Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              19     869
NP_001087241                                                           19     869
XP_006714101                                                           19     869
XP_005265799                                                           19     869
XP_005265798                                                           19     869
XP_005265797                                                           19     869
NP_001091672                                                           18    1482
NP_001640                                                              17    4312
XP_005274557                                                           17    4312
XP_006715357                                                           17    4312
NP_612429                                                              16    5631
NP_060821                                                              16    5631
XP_005267356                                                           16    5631
XP_005269081                                                           16    5631
NP_001138432                                                           16    5631
NP_006428                                                              16    7355
NP_078880                                                              16    7355
NP_001139547                                                           16    7355
NP_001135918                                                           16    7355
NP_001269461                                                           16    7355
NP_056154                                                              16    7355
NP_001269460                                                           16    7355
NP_001139548                                                           16    7355
NP_065208                                                              16    7355
NP_061724                                                              16    7355
NP_852107                                                              16    7355
NP_114065                                                              16    7355
XP_006723822                                                           16    7355
XP_005273533                                                           16    7355
NP_065210                                                              16    7355
NP_065209                                                              16    7355
NP_000028                                                              16    7355
NP_653253                                                              15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001186588                                                           15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_001273716                                                           15    9605
NP_001186589                                                           15    9605
NP_001273748                                                           15    9605
XP_006716354                                                           15    9605
XP_006716353                                                           15    9605
XP_006716352                                                           15    9605
XP_005273464                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_000213
          Length = 976

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PKADIMIKS 9
           PKA IMIKS
Sbjct: 166 PKAGIMIKS 174
>NP_001087241
          Length = 972

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PKADIMIKS 9
           PKA IMIKS
Sbjct: 166 PKAGIMIKS 174
>XP_006714101
          Length = 526

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PKADIMIKS 9
           PKA IMIKS
Sbjct: 166 PKAGIMIKS 174
>XP_005265799
          Length = 973

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PKADIMIKS 9
           PKA IMIKS
Sbjct: 166 PKAGIMIKS 174
>XP_005265798
          Length = 976

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PKADIMIKS 9
           PKA IMIKS
Sbjct: 166 PKAGIMIKS 174
>XP_005265797
          Length = 977

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PKADIMIKS 9
           PKA IMIKS
Sbjct: 166 PKAGIMIKS 174
>NP_001091672
          Length = 733

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  PKADIMIKS 9
          P+ADI++KS
Sbjct: 4  PEADILLKS 12
>NP_001640
          Length = 1616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    PKADIMIK 8
            PKA+++IK
Sbjct: 1404 PKAELLIK 1411
>XP_005274557
          Length = 1615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    PKADIMIK 8
            PKA+++IK
Sbjct: 1404 PKAELLIK 1411
>XP_006715357
          Length = 268

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  PKADIMIK 8
          PKAD++++
Sbjct: 34 PKADVLVE 41
>NP_612429
          Length = 5795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    PKADIM 6
            PKAD+M
Sbjct: 4248 PKADVM 4253
>NP_060821
          Length = 1430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PKADIMIKS 9
          PK DI+I S
Sbjct: 32 PKPDIVISS 40
>XP_005267356
          Length = 5695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    PKADIM 6
            PKAD+M
Sbjct: 4148 PKADVM 4153
>XP_005269081
          Length = 1389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PKADIMIKS 9
          PK DI+I S
Sbjct: 32 PKPDIVISS 40
>NP_001138432
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PKADIMIKS 9
           P AD ++KS
Sbjct: 469 PSADFLLKS 477
>NP_006428
          Length = 1724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PKA ++IK
Sbjct: 723 PKAKVLIK 730
>NP_078880
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KADIMIKS 9
           +ADI+IKS
Sbjct: 258 EADIVIKS 265
>NP_001139547
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KADIMIKS 9
           +ADI+IKS
Sbjct: 258 EADIVIKS 265
>NP_001135918
          Length = 1897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           P AD++IK
Sbjct: 715 PVADVLIK 722
>NP_001269461
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KADIMIKS 9
           KADI +KS
Sbjct: 600 KADIPVKS 607
>NP_056154
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KADIMIKS 9
           KADI +KS
Sbjct: 600 KADIPVKS 607
>NP_001269460
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KADIMIKS 9
           KADI +KS
Sbjct: 600 KADIPVKS 607
>NP_001139548
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KADIMIKS 9
           +ADI+IKS
Sbjct: 99  EADIVIKS 106
>NP_065208
          Length = 1856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           P AD++IK
Sbjct: 682 PVADVLIK 689
>NP_061724
          Length = 948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PKADIM 6
           PKAD+M
Sbjct: 763 PKADLM 768
>NP_852107
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KADIMIKS 9
           KADI +KS
Sbjct: 600 KADIPVKS 607
>NP_114065
          Length = 844

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PKADIM 6
           PKAD+M
Sbjct: 763 PKADLM 768
>XP_006723822
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KADIMIKS 9
           KADI +KS
Sbjct: 609 KADIPVKS 616
>XP_005273533
          Length = 1921

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           P AD++IK
Sbjct: 715 PVADVLIK 722
>NP_065210
          Length = 1719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           P AD++IK
Sbjct: 682 PVADVLIK 689
>NP_065209
          Length = 1881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           P AD++IK
Sbjct: 682 PVADVLIK 689
>NP_000028
          Length = 1880

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           P AD++IK
Sbjct: 682 PVADVLIK 689
>NP_653253
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 313 PKTDILVE 320
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    PKADIMIKS 9
            PK ++++KS
Sbjct: 4446 PKEEVVLKS 4454
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    PKADIMIKS 9
            PK ++++KS
Sbjct: 4571 PKEEVVLKS 4579
>NP_001186588
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 361 PKTDILVE 368
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1     PKADIMIKS 9
             PK ++++KS
Sbjct: 11870 PKEEVVLKS 11878
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1     PKADIMIKS 9
             PK ++++KS
Sbjct: 10943 PKEEVVLKS 10951
>NP_001273716
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 205 PKTDILVE 212
>NP_001186589
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 205 PKTDILVE 212
>NP_001273748
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 408 PKTDILVE 415
>XP_006716354
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 205 PKTDILVE 212
>XP_006716353
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 295 PKTDILVE 302
>XP_006716352
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 370 PKTDILVE 377
>XP_005273464
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PKADIMIK 8
           PK DI+++
Sbjct: 408 PKTDILVE 415
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PKADIMIKS 9
           PK ++++KS
Sbjct: 183 PKEEVVLKS 191
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    PKADIMIKS 9
            PK ++++KS
Sbjct: 1542 PKEEVVLKS 1550
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1     PKADIMIKS 9
             PK ++++KS
Sbjct: 11498 PKEEVVLKS 11506
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1     PKADIMIKS 9
             PK ++++KS
Sbjct: 13004 PKEEVVLKS 13012
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1     PKADIMIKS 9
             PK ++++KS
Sbjct: 13511 PKEEVVLKS 13519
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    PKADIMIKS 9
            PK ++++KS
Sbjct: 4638 PKEEVVLKS 4646
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.130    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 429,097
Number of extensions: 747
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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