Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              20     299
XP_005268094                                                           20     299
NP_009051                                                              18    1935
NP_061966                                                              18    1935
NP_061951                                                              17    3301
NP_056276                                                              17    4312
XP_005258298                                                           17    4312
XP_006722500                                                           17    4312
XP_006722499                                                           17    4312
NP_006437                                                              16    5631
NP_006035                                                              16    5631
NP_056150                                                              16    5631
NP_005112                                                              16    5631
XP_005272625                                                           16    5631
XP_006724588                                                           16    5631
XP_005272623                                                           16    5631
XP_005272622                                                           16    5631
XP_005272621                                                           16    5631
XP_006719370                                                           16    5631
XP_006719369                                                           16    5631
XP_006719368                                                           16    5631
XP_006716440                                                           16    5631
NP_001001922                                                           16    7355
XP_005267162                                                           16    7355
XP_005267161                                                           16    7355
XP_005267159                                                           16    7355
NP_001159719                                                           15    9605
NP_068775                                                              15    9605
NP_786944                                                              15    9605
NP_062818                                                              15    9605
NP_001243355                                                           15    9605
NP_001497                                                              15    9605
NP_001009562                                                           15    9605
NP_065937                                                              15    9605
NP_066580                                                              15    9605
NP_940684                                                              15    9605
NP_689523                                                              15    9605
XP_005253535                                                           15    9605
XP_005253534                                                           15    9605
XP_005253531                                                           15    9605
XP_005271698                                                           15    9605
XP_005271696                                                           15    9605
XP_005271695                                                           15    9605
XP_005271694                                                           15    9605
XP_005271693                                                           15    9605
XP_005271690                                                           15    9605
XP_005271689                                                           15    9605
XP_005271688                                                           15    9605
XP_005271687                                                           15    9605
XP_005267003                                                           15    9605
XP_006715528                                                           15    9605
XP_005267002                                                           15    9605
XP_006714133                                                           15    9605
XP_005262753                                                           15    9605
XP_006714131                                                           15    9605
XP_005262752                                                           15    9605
XP_005262750                                                           15    9605
XP_006714130                                                           15    9605
XP_006714129                                                           15    9605
NP_602307                                                              15    9605
NP_071387                                                              15    9605
>NP_000360
          Length = 764

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PLALSYIVF 9
           PLAL+YIVF
Sbjct: 577 PLALAYIVF 585
>XP_005268094
          Length = 764

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PLALSYIVF 9
           PLAL+YIVF
Sbjct: 577 PLALAYIVF 585
>NP_009051
          Length = 534

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLALSYI
Sbjct: 217 PLALSYI 223
>NP_061966
          Length = 534

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLALSYI
Sbjct: 217 PLALSYI 223
>NP_061951
          Length = 534

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLALSY+
Sbjct: 217 PLALSYL 223
>NP_056276
          Length = 1311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLAL+YI
Sbjct: 589 PLALNYI 595
>XP_005258298
          Length = 1091

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLAL+YI
Sbjct: 369 PLALNYI 375
>XP_006722500
          Length = 1218

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLAL+YI
Sbjct: 589 PLALNYI 595
>XP_006722499
          Length = 1310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLAL+YI
Sbjct: 589 PLALNYI 595
>NP_006437
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PL LSYI
Sbjct: 190 PLGLSYI 196
>NP_006035
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    PLALSYI 7
            PL LSYI
Sbjct: 1171 PLVLSYI 1177
>NP_056150
          Length = 2210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PLALSYIV 8
            PLAL Y V
Sbjct: 2094 PLALGYFV 2101
>NP_005112
          Length = 2174

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PLALSYIV 8
            PLAL Y V
Sbjct: 2062 PLALGYFV 2069
>XP_005272625
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    PLALSYI 7
            PL LSYI
Sbjct: 1171 PLVLSYI 1177
>XP_006724588
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    PLALSYI 7
            PL LSYI
Sbjct: 1171 PLVLSYI 1177
>XP_005272623
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    PLALSYI 7
            PL LSYI
Sbjct: 1171 PLVLSYI 1177
>XP_005272622
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    PLALSYI 7
            PL LSYI
Sbjct: 1171 PLVLSYI 1177
>XP_005272621
          Length = 1261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    PLALSYI 7
            PL LSYI
Sbjct: 1217 PLVLSYI 1223
>XP_006719370
          Length = 2076

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PLALSYIV 8
            PLAL Y V
Sbjct: 1960 PLALGYFV 1967
>XP_006719369
          Length = 2200

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PLALSYIV 8
            PLAL Y V
Sbjct: 2084 PLALGYFV 2091
>XP_006719368
          Length = 2209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PLALSYIV 8
            PLAL Y V
Sbjct: 2093 PLALGYFV 2100
>XP_006716440
          Length = 171

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           A+SYI+F
Sbjct: 156 AMSYIIF 162
>NP_001001922
          Length = 324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  PLALSYIVF 9
          PL   YI+F
Sbjct: 38 PLCTMYIIF 46
>XP_005267162
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ALSYIVF 9
           ALSY VF
Sbjct: 380 ALSYFVF 386
>XP_005267161
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ALSYIVF 9
           ALSY VF
Sbjct: 380 ALSYFVF 386
>XP_005267159
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ALSYIVF 9
           ALSY VF
Sbjct: 572 ALSYFVF 578
>NP_001159719
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLA++Y+
Sbjct: 516 PLAITYV 522
>NP_068775
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLA++Y+
Sbjct: 516 PLAITYV 522
>NP_786944
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLA++Y+
Sbjct: 516 PLAITYV 522
>NP_062818
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PL +SYI
Sbjct: 190 PLGISYI 196
>NP_001243355
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PLA SY+
Sbjct: 314 PLAFSYL 320
>NP_001497
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLALSYIV 8
           P+A+ YIV
Sbjct: 96  PIAMYYIV 103
>NP_001009562
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PL +SYI
Sbjct: 143 PLGISYI 149
>NP_065937
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 917 ALSYLVY 923
>NP_066580
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PL +SYI
Sbjct: 177 PLGISYI 183
>NP_940684
          Length = 254

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PLALSYIV 8
          PLA +Y+V
Sbjct: 36 PLATAYLV 43
>NP_689523
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PLALSYIV 8
          P+AL Y+V
Sbjct: 39 PIALIYLV 46
>XP_005253535
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PL +SYI
Sbjct: 175 PLGISYI 181
>XP_005253534
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PL +SYI
Sbjct: 157 PLGISYI 163
>XP_005253531
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PL +SYI
Sbjct: 177 PLGISYI 183
>XP_005271698
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 760 ALSYLVY 766
>XP_005271696
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 885 ALSYLVY 891
>XP_005271695
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 886 ALSYLVY 892
>XP_005271694
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 918 ALSYLVY 924
>XP_005271693
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 920 ALSYLVY 926
>XP_005271690
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 958 ALSYLVY 964
>XP_005271689
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 977 ALSYLVY 983
>XP_005271688
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 979 ALSYLVY 985
>XP_005271687
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALSYIVF 9
           ALSY+V+
Sbjct: 980 ALSYLVY 986
>XP_005267003
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLA++Y+
Sbjct: 467 PLAITYV 473
>XP_006715528
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLA++Y+
Sbjct: 516 PLAITYV 522
>XP_005267002
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PLALSYI 7
           PLA++Y+
Sbjct: 516 PLAITYV 522
>XP_006714133
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PLA SY+
Sbjct: 294 PLAFSYL 300
>XP_005262753
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PLA SY+
Sbjct: 308 PLAFSYL 314
>XP_006714131
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PLA SY+
Sbjct: 319 PLAFSYL 325
>XP_005262752
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PLA SY+
Sbjct: 417 PLAFSYL 423
>XP_005262750
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PLA SY+
Sbjct: 423 PLAFSYL 429
>XP_006714130
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PLA SY+
Sbjct: 428 PLAFSYL 434
>XP_006714129
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PLA SY+
Sbjct: 428 PLAFSYL 434
>NP_602307
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALSYI 7
           PL +SYI
Sbjct: 177 PLGISYI 183
>NP_071387
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLALSYIVF 9
           P  LS+IVF
Sbjct: 576 PEPLSFIVF 584
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.154    0.461 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 420,393
Number of extensions: 684
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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