Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              19     665
NP_996844                                                              19     869
XP_005254439                                                           19     869
XP_006720568                                                           19     869
XP_005254438                                                           19     869
NP_002335                                                              19     869
NP_001128668                                                           17    4312
XP_006723058                                                           17    4312
XP_006717666                                                           17    4312
XP_005269535                                                           17    4312
XP_006717665                                                           17    4312
XP_005269533                                                           17    4312
XP_005269534                                                           17    4312
NP_001073903                                                           17    4312
NP_000370                                                              16    5631
NP_000072                                                              16    7355
NP_005237                                                              16    7355
NP_056537                                                              16    7355
NP_001231873                                                           16    7355
NP_001231875                                                           16    7355
NP_055898                                                              16    7355
NP_057591                                                              16    7355
NP_473364                                                              16    7355
NP_694544                                                              16    7355
NP_001231874                                                           16    7355
XP_005257515                                                           16    7355
XP_005257513                                                           16    7355
XP_005252742                                                           16    7355
XP_006715985                                                           16    7355
XP_006715984                                                           16    7355
XP_005271980                                                           16    7355
XP_006714636                                                           16    7355
XP_006714635                                                           16    7355
XP_005273087                                                           16    7355
XP_005273086                                                           16    7355
XP_005273085                                                           16    7355
XP_005273084                                                           16    7355
NP_001035755                                                           16    7355
NP_001035756                                                           16    7355
NP_065883                                                              15    9605
XP_005245423                                                           15    9605
XP_005245425                                                           15    9605
NP_055714                                                              15    9605
>NP_004295
          Length = 1620

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PLQVVVKTL 9
            PLQV VKTL
Sbjct: 1144 PLQVAVKTL 1152
>NP_996844
          Length = 803

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           PLQV +KTL
Sbjct: 477 PLQVAIKTL 485
>XP_005254439
          Length = 475

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           PLQV +KTL
Sbjct: 149 PLQVAIKTL 157
>XP_006720568
          Length = 771

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           PLQV +KTL
Sbjct: 445 PLQVAIKTL 453
>XP_005254438
          Length = 819

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           PLQV +KTL
Sbjct: 493 PLQVAIKTL 501
>NP_002335
          Length = 864

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           PLQV +KTL
Sbjct: 538 PLQVAIKTL 546
>NP_001128668
          Length = 1435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PLQVVVKT 8
            PLQV +KT
Sbjct: 1291 PLQVKIKT 1298
>XP_006723058
          Length = 1460

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   PLQVVVKTL 9
           P QVVVK L
Sbjct: 158 PAQVVVKEL 166
>XP_006717666
          Length = 1289

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PLQVVVKT 8
            PLQV +KT
Sbjct: 1145 PLQVKIKT 1152
>XP_005269535
          Length = 1435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PLQVVVKT 8
            PLQV +KT
Sbjct: 1291 PLQVKIKT 1298
>XP_006717665
          Length = 1435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PLQVVVKT 8
            PLQV +KT
Sbjct: 1291 PLQVKIKT 1298
>XP_005269533
          Length = 1435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PLQVVVKT 8
            PLQV +KT
Sbjct: 1291 PLQVKIKT 1298
>XP_005269534
          Length = 1435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PLQVVVKT 8
            PLQV +KT
Sbjct: 1291 PLQVKIKT 1298
>NP_001073903
          Length = 1489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   PLQVVVKTL 9
           P QVVVK L
Sbjct: 187 PAQVVVKEL 195
>NP_000370
          Length = 1333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLQVVVKTL 9
           PL +V KTL
Sbjct: 304 PLSIVEKTL 312
>NP_000072
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LQVVVKTL 9
           LQ+ VKTL
Sbjct: 774 LQIYVKTL 781
>NP_005237
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LQVVVKTL 9
           LQV++KTL
Sbjct: 305 LQVMLKTL 312
>NP_056537
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PLQVVVKT 8
          P QVV+KT
Sbjct: 43 PDQVVIKT 50
>NP_001231873
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           P+++V KTL
Sbjct: 251 PIEIVNKTL 259
>NP_001231875
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           P+++V KTL
Sbjct: 251 PIEIVNKTL 259
>NP_055898
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLQVVVKT 8
           P+QV VKT
Sbjct: 604 PVQVSVKT 611
>NP_057591
          Length = 1490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLQVVVKT 8
           P+QV VKT
Sbjct: 604 PVQVSVKT 611
>NP_473364
          Length = 93

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  PLQVVVKTL 9
          PL++++KTL
Sbjct: 48 PLKLLLKTL 56
>NP_694544
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           P+++V KTL
Sbjct: 251 PIEIVNKTL 259
>NP_001231874
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           P+++V KTL
Sbjct: 251 PIEIVNKTL 259
>XP_005257515
          Length = 1256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLQVVVKT 8
           P+QV VKT
Sbjct: 604 PVQVSVKT 611
>XP_005257513
          Length = 1489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLQVVVKT 8
           P+QV VKT
Sbjct: 603 PVQVSVKT 610
>XP_005252742
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PLQVVVKT 8
          P QVV+KT
Sbjct: 43 PDQVVIKT 50
>XP_006715985
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           P+++V KTL
Sbjct: 251 PIEIVNKTL 259
>XP_006715984
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           P+++V KTL
Sbjct: 251 PIEIVNKTL 259
>XP_005271980
          Length = 749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LQVVVKTL 9
           LQV++KTL
Sbjct: 232 LQVMLKTL 239
>XP_006714636
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LQVVVKTL 9
           LQV++KTL
Sbjct: 305 LQVMLKTL 312
>XP_006714635
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LQVVVKTL 9
           LQV++KTL
Sbjct: 305 LQVMLKTL 312
>XP_005273087
          Length = 2788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LQVVVKTL 9
           LQ+ VKTL
Sbjct: 774 LQIYVKTL 781
>XP_005273086
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LQVVVKTL 9
           LQ+ VKTL
Sbjct: 774 LQIYVKTL 781
>XP_005273085
          Length = 3755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LQVVVKTL 9
           LQ+ VKTL
Sbjct: 774 LQIYVKTL 781
>XP_005273084
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LQVVVKTL 9
           LQ+ VKTL
Sbjct: 774 LQIYVKTL 781
>NP_001035755
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           P+++V KTL
Sbjct: 251 PIEIVNKTL 259
>NP_001035756
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           P+++V KTL
Sbjct: 251 PIEIVNKTL 259
>NP_065883
          Length = 1237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           PL+V +KT+
Sbjct: 327 PLKVRIKTI 335
>XP_005245423
          Length = 1246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           PL+V +KT+
Sbjct: 336 PLKVRIKTI 344
>XP_005245425
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLQVVVKTL 9
           PL+V +KT+
Sbjct: 389 PLKVRIKTI 397
>NP_055714
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PLQVVVK 7
           PL+V+VK
Sbjct: 326 PLRVIVK 332
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.140    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 362,332
Number of extensions: 535
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package