Blast-Search of mutated query peptide against human proteome |
BLASTP 2.2.15 [Oct-15-2006] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= User_input (9 letters) Database: HUMAN_PROTEOME_FASTA 71,491 sequences; 45,948,801 total letters Searching..................................................doneScore E Sequences producing significant alignments: (bits) Value NP_722576 20 299 XP_005262424 20 299 XP_006715417 17 2528 NP_001029031 17 3301 NP_001257377 17 3301 NP_000009 17 3301 NP_001243556 17 3301 NP_001257376 17 3301 XP_006721579 17 3301 XP_005268733 17 3301 XP_005268732 17 3301 XP_005253277 17 3301 XP_006718442 17 3301 XP_006718440 17 3301 XP_006718439 17 3301 XP_006718437 17 3301 NP_006032 17 4312 NP_002214 17 4312 XP_005261469 17 4312 XP_006719127 17 4312 NP_055107 17 4312 NP_005453 16 5631 XP_003846820 16 5631 NP_001138596 16 5631 NP_114478 16 5631 NP_001128302 16 7355 NP_060121 16 7355 NP_001128303 16 7355 NP_001128304 16 7355 NP_000349 16 7355 NP_001185924 16 7355 NP_001185923 16 7355 NP_075394 16 7355 NP_001185922 16 7355 NP_073622 16 7355 NP_149095 16 7355 NP_001243359 16 7355 NP_075068 16 7355 XP_006724360 16 7355 XP_006724359 16 7355 XP_005261762 16 7355 XP_005261761 16 7355 XP_006720344 16 7355 XP_006720343 16 7355 XP_006720342 16 7355 XP_005267096 16 7355 XP_006715570 16 7355 XP_006710902 16 7355 XP_006710901 16 7355 XP_006710900 16 7355 XP_005244835 16 7355 NP_942153 16 7355 NP_001121084 15 9605 NP_000271 15 9605 NP_079437 15 9605 NP_001245394 15 9605 NP_005236 15 9605 NP_001245393 15 9605 NP_001245391 15 9605 NP_001245392 15 9605 NP_001595 15 9605 NP_008957 15 9605 NP_054730 15 9605 NP_653327 15 9605 NP_001186312 15 9605 NP_001186311 15 9605 NP_001186310 15 9605 NP_001186309 15 9605 XP_006725363 15 9605 XP_006722175 15 9605 XP_005257034 15 9605 XP_005253015 15 9605 XP_006718309 15 9605 XP_006718308 15 9605 XP_006718307 15 9605 XP_005253014 15 9605 XP_005253013 15 9605 XP_005253012 15 9605 XP_005253011 15 9605 XP_005265883 15 9605 XP_006714202 15 9605 XP_005262892 15 9605 XP_005262891 15 9605 NP_659198 15 9605>NP_722576 Length = 3080 Score = 20.4 bits (41), Expect = 299 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 1 PISSFFET 8 PISSFFET Sbjct: 2211 PISSFFET 2218>XP_005262424 Length = 2875 Score = 20.4 bits (41), Expect = 299 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 1 PISSFFET 8 PISSFFET Sbjct: 2006 PISSFFET 2013>XP_006715417 Length = 352 Score = 17.3 bits (33), Expect = 2528 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S FF+T+ Sbjct: 274 PLSLFFDTV 282>NP_001029031 Length = 633 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 P+S FFE + Sbjct: 86 PVSRFFEEV 94>NP_001257377 Length = 579 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 P+S FFE + Sbjct: 32 PVSRFFEEV 40>NP_000009 Length = 655 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 P+S FFE + Sbjct: 108 PVSRFFEEV 116>NP_001243556 Length = 736 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S+FF+ I Sbjct: 665 PLSNFFDVI 673>NP_001257376 Length = 678 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 P+S FFE + Sbjct: 131 PVSRFFEEV 139>XP_006721579 Length = 708 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 P+S FFE + Sbjct: 154 PVSRFFEEV 162>XP_005268733 Length = 487 Score = 16.9 bits (32), Expect = 3301 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 P SSFFE + Sbjct: 178 PSSSFFEAL 186>XP_005268732 Length = 550 Score = 16.9 bits (32), Expect = 3301 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 P SSFFE + Sbjct: 241 PSSSFFEAL 249>XP_005253277 Length = 453 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S+FF+ I Sbjct: 382 PLSNFFDVI 390>XP_006718442 Length = 675 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S+FF+ I Sbjct: 604 PLSNFFDVI 612>XP_006718440 Length = 698 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S+FF+ I Sbjct: 627 PLSNFFDVI 635>XP_006718439 Length = 698 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S+FF+ I Sbjct: 627 PLSNFFDVI 635>XP_006718437 Length = 758 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S+FF+ I Sbjct: 687 PLSNFFDVI 695>NP_006032 Length = 390 Score = 16.5 bits (31), Expect = 4312 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 1 PISSFF 6 PISSFF Sbjct: 124 PISSFF 129>NP_002214 Length = 2701 Score = 16.5 bits (31), Expect = 4312 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+SS+FE + Sbjct: 899 PMSSYFERL 907>XP_005261469 Length = 394 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 PIS F ET+ Sbjct: 131 PISPFSETV 139>XP_006719127 Length = 1865 Score = 16.5 bits (31), Expect = 4312 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+SS+FE + Sbjct: 899 PMSSYFERL 907>NP_055107 Length = 412 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 PIS F ET+ Sbjct: 149 PISPFSETV 157>NP_005453 Length = 1142 Score = 16.2 bits (30), Expect = 5631 Identities = 5/6 (83%), Positives = 6/6 (100%) Query: 1 PISSFF 6 P+SSFF Sbjct: 778 PVSSFF 783>XP_003846820 Length = 1177 Score = 16.2 bits (30), Expect = 5631 Identities = 5/6 (83%), Positives = 6/6 (100%) Query: 1 PISSFF 6 P+SSFF Sbjct: 813 PVSSFF 818>NP_001138596 Length = 1188 Score = 16.2 bits (30), Expect = 5631 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 2 ISSFFETI 9 I FFETI Sbjct: 1019 IKQFFETI 1026>NP_114478 Length = 828 Score = 16.2 bits (30), Expect = 5631 Identities = 5/6 (83%), Positives = 6/6 (100%) Query: 1 PISSFF 6 P+SSFF Sbjct: 808 PVSSFF 813>NP_001128302 Length = 1196 Score = 15.8 bits (29), Expect = 7355 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 1 PISSFFE 7 P+SS++E Sbjct: 387 PVSSYYE 393>NP_060121 Length = 1196 Score = 15.8 bits (29), Expect = 7355 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 1 PISSFFE 7 P+SS++E Sbjct: 387 PVSSYYE 393>NP_001128303 Length = 1196 Score = 15.8 bits (29), Expect = 7355 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 1 PISSFFE 7 P+SS++E Sbjct: 387 PVSSYYE 393>NP_001128304 Length = 1053 Score = 15.8 bits (29), Expect = 7355 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 1 PISSFFE 7 P+SS++E Sbjct: 387 PVSSYYE 393>NP_000349 Length = 683 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S+ +ET+ Sbjct: 102 PLSNLYETL 110>NP_001185924 Length = 414 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S +FE++ Sbjct: 381 PVSDWFESL 389>NP_001185923 Length = 591 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S +FE++ Sbjct: 558 PVSDWFESL 566>NP_075394 Length = 446 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S +FE++ Sbjct: 413 PVSDWFESL 421>NP_001185922 Length = 446 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S +FE++ Sbjct: 413 PVSDWFESL 421>NP_073622 Length = 1501 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P S+FF+T Sbjct: 746 PYSAFFKT 753>NP_149095 Length = 905 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P S+FFE Sbjct: 330 PFSAFFE 336>NP_001243359 Length = 920 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P S+FFE Sbjct: 330 PFSAFFE 336>NP_075068 Length = 1146 Score = 15.8 bits (29), Expect = 7355 Identities = 5/9 (55%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 P SF+ET+ Sbjct: 706 PAFSFYETL 714>XP_006724360 Length = 885 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P S+FF+T Sbjct: 44 PYSAFFKT 51>XP_006724359 Length = 1424 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P S+FF+T Sbjct: 746 PYSAFFKT 753>XP_005261762 Length = 1481 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P S+FF+T Sbjct: 640 PYSAFFKT 647>XP_005261761 Length = 1587 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P S+FF+T Sbjct: 746 PYSAFFKT 753>XP_006720344 Length = 702 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P S+FFE Sbjct: 127 PFSAFFE 133>XP_006720343 Length = 751 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P S+FFE Sbjct: 176 PFSAFFE 182>XP_006720342 Length = 898 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P S+FFE Sbjct: 330 PFSAFFE 336>XP_005267096 Length = 1168 Score = 15.8 bits (29), Expect = 7355 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 1 PISSFFE 7 P+SS++E Sbjct: 387 PVSSYYE 393>XP_006715570 Length = 1179 Score = 15.8 bits (29), Expect = 7355 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 1 PISSFFE 7 P+SS++E Sbjct: 387 PVSSYYE 393>XP_006710902 Length = 550 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S +FE++ Sbjct: 517 PVSDWFESL 525>XP_006710901 Length = 359 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S +FE++ Sbjct: 326 PVSDWFESL 334>XP_006710900 Length = 446 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S +FE++ Sbjct: 413 PVSDWFESL 421>XP_005244835 Length = 446 Score = 15.8 bits (29), Expect = 7355 Identities = 4/9 (44%), Positives = 8/9 (88%) Query: 1 PISSFFETI 9 P+S +FE++ Sbjct: 413 PVSDWFESL 421>NP_942153 Length = 1349 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P S+FF+T Sbjct: 594 PYSAFFKT 601>NP_001121084 Length = 422 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 286 PISSSFST 293>NP_000271 Length = 422 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 286 PISSSFST 293>NP_079437 Length = 881 Score = 15.4 bits (28), Expect = 9605 Identities = 4/8 (50%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P+++F ET Sbjct: 675 PVATFLET 682>NP_001245394 Length = 422 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 286 PISSSFST 293>NP_005236 Length = 4588 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P+SSF E Sbjct: 1118 PLSSFIE 1124>NP_001245393 Length = 422 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 286 PISSSFST 293>NP_001245391 Length = 436 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 300 PISSSFST 307>NP_001245392 Length = 436 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 300 PISSSFST 307>NP_001595 Length = 436 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 300 PISSSFST 307>NP_008957 Length = 198 Score = 15.4 bits (28), Expect = 9605 Identities = 4/9 (44%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 PI +F+T+ Sbjct: 85 PIGLYFDTV 93>NP_054730 Length = 536 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P S+FF+T Sbjct: 242 PHSTFFDT 249>NP_653327 Length = 691 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 ISSFFETI 9 +SSFF+ I Sbjct: 59 VSSFFQQI 66>NP_001186312 Length = 663 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 ISSFFETI 9 +SSFF+ I Sbjct: 31 VSSFFQQI 38>NP_001186311 Length = 677 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 ISSFFETI 9 +SSFF+ I Sbjct: 45 VSSFFQQI 52>NP_001186310 Length = 680 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 ISSFFETI 9 +SSFF+ I Sbjct: 48 VSSFFQQI 55>NP_001186309 Length = 693 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 ISSFFETI 9 +SSFF+ I Sbjct: 61 VSSFFQQI 68>XP_006725363 Length = 198 Score = 15.4 bits (28), Expect = 9605 Identities = 4/9 (44%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 PI +F+T+ Sbjct: 85 PIGLYFDTV 93>XP_006722175 Length = 730 Score = 15.4 bits (28), Expect = 9605 Identities = 4/8 (50%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P+++F ET Sbjct: 524 PVATFLET 531>XP_005257034 Length = 198 Score = 15.4 bits (28), Expect = 9605 Identities = 4/9 (44%), Positives = 7/9 (77%) Query: 1 PISSFFETI 9 PI +F+T+ Sbjct: 85 PIGLYFDTV 93>XP_005253015 Length = 286 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 150 PISSSFST 157>XP_006718309 Length = 355 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 219 PISSSFST 226>XP_006718308 Length = 369 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 233 PISSSFST 240>XP_006718307 Length = 377 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 241 PISSSFST 248>XP_005253014 Length = 415 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 300 PISSSFST 307>XP_005253013 Length = 422 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 286 PISSSFST 293>XP_005253012 Length = 422 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 286 PISSSFST 293>XP_005253011 Length = 436 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 6/8 (75%) Query: 1 PISSFFET 8 PISS F T Sbjct: 300 PISSSFST 307>XP_005265883 Length = 679 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 ISSFFETI 9 +SSFF+ I Sbjct: 47 VSSFFQQI 54>XP_006714202 Length = 4588 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P+SSF E Sbjct: 1118 PLSSFIE 1124>XP_005262892 Length = 4600 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P+SSF E Sbjct: 1118 PLSSFIE 1124>XP_005262891 Length = 4600 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PISSFFE 7 P+SSF E Sbjct: 1118 PLSSFIE 1124>NP_659198 Length = 536 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 PISSFFET 8 P S+FF+T Sbjct: 242 PHSTFFDT 249Database: HUMAN_PROTEOME_FASTA Posted date: May 26, 2014 10:46 AM Number of letters in database: 45,948,801 Number of sequences in database: 71,491 Lambda K H 0.328 0.142 0.408 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 71491 Number of Hits to DB: 495,694 Number of extensions: 914 Number of successful extensions: 84 Number of sequences better than 10000.0: 84 Number of HSP's gapped: 84 Number of HSP's successfully gapped: 84 Length of query: 9 Length of database: 45,948,801 Length adjustment: 0 Effective length of query: 9 Effective length of database: 45,948,801 Effective search space: 413539209 Effective search space used: 413539209 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 28 (16.1 bits) S2: 28 (15.4 bits)
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CANCERTOPE | Raghava's Group | IMTECH | CSIR | CRDD | GPSR Package |