Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_078966                                                              17    4312
NP_054893                                                              17    4312
NP_001032382                                                           17    4312
NP_954995                                                              17    4312
XP_006723004                                                           17    4312
XP_005271584                                                           17    4312
NP_116250                                                              16    5631
NP_005645                                                              16    5631
NP_066285                                                              16    5631
NP_060521                                                              16    5631
NP_001138627                                                           16    5631
NP_001138628                                                           16    5631
NP_001138629                                                           16    5631
XP_006726470                                                           16    5631
XP_005249607                                                           16    5631
XP_005249606                                                           16    5631
XP_006716104                                                           16    5631
XP_006715649                                                           16    5631
XP_006715648                                                           16    5631
XP_006713517                                                           16    5631
XP_006710213                                                           16    5631
NP_001001956                                                           16    5631
NP_689957                                                              16    7355
NP_001258463                                                           16    7355
NP_001380                                                              16    7355
NP_055914                                                              16    7355
NP_001273428                                                           16    7355
NP_001273425                                                           16    7355
NP_079325                                                              16    7355
NP_001164639                                                           16    7355
NP_001164638                                                           16    7355
NP_110429                                                              16    7355
NP_001273426                                                           16    7355
XP_006724038                                                           16    7355
XP_006721545                                                           16    7355
XP_006721544                                                           16    7355
XP_006721543                                                           16    7355
XP_006721542                                                           16    7355
XP_006721541                                                           16    7355
NP_001164637                                                           16    7355
NP_001026851                                                           15    9605
NP_004928                                                              15    9605
NP_776188                                                              15    9605
NP_149972                                                              15    9605
NP_001191675                                                           15    9605
NP_001191674                                                           15    9605
NP_001191673                                                           15    9605
NP_004053                                                              15    9605
XP_006721526                                                           15    9605
XP_005256542                                                           15    9605
XP_005255827                                                           15    9605
XP_005255826                                                           15    9605
XP_005255825                                                           15    9605
XP_005265737                                                           15    9605
XP_005265736                                                           15    9605
NP_060644                                                              15    9605
>NP_078966
          Length = 14507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PLKATILFT 9
            PL+ T LFT
Sbjct: 8880 PLRVTSLFT 8888
>NP_054893
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLKATILFT 9
           PLK  +LFT
Sbjct: 191 PLKNMVLFT 199
>NP_001032382
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLKATILFT 9
           PLK  +LFT
Sbjct: 191 PLKNMVLFT 199
>NP_954995
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLKATILFT 9
           PLK  +LFT
Sbjct: 191 PLKNMVLFT 199
>XP_006723004
          Length = 6443

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLKATILFT 9
           PL+ T LFT
Sbjct: 794 PLRVTSLFT 802
>XP_005271584
          Length = 266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLKATILFT 9
           PLK  +LFT
Sbjct: 232 PLKNMVLFT 240
>NP_116250
          Length = 654

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           P+KA +LF
Sbjct: 391 PIKADVLF 398
>NP_005645
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKATILFT 9
           LKA +LFT
Sbjct: 322 LKAIVLFT 329
>NP_066285
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKATILFT 9
           LKA +LFT
Sbjct: 315 LKAIVLFT 322
>NP_060521
          Length = 1066

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PLKA +LF
Sbjct: 706 PLKAFLLF 713
>NP_001138627
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKATILFT 9
           LKA +LFT
Sbjct: 182 LKAIVLFT 189
>NP_001138628
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKATILFT 9
           LKA +LFT
Sbjct: 162 LKAIVLFT 169
>NP_001138629
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKATILFT 9
           LKA +LFT
Sbjct: 162 LKAIVLFT 169
>XP_006726470
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLKATILFT 9
           PLK+ ++FT
Sbjct: 143 PLKSKMIFT 151
>XP_005249607
          Length = 579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PLKA +LF
Sbjct: 219 PLKAFLLF 226
>XP_005249606
          Length = 878

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PLKA +LF
Sbjct: 518 PLKAFLLF 525
>XP_006716104
          Length = 1069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PLKA +LF
Sbjct: 709 PLKAFLLF 716
>XP_006715649
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           P+KA +LF
Sbjct: 321 PIKADVLF 328
>XP_006715648
          Length = 616

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           P+KA +LF
Sbjct: 353 PIKADVLF 360
>XP_006713517
          Length = 178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLKATILFT 9
           PLK+ ++FT
Sbjct: 130 PLKSKMIFT 138
>XP_006710213
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLKATILFT 9
           PLK+ ++FT
Sbjct: 143 PLKSKMIFT 151
>NP_001001956
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKATILFT 9
           L ATILFT
Sbjct: 200 LVATILFT 207
>NP_689957
          Length = 2213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    PLKATILFT 9
            PL+AT++ T
Sbjct: 1463 PLEATVITT 1471
>NP_001258463
          Length = 1994

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKATI
Sbjct: 313 PLKATI 318
>NP_001380
          Length = 2012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKATI
Sbjct: 313 PLKATI 318
>NP_055914
          Length = 1202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 605 PLSASVLF 612
>NP_001273428
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLKATILFT 9
          PL+A  LFT
Sbjct: 17 PLRAARLFT 25
>NP_001273425
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLKATILFT 9
          PL+A  LFT
Sbjct: 70 PLRAARLFT 78
>NP_079325
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLKATILFT 9
          PL+A  LFT
Sbjct: 70 PLRAARLFT 78
>NP_001164639
          Length = 1201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 604 PLSASVLF 611
>NP_001164638
          Length = 1241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 628 PLSASVLF 635
>NP_110429
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PLKATILF 8
          PL+ATI F
Sbjct: 43 PLRATIPF 50
>NP_001273426
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLKATILFT 9
          PL+A  LFT
Sbjct: 70 PLRAARLFT 78
>XP_006724038
          Length = 1907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKATI
Sbjct: 208 PLKATI 213
>XP_006721545
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 418 PLSASVLF 425
>XP_006721544
          Length = 1178

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 581 PLSASVLF 588
>XP_006721543
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 605 PLSASVLF 612
>XP_006721542
          Length = 1200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 610 PLSASVLF 617
>XP_006721541
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 610 PLSASVLF 617
>NP_001164637
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLKATILF 8
           PL A++LF
Sbjct: 607 PLSASVLF 614
>NP_001026851
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PLKATILFT 9
          PL AT++ T
Sbjct: 49 PLNATLVIT 57
>NP_004928
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PLKATILFT 9
          PL AT++ T
Sbjct: 49 PLNATLVIT 57
>NP_776188
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLKATIL 7
           P KAT+L
Sbjct: 167 PFKATVL 173
>NP_149972
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PLKATILFT 9
          PL  T LFT
Sbjct: 37 PLNGTWLFT 45
>NP_001191675
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKAT+
Sbjct: 727 PLKATV 732
>NP_001191674
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKAT+
Sbjct: 785 PLKATV 790
>NP_001191673
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKAT+
Sbjct: 802 PLKATV 807
>NP_004053
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKAT+
Sbjct: 824 PLKATV 829
>XP_006721526
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PLKATILFT 9
          PL AT++ T
Sbjct: 49 PLNATLVIT 57
>XP_005256542
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  PLKATILFT 9
          PL AT++ T
Sbjct: 49 PLNATLVIT 57
>XP_005255827
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKAT+
Sbjct: 646 PLKATV 651
>XP_005255826
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKAT+
Sbjct: 761 PLKATV 766
>XP_005255825
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PLKATI 6
           PLKAT+
Sbjct: 824 PLKATV 829
>XP_005265737
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLKATIL 7
           P KAT+L
Sbjct: 167 PFKATVL 173
>XP_005265736
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLKATIL 7
           P KAT+L
Sbjct: 167 PFKATVL 173
>NP_060644
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PLKATILF 8
           P K T+LF
Sbjct: 378 PAKPTVLF 385
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.143    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 378,543
Number of extensions: 764
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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