLSR 9
           PP+ ++LSR
Sbjct: 379 PPSLLLLSR 387
>XP_006716354
          Length = 288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PPNAMMLSR 9
           PP+ ++LSR
Sbjct: 176 PPSLLLLSR 184
>XP_006716353
          Length = 378

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PPNAMMLSR 9
           PP+ ++LSR
Sbjct: 266 PPSLLLLSR 274
>XP_005273464
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PPNAMMLSR 9
           PP+ ++LSR
Sbjct: 379 PPSLLLLSR 387
>XP_006714623
          Length = 1625

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>XP_005271970
          Length = 2931

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>XP_005271969
          Length = 3020

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN MM+S+
Sbjct: 529 PNVMMISK 536
>XP_005271967
          Length = 3065

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>XP_005271966
          Length = 3086

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>XP_005246128
          Length = 222

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PPNAMMLSR 9
          PP+ MM+ R
Sbjct: 6  PPSLMMMQR 14
>NP_001476
          Length = 348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PPNAMMLSR 9
          PP+ MM+ R
Sbjct: 6  PPSLMMMQR 14
>NP_001229468
          Length = 1070

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 644 PQNPMILSR 652
>NP_054790
          Length = 2063

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 644 PQNPMILSR 652
>XP_006723818
          Length = 1975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 644 PQNPMILSR 652
>XP_006723817
          Length = 2020

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 601 PQNPMILSR 609
>XP_006723816
          Length = 2034

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 644 PQNPMILSR 652
>XP_006723815
          Length = 2051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 632 PQNPMILSR 640
>XP_006723814
          Length = 2052

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 633 PQNPMILSR 641
>XP_006723813
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 644 PQNPMILSR 652
>XP_005260405
          Length = 2063

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PPNAMMLSR 9
           P N M+LSR
Sbjct: 644 PQNPMILSR 652
>NP_787071
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PPNAMMLS 8
           PP  +MLS
Sbjct: 651 PPEGLMLS 658
>NP_001185928
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 922 PNGVLLSR 929
>NP_705871
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 984 PNGVLLSR 991
>NP_055279
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PPNAMMLS 8
           PP+ M+LS
Sbjct: 196 PPSPMLLS 203
>NP_705870
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 928 PNGVLLSR 935
>NP_705869
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 909 PNGVLLSR 916
>NP_065909
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 922 PNGVLLSR 929
>XP_005254747
          Length = 1030

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 941 PNGVLLSR 948
>XP_005254746
          Length = 1054

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 965 PNGVLLSR 972
>XP_005254745
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 978 PNGVLLSR 985
>XP_005254744
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PNAMMLSR 9
           PN ++LSR
Sbjct: 984 PNGVLLSR 991
>XP_005254743
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PNAMMLSR 9
            PN ++LSR
Sbjct: 997  PNGVLLSR 1004
>XP_005254742
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PNAMMLSR 9
            PN ++LSR
Sbjct: 997  PNGVLLSR 1004
>XP_006715127
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PPNAMMLS 8
          PP+ M+LS
Sbjct: 15 PPSPMLLS 22
>XP_006715126
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PPNAMMLS 8
           PP+ M+LS
Sbjct: 199 PPSPMLLS 206
>XP_006715125
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PPNAMMLS 8
           PP+ M+LS
Sbjct: 178 PPSPMLLS 185
>XP_006715124
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PPNAMMLS 8
           PP+ M+LS
Sbjct: 199 PPSPMLLS 206
>XP_005245089
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PPNAMM 6
           PP+AMM
Sbjct: 816 PPSAMM 821
>XP_006711303
          Length = 960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PPNAMM 6
           PP+AMM
Sbjct: 842 PPSAMM 847
>XP_005245088
          Length = 1435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PPNAMM 6
           PP+AMM
Sbjct: 816 PPSAMM 821
>NP_056018
          Length = 1461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PPNAMM 6
           PP+AMM
Sbjct: 842 PPSAMM 847
>NP_001001563
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PPNAMMLSR 9
          PP+A  LSR
Sbjct: 60 PPDAFGLSR 68
>NP_000273
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  PPNAMMLS 8
          PP  +MLS
Sbjct: 21 PPQQLMLS 28
>NP_001171475
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  PPNAMMLS 8
          PP  +MLS
Sbjct: 21 PPQQLMLS 28
>NP_001121164
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  PPNAMMLS 8
          PP  +MLS
Sbjct: 21 PPQQLMLS 28
>NP_073746
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PNAMMLSR 9
            PNA  LSR
Sbjct: 1272 PNAAALSR 1279
>NP_061122
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PPNAMML 7
          PP+ MML
Sbjct: 8  PPHPMML 14
>NP_060745
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PPNAMMLSR 9
           PP A  LSR
Sbjct: 484 PPEARPLSR 492
>NP_001138696
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PPNAMML 7
          PP+ MML
Sbjct: 8  PPHPMML 14
>NP_001157876
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PPNAMML 7
          PP+ MML
Sbjct: 8  PPHPMML 14
>XP_006723397
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PNAMMLSR 9
            PNA  LSR
Sbjct: 1213 PNAAALSR 1220
>XP_005259220
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PNAMMLSR 9
            PNA  LSR
Sbjct: 1272 PNAAALSR 1279
>XP_006723396
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PNAMMLSR 9
            PNA  LSR
Sbjct: 1272 PNAAALSR 1279
>XP_006723395
          Length = 1387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PNAMMLSR 9
            PNA  LSR
Sbjct: 1273 PNAAALSR 1280
>XP_006723394
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PNAMMLSR 9
            PNA  LSR
Sbjct: 1292 PNAAALSR 1299
>XP_006723393
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PNAMMLSR 9
            PNA  LSR
Sbjct: 1292 PNAAALSR 1299
>XP_006723392
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PNAMMLSR 9
            PNA  LSR
Sbjct: 1292 PNAAALSR 1299
>XP_006720716
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PPNAMML 7
          PP+ MML
Sbjct: 8  PPHPMML 14
>XP_006720715
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PPNAMML 7
          PP+ MML
Sbjct: 8  PPHPMML 14
>XP_006720668
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PPNAMML 7
          PP+ MML
Sbjct: 8  PPHPMML 14
>XP_006720667
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PPNAMML 7
          PP+ MML
Sbjct: 8  PPHPMML 14
>XP_005254116
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  PPNAMMLS 8
          PP  +MLS
Sbjct: 21 PPQQLMLS 28
>NP_001033729
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PPNAMML 7
          PP+ MML
Sbjct: 8  PPHPMML 14
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.127    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 729,146
Number of extensions: 700
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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