Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_006718908                                                           20     299
XP_005271621                                                           20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_060656                                                              18    1135
XP_005245374                                                           18    1135
NP_001230655                                                           18    1935
NP_001230654                                                           18    1935
NP_001123356                                                           18    1935
NP_001265124                                                           18    1935
NP_057010                                                              18    1935
XP_006713261                                                           18    1935
XP_006713260                                                           18    1935
XP_006713259                                                           18    1935
XP_006713258                                                           18    1935
NP_037373                                                              17    2528
NP_001078                                                              17    2528
XP_006721243                                                           17    2528
XP_005255967                                                           17    2528
XP_005255966                                                           17    2528
XP_005246382                                                           17    2528
NP_055178                                                              17    3301
NP_060855                                                              17    3301
NP_001264984                                                           17    3301
NP_059830                                                              17    3301
XP_005266395                                                           17    3301
XP_006714051                                                           17    3301
NP_005103                                                              17    3301
NP_037522                                                              17    4312
NP_001129292                                                           17    4312
XP_006717096                                                           17    4312
XP_005251926                                                           17    4312
NP_000858                                                              16    5631
NP_005233                                                              16    7355
NP_055603                                                              16    7355
NP_150088                                                              16    7355
XP_006717402                                                           16    7355
XP_006717401                                                           16    7355
XP_005252380                                                           16    7355
XP_005252379                                                           16    7355
XP_005252378                                                           16    7355
XP_005252377                                                           16    7355
NP_002105                                                              15    9605
NP_001186732                                                           15    9605
NP_077298                                                              15    9605
NP_001136105                                                           15    9605
NP_055123                                                              15    9605
NP_036451                                                              15    9605
XP_005256637                                                           15    9605
XP_005256636                                                           15    9605
XP_005249099                                                           15    9605
XP_006714919                                                           15    9605
XP_006712165                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PLHVIKATF 9
            P HVIKATF
Sbjct: 1382 PSHVIKATF 1390
>XP_006718908
          Length = 1708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  PLHVIKATF 9
          P HVIKATF
Sbjct: 34 PSHVIKATF 42
>XP_005271621
          Length = 2708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PLHVIKATF 9
            P HVIKATF
Sbjct: 1034 PSHVIKATF 1042
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PLHVIKATF 9
            P HVIKATF
Sbjct: 1376 PSHVIKATF 1384
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PLHVIKATF 9
            P HVIKATF
Sbjct: 1382 PSHVIKATF 1390
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PLHVIKATF 9
            P HVIKATF
Sbjct: 1382 PSHVIKATF 1390
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PLHVIKATF 9
            P HVIKATF
Sbjct: 1382 PSHVIKATF 1390
>NP_060656
          Length = 853

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LHVIKATF 9
           LH+IK+TF
Sbjct: 93  LHIIKSTF 100
>XP_005245374
          Length = 911

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LHVIKATF 9
           LH+IK+TF
Sbjct: 151 LHIIKSTF 158
>NP_001230655
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P HV+ ATF
Sbjct: 128 PSHVVTATF 136
>NP_001230654
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P HV+ ATF
Sbjct: 128 PSHVVTATF 136
>NP_001123356
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P HV+ ATF
Sbjct: 128 PSHVVTATF 136
>NP_001265124
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P HV+ ATF
Sbjct: 128 PSHVVTATF 136
>NP_057010
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P HV+ ATF
Sbjct: 128 PSHVVTATF 136
>XP_006713261
          Length = 242

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLHVIKATF 9
          P HV+ ATF
Sbjct: 57 PSHVVTATF 65
>XP_006713260
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P HV+ ATF
Sbjct: 128 PSHVVTATF 136
>XP_006713259
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P HV+ ATF
Sbjct: 128 PSHVVTATF 136
>XP_006713258
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P HV+ ATF
Sbjct: 128 PSHVVTATF 136
>NP_037373
          Length = 1164

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLHVIKA 7
           P+HVIKA
Sbjct: 712 PVHVIKA 718
>NP_001078
          Length = 434

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLHVIKAT 8
           P+HV+K T
Sbjct: 249 PIHVLKGT 256
>XP_006721243
          Length = 695

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLHVIKA 7
           P+HVIKA
Sbjct: 243 PVHVIKA 249
>XP_005255967
          Length = 1154

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLHVIKA 7
           P+HVIKA
Sbjct: 738 PVHVIKA 744
>XP_005255966
          Length = 1190

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLHVIKA 7
           P+HVIKA
Sbjct: 738 PVHVIKA 744
>XP_005246382
          Length = 435

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLHVIKAT 8
           P+HV+K T
Sbjct: 250 PIHVLKGT 257
>NP_055178
          Length = 4579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PLHVIKAT 8
            P+HV+K T
Sbjct: 2948 PIHVVKDT 2955
>NP_060855
          Length = 658

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLHVIKATF 9
           P HV++AT+
Sbjct: 479 PRHVLEATY 487
>NP_001264984
          Length = 4432

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PLHVIKAT 8
            P+HV+K T
Sbjct: 2801 PIHVVKDT 2808
>NP_059830
          Length = 606

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PLHVIK 6
           PLHVIK
Sbjct: 312 PLHVIK 317
>XP_005266395
          Length = 4588

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PLHVIKAT 8
            P+HV+K T
Sbjct: 2957 PIHVVKDT 2964
>XP_006714051
          Length = 480

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PLHVIK 6
           PLHVIK
Sbjct: 186 PLHVIK 191
>NP_005103
          Length = 466

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PLHVIK 6
           PLHVIK
Sbjct: 172 PLHVIK 177
>NP_037522
          Length = 1383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PLHVIKATF 9
           P+H+ ++TF
Sbjct: 877 PIHLTRSTF 885
>NP_001129292
          Length = 1320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PLHVIKATF 9
           P+H+ ++TF
Sbjct: 814 PIHLTRSTF 822
>XP_006717096
          Length = 1217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PLHVIKATF 9
           P+H+ ++TF
Sbjct: 877 PIHLTRSTF 885
>XP_005251926
          Length = 1383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PLHVIKATF 9
           P+H+ ++TF
Sbjct: 877 PIHLTRSTF 885
>NP_000858
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  PLHVIKATF 9
          P H++++TF
Sbjct: 15 PEHILQSTF 23
>NP_005233
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLHVIKAT 8
           PL+V+K T
Sbjct: 208 PLYVVKQT 215
>NP_055603
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 414 LHTFRATF 421
>NP_150088
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 414 LHTFRATF 421
>XP_006717402
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 364 LHTFRATF 371
>XP_006717401
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 364 LHTFRATF 371
>XP_005252380
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 414 LHTFRATF 421
>XP_005252379
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 414 LHTFRATF 421
>XP_005252378
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 414 LHTFRATF 421
>XP_005252377
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 414 LHTFRATF 421
>NP_002105
          Length = 2718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PLHVIK 6
           P+H+IK
Sbjct: 515 PVHIIK 520
>NP_001186732
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           PLH + A+F
Sbjct: 273 PLHQVFASF 281
>NP_077298
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           PLH + A+F
Sbjct: 279 PLHQVFASF 287
>NP_001136105
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 198 LHAFQATF 205
>NP_055123
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 198 LHAFQATF 205
>NP_036451
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  PLHVIKA 7
          PLH +KA
Sbjct: 20 PLHELKA 26
>XP_005256637
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 198 LHAFQATF 205
>XP_005256636
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LHVIKATF 9
           LH  +ATF
Sbjct: 198 LHAFQATF 205
>XP_005249099
          Length = 2026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PLHVIK 6
           P+H+IK
Sbjct: 515 PVHIIK 520
>XP_006714919
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           P H+ KA+F
Sbjct: 345 PTHLPKASF 353
>XP_006712165
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PLHVIKATF 9
           PLH + A+F
Sbjct: 279 PLHQVFASF 287
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.145    0.458 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 530,467
Number of extensions: 986
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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