Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           20     509
NP_858045                                                              20     509
NP_006525                                                              20     509
NP_001167559                                                           20     509
NP_001277251                                                           17    4312
NP_005500                                                              17    4312
NP_001277250                                                           17    4312
XP_006714623                                                           17    4312
XP_005271970                                                           17    4312
XP_005271969                                                           17    4312
XP_005271967                                                           17    4312
XP_005271966                                                           17    4312
NP_060119                                                              16    5631
NP_951058                                                              16    5631
NP_001185928                                                           16    7355
NP_705871                                                              16    7355
NP_001482                                                              16    7355
NP_705870                                                              16    7355
NP_705869                                                              16    7355
NP_065909                                                              16    7355
XP_005254747                                                           16    7355
XP_005254746                                                           16    7355
XP_005254745                                                           16    7355
XP_005254744                                                           16    7355
XP_005254743                                                           16    7355
XP_005254742                                                           16    7355
XP_006715118                                                           16    7355
XP_005249054                                                           16    7355
NP_073746                                                              15    9605
NP_079019                                                              15    9605
NP_066962                                                              15    9605
NP_001099147                                                           15    9605
XP_006725063                                                           15    9605
XP_006723397                                                           15    9605
XP_005259220                                                           15    9605
XP_006723396                                                           15    9605
XP_006723395                                                           15    9605
XP_006723394                                                           15    9605
XP_006723393                                                           15    9605
XP_006723392                                                           15    9605
XP_006714368                                                           15    9605
XP_005265758                                                           15    9605
NP_001239204                                                           15    9605
NP_001239203                                                           15    9605
NP_006789                                                              15    9605
>NP_001167558
          Length = 1423

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PNAMMLSRM 9
            PNAMM SRM
Sbjct: 1331 PNAMMSSRM 1339
>NP_858045
          Length = 1424

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PNAMMLSRM 9
            PNAMM SRM
Sbjct: 1332 PNAMMSSRM 1340
>NP_006525
          Length = 1420

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PNAMMLSRM 9
            PNAMM SRM
Sbjct: 1328 PNAMMSSRM 1336
>NP_001167559
          Length = 1415

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PNAMMLSRM 9
            PNAMM SRM
Sbjct: 1323 PNAMMSSRM 1331
>NP_001277251
          Length = 2854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN MM+S+
Sbjct: 422 PNVMMISK 429
>NP_005500
          Length = 3027

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>NP_001277250
          Length = 3048

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>XP_006714623
          Length = 1625

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>XP_005271970
          Length = 2931

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>XP_005271969
          Length = 3020

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN MM+S+
Sbjct: 529 PNVMMISK 536
>XP_005271967
          Length = 3065

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>XP_005271966
          Length = 3086

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN MM+S+
Sbjct: 595 PNVMMISK 602
>NP_060119
          Length = 875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NA+M SRM
Sbjct: 814 NALMASRM 821
>NP_951058
          Length = 853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NA+M SRM
Sbjct: 792 NALMASRM 799
>NP_001185928
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 922 PNGVLLSR 929
>NP_705871
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 984 PNGVLLSR 991
>NP_001482
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PNAMMLSRM 9
           PNA + S+M
Sbjct: 146 PNAFLASKM 154
>NP_705870
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 928 PNGVLLSR 935
>NP_705869
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 909 PNGVLLSR 916
>NP_065909
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 922 PNGVLLSR 929
>XP_005254747
          Length = 1030

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 941 PNGVLLSR 948
>XP_005254746
          Length = 1054

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 965 PNGVLLSR 972
>XP_005254745
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 978 PNGVLLSR 985
>XP_005254744
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PNAMMLSR 8
           PN ++LSR
Sbjct: 984 PNGVLLSR 991
>XP_005254743
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PNAMMLSR 8
            PN ++LSR
Sbjct: 997  PNGVLLSR 1004
>XP_005254742
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PNAMMLSR 8
            PN ++LSR
Sbjct: 997  PNGVLLSR 1004
>XP_006715118
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PNAMMLSRM 9
           PNA + S+M
Sbjct: 146 PNAFLASKM 154
>XP_005249054
          Length = 363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PNAMMLSRM 9
           PNA + S+M
Sbjct: 146 PNAFLASKM 154
>NP_073746
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PNAMMLSR 8
            PNA  LSR
Sbjct: 1272 PNAAALSR 1279
>NP_079019
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 439 NAMRLSRI 446
>NP_066962
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 441 NAMKLSRI 448
>NP_001099147
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 448 NAMRLSRI 455
>XP_006725063
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 201 NAMRLSRI 208
>XP_006723397
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PNAMMLSR 8
            PNA  LSR
Sbjct: 1213 PNAAALSR 1220
>XP_005259220
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PNAMMLSR 8
            PNA  LSR
Sbjct: 1272 PNAAALSR 1279
>XP_006723396
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PNAMMLSR 8
            PNA  LSR
Sbjct: 1272 PNAAALSR 1279
>XP_006723395
          Length = 1387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PNAMMLSR 8
            PNA  LSR
Sbjct: 1273 PNAAALSR 1280
>XP_006723394
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PNAMMLSR 8
            PNA  LSR
Sbjct: 1292 PNAAALSR 1299
>XP_006723393
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PNAMMLSR 8
            PNA  LSR
Sbjct: 1292 PNAAALSR 1299
>XP_006723392
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PNAMMLSR 8
            PNA  LSR
Sbjct: 1292 PNAAALSR 1299
>XP_006714368
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 201 NAMRLSRI 208
>XP_005265758
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 215 NAMKLSRI 222
>NP_001239204
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 439 NAMRLSRI 446
>NP_001239203
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 605 NAMRLSRI 612
>NP_006789
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NAMMLSRM 9
           NAM LSR+
Sbjct: 439 NAMRLSRI 446
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.124    0.348 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 346,358
Number of extensions: 433
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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