Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              19     665
XP_005248577                                                           19     665
XP_005248576                                                           19     665
NP_006362                                                              17    3301
NP_003820                                                              17    4312
NP_001248335                                                           17    4312
NP_001248336                                                           17    4312
NP_001182192                                                           17    4312
XP_006718038                                                           17    4312
XP_005251680                                                           17    4312
XP_006716954                                                           17    4312
XP_006716953                                                           17    4312
XP_006716952                                                           17    4312
XP_006716951                                                           17    4312
XP_006716950                                                           17    4312
XP_006716949                                                           17    4312
XP_006716948                                                           17    4312
XP_005251679                                                           17    4312
NP_116165                                                              16    5631
NP_001269877                                                           16    5631
NP_001273696                                                           16    5631
NP_001127695                                                           16    5631
NP_073743                                                              16    5631
XP_005269685                                                           16    5631
XP_005269684                                                           16    5631
XP_005269683                                                           16    5631
XP_005269681                                                           16    5631
XP_006717770                                                           16    5631
XP_005269679                                                           16    5631
NP_001250                                                              16    7355
NP_001138778                                                           16    7355
NP_002438                                                              16    7355
NP_001231866                                                           16    7355
NP_932765                                                              16    7355
NP_055987                                                              16    7355
NP_001186766                                                           16    7355
NP_597719                                                              16    7355
NP_001036066                                                           16    7355
NP_056437                                                              16    7355
NP_001275511                                                           16    7355
XP_006715898                                                           16    7355
XP_006713568                                                           16    7355
XP_006713567                                                           16    7355
XP_005265227                                                           16    7355
XP_005245087                                                           16    7355
XP_005245086                                                           16    7355
XP_005245085                                                           16    7355
XP_005245084                                                           16    7355
XP_006711302                                                           16    7355
XP_005245083                                                           16    7355
XP_005245082                                                           16    7355
XP_005245081                                                           16    7355
XP_005245080                                                           16    7355
XP_005245079                                                           16    7355
XP_005245077                                                           16    7355
XP_005245076                                                           16    7355
XP_006711301                                                           16    7355
XP_005245075                                                           16    7355
XP_005245074                                                           16    7355
XP_005245073                                                           16    7355
XP_005245072                                                           16    7355
NP_001271209                                                           15    9605
NP_001271210                                                           15    9605
XP_006726472                                                           15    9605
XP_006721355                                                           15    9605
XP_005267899                                                           15    9605
XP_006720257                                                           15    9605
XP_005263207                                                           15    9605
XP_006713899                                                           15    9605
XP_006710217                                                           15    9605
NP_065775                                                              15    9605
>NP_005912
          Length = 1512

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IQKFVSRM 9
           IQKFVSRM
Sbjct: 408 IQKFVSRM 415
>XP_005248577
          Length = 1349

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IQKFVSRM 9
           IQKFVSRM
Sbjct: 245 IQKFVSRM 252
>XP_005248576
          Length = 1375

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IQKFVSRM 9
           IQKFVSRM
Sbjct: 271 IQKFVSRM 278
>NP_006362
          Length = 401

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PIQKFVSRM 9
           P++KFV+ M
Sbjct: 289 PVEKFVATM 297
>NP_003820
          Length = 2041

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1541 PIEKFIS 1547
>NP_001248335
          Length = 2037

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1508 PIEKFIS 1514
>NP_001248336
          Length = 2008

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1508 PIEKFIS 1514
>NP_001182192
          Length = 1033

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PIQKFVS 7
           P+QKFV+
Sbjct: 513 PVQKFVT 519
>XP_006718038
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PIQKFVS 7
           P+QKFV+
Sbjct: 513 PVQKFVT 519
>XP_005251680
          Length = 2000

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1471 PIEKFIS 1477
>XP_006716954
          Length = 2008

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1508 PIEKFIS 1514
>XP_006716953
          Length = 2031

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1502 PIEKFIS 1508
>XP_006716952
          Length = 2037

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1508 PIEKFIS 1514
>XP_006716951
          Length = 2041

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1541 PIEKFIS 1547
>XP_006716950
          Length = 2070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1541 PIEKFIS 1547
>XP_006716949
          Length = 2070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1541 PIEKFIS 1547
>XP_006716948
          Length = 2070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1541 PIEKFIS 1547
>XP_005251679
          Length = 2070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PIQKFVS 7
            PI+KF+S
Sbjct: 1541 PIEKFIS 1547
>NP_116165
          Length = 2540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIQKFVSR 8
           P +KFVSR
Sbjct: 495 PKEKFVSR 502
>NP_001269877
          Length = 2358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIQKFVSR 8
           P +KFVSR
Sbjct: 313 PKEKFVSR 320
>NP_001273696
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  PIQKFVSRM 9
          P +KF+SR+
Sbjct: 86 PPKKFISRL 94
>NP_001127695
          Length = 359

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  PIQKFVSRM 9
          P +KF+SR+
Sbjct: 91 PPKKFISRL 99
>NP_073743
          Length = 366

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PIQKFVSRM 9
           P +KF+SR+
Sbjct: 98  PPKKFISRL 106
>XP_005269685
          Length = 1700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIQKFVSR 8
           P +KFVSR
Sbjct: 495 PKEKFVSR 502
>XP_005269684
          Length = 2032

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIQKFVSR 8
           P +KFVSR
Sbjct: 495 PKEKFVSR 502
>XP_005269683
          Length = 2252

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIQKFVSR 8
           P +KFVSR
Sbjct: 207 PKEKFVSR 214
>XP_005269681
          Length = 2321

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIQKFVSR 8
           P +KFVSR
Sbjct: 276 PKEKFVSR 283
>XP_006717770
          Length = 2358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIQKFVSR 8
           P +KFVSR
Sbjct: 313 PKEKFVSR 320
>XP_005269679
          Length = 2502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIQKFVSR 8
           P +KFVSR
Sbjct: 457 PKEKFVSR 464
>NP_001250
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PIQKFVS 7
           PI+KFV+
Sbjct: 261 PIEKFVT 267
>NP_001138778
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PIQKFVS 7
           PI+KFV+
Sbjct: 261 PIEKFVT 267
>NP_002438
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PIQKFVSRM 9
           P+Q+ VSR+
Sbjct: 497 PVQRDVSRL 505
>NP_001231866
          Length = 1351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PIQKFVSRM 9
           P+Q+ VSR+
Sbjct: 497 PVQRDVSRL 505
>NP_932765
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IQKFVSRM 9
           IQ F++RM
Sbjct: 206 IQSFINRM 213
>NP_055987
          Length = 2817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 871 VQKFLSR 877
>NP_001186766
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 PIQKFVS 7
         P+Q+FVS
Sbjct: 3 PLQEFVS 9
>NP_597719
          Length = 770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IQKFVSR 8
          IQKF+S+
Sbjct: 64 IQKFISK 70
>NP_001036066
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IQKFVSR 8
          IQKF+S+
Sbjct: 64 IQKFISK 70
>NP_056437
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IQKFVSRM 9
           IQ F++RM
Sbjct: 206 IQSFINRM 213
>NP_001275511
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IQKFVSR 8
          IQKF+S+
Sbjct: 64 IQKFISK 70
>XP_006715898
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PIQKFVS 7
           PI+KFV+
Sbjct: 261 PIEKFVT 267
>XP_006713568
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IQKFVSR 8
          IQKF+S+
Sbjct: 64 IQKFISK 70
>XP_006713567
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IQKFVSR 8
          IQKF+S+
Sbjct: 64 IQKFISK 70
>XP_005265227
          Length = 1401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PIQKFVSRM 9
           P+Q+ VSR+
Sbjct: 497 PVQRDVSRL 505
>XP_005245087
          Length = 2708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245086
          Length = 2714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245085
          Length = 2718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245084
          Length = 2719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_006711302
          Length = 2754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245083
          Length = 2774

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245082
          Length = 2779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245081
          Length = 2819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245080
          Length = 2824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245079
          Length = 2838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245077
          Length = 2858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245076
          Length = 2869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_006711301
          Length = 2896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 871 VQKFLSR 877
>XP_005245075
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 868 VQKFLSR 874
>XP_005245074
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>XP_005245073
          Length = 2901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 871 VQKFLSR 877
>XP_005245072
          Length = 2903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QKF+SR
Sbjct: 873 VQKFLSR 879
>NP_001271209
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PIQKFVSR 8
           PI KF+ R
Sbjct: 699 PISKFMER 706
>NP_001271210
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PIQKFVSR 8
           PI KF+ R
Sbjct: 473 PISKFMER 480
>XP_006726472
          Length = 169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PIQKFVS 7
          PI+K+VS
Sbjct: 46 PIRKYVS 52
>XP_006721355
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQKFVSRM 9
           +++FV+RM
Sbjct: 293 VERFVTRM 300
>XP_005267899
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PIQKFVSR 8
           PI KF+ R
Sbjct: 712 PISKFMER 719
>XP_006720257
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PIQKFVSR 8
           PI KF+ R
Sbjct: 712 PISKFMER 719
>XP_005263207
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QK+VSR
Sbjct: 222 LQKYVSR 228
>XP_006713899
          Length = 169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PIQKFVS 7
          PI+K+VS
Sbjct: 46 PIRKYVS 52
>XP_006710217
          Length = 169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PIQKFVS 7
          PI+K+VS
Sbjct: 46 PIRKYVS 52
>NP_065775
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IQKFVSR 8
           +QK+VSR
Sbjct: 200 LQKYVSR 206
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.141    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 403,638
Number of extensions: 826
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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