Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              20     299
NP_001073121                                                           18    1135
NP_689957                                                              18    1135
NP_001185617                                                           17    2528
NP_001003680                                                           17    2528
NP_001185616                                                           17    2528
NP_002294                                                              17    2528
NP_001003679                                                           17    2528
NP_001185618                                                           17    2528
NP_777367                                                              17    4312
NP_001182723                                                           17    4312
NP_443721                                                              17    4312
NP_001155130                                                           17    4312
NP_001155131                                                           17    4312
NP_001155132                                                           17    4312
NP_001155128                                                           17    4312
NP_001155129                                                           17    4312
NP_001123644                                                           17    4312
NP_001123645                                                           17    4312
NP_005366                                                              17    4312
NP_001139146                                                           17    4312
NP_066547                                                              17    4312
NP_001257700                                                           17    4312
NP_077015                                                              17    4312
XP_006715558                                                           17    4312
NP_006217                                                              16    5631
NP_055620                                                              16    5631
XP_005246701                                                           16    5631
XP_005246700                                                           16    5631
NP_001139784                                                           16    7355
NP_705832                                                              16    7355
NP_001477                                                              16    7355
NP_056190                                                              16    7355
NP_955749                                                              16    7355
NP_001243070                                                           16    7355
NP_060516                                                              16    7355
NP_060903                                                              16    7355
NP_001140160                                                           16    7355
XP_005256921                                                           16    7355
XP_005256920                                                           16    7355
XP_005264314                                                           16    7355
XP_005264313                                                           16    7355
NP_787114                                                              16    7355
NP_060773                                                              15    9605
NP_116206                                                              15    9605
NP_001273409                                                           15    9605
NP_055598                                                              15    9605
NP_848511                                                              15    9605
NP_955389                                                              15    9605
NP_085046                                                              15    9605
NP_001001851                                                           15    9605
NP_001273408                                                           15    9605
NP_008948                                                              15    9605
XP_006725627                                                           15    9605
XP_006720851                                                           15    9605
XP_006715205                                                           15    9605
XP_006715204                                                           15    9605
>NP_055365
          Length = 1032

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           PI IHVEVT
Sbjct: 939 PIVIHVEVT 947
>NP_001073121
          Length = 679

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           PIA+H E+T
Sbjct: 124 PIALHAELT 132
>NP_689957
          Length = 2213

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PIAIHVEVT 9
            PIA+H E+T
Sbjct: 1637 PIALHAELT 1645
>NP_001185617
          Length = 906

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+ +H+E+T
Sbjct: 240 PLGLHMEIT 248
>NP_001003680
          Length = 958

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+ +H+E+T
Sbjct: 240 PLGLHMEIT 248
>NP_001185616
          Length = 958

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+ +H+E+T
Sbjct: 240 PLGLHMEIT 248
>NP_002294
          Length = 1165

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+ +H+E+T
Sbjct: 240 PLGLHMEIT 248
>NP_001003679
          Length = 896

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+ +H+E+T
Sbjct: 240 PLGLHMEIT 248
>NP_001185618
          Length = 896

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+ +H+E+T
Sbjct: 240 PLGLHMEIT 248
>NP_777367
          Length = 232

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P++IHV V
Sbjct: 94  PVSIHVNV 101
>NP_001182723
          Length = 245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P++IHV V
Sbjct: 94  PVSIHVNV 101
>NP_443721
          Length = 120

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PIAIHVEV 8
          P++IHV V
Sbjct: 18 PVSIHVNV 25
>NP_001155130
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_001155131
          Length = 603

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_001155132
          Length = 605

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_001155128
          Length = 758

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_001155129
          Length = 555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_001123644
          Length = 637

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_001123645
          Length = 761

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_005366
          Length = 640

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_001139146
          Length = 1004

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAIHVEVT 9
           + IH+EVT
Sbjct: 481 VPIHIEVT 488
>NP_066547
          Length = 1100

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAIHVEVT 9
           + IH+EVT
Sbjct: 577 VPIHIEVT 584
>NP_001257700
          Length = 1200

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAIHVEVT 9
           + IH+EVT
Sbjct: 677 VPIHIEVT 684
>NP_077015
          Length = 1004

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PIAIHVEV 8
           PI IHV V
Sbjct: 920 PIVIHVSV 927
>XP_006715558
          Length = 449

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+A+HV +
Sbjct: 262 PVALHVNI 269
>NP_006217
          Length = 1095

 Score = 16.2 bits (30), Expect =  5631
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   PIAIHVEV 8
           P+A+H+++
Sbjct: 720 PLALHIKI 727
>NP_055620
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           PI++ VE+T
Sbjct: 500 PISVRVELT 508
>XP_005246701
          Length = 1016

 Score = 16.2 bits (30), Expect =  5631
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   PIAIHVEV 8
           P+A+H+++
Sbjct: 641 PLALHIKI 648
>XP_005246700
          Length = 1021

 Score = 16.2 bits (30), Expect =  5631
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   PIAIHVEV 8
           P+A+H+++
Sbjct: 646 PLALHIKI 653
>NP_001139784
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PIAIHVEV 8
           PIA+H  V
Sbjct: 231 PIAVHAAV 238
>NP_705832
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PIAIHVEV 8
           PIA+H  V
Sbjct: 231 PIAVHAAV 238
>NP_001477
          Length = 625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           PI+ HV+V
Sbjct: 556 PISCHVQV 563
>NP_056190
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AIHVEVT 9
           A HVEVT
Sbjct: 524 AYHVEVT 530
>NP_955749
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AIHVEVT 9
           A HVEVT
Sbjct: 524 AYHVEVT 530
>NP_001243070
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           P+AI VEV
Sbjct: 147 PVAITVEV 154
>NP_060516
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PIAIHVEVT 9
           P ++H E+T
Sbjct: 610 PASVHSEIT 618
>NP_060903
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PIAIHVEV 8
           P  IHVEV
Sbjct: 236 PSLIHVEV 243
>NP_001140160
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PIAIHVEV 8
           P  IHVEV
Sbjct: 236 PSLIHVEV 243
>XP_005256921
          Length = 907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PIAIHVEV 8
           PIA+H  V
Sbjct: 152 PIAVHAAV 159
>XP_005256920
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PIAIHVEV 8
           PIA+H  V
Sbjct: 231 PIAVHAAV 238
>XP_005264314
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           PI+ HV+V
Sbjct: 533 PISCHVQV 540
>XP_005264313
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PIAIHVEV 8
           PI+ HV+V
Sbjct: 554 PISCHVQV 561
>NP_787114
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IAIHVEVT 9
           I++H+E+T
Sbjct: 439 ISLHLEIT 446
>NP_060773
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IAIHVEV 8
           IA+H EV
Sbjct: 807 IAVHAEV 813
>NP_116206
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IHVEVT 9
           +HVEVT
Sbjct: 312 LHVEVT 317
>NP_001273409
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 2/9 (22%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+++H++ +
Sbjct: 177 PVSVHIDTS 185
>NP_055598
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 2/9 (22%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+++H++ +
Sbjct: 366 PVSVHIDTS 374
>NP_848511
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PIAIHVE 7
           P+A+HV+
Sbjct: 130 PLALHVK 136
>NP_955389
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 2/9 (22%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+++H++ +
Sbjct: 366 PVSVHIDTS 374
>NP_085046
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IHVEVT 9
           +HVEVT
Sbjct: 526 LHVEVT 531
>NP_001001851
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IHVEVT 9
           +HVEVT
Sbjct: 526 LHVEVT 531
>NP_001273408
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 2/9 (22%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+++H++ +
Sbjct: 177 PVSVHIDTS 185
>NP_008948
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   PIAIHVE 7
           P+A+HV+
Sbjct: 130 PLALHVK 136
>XP_006725627
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 2/9 (22%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+++H++ +
Sbjct: 366 PVSVHIDTS 374
>XP_006720851
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 2/9 (22%), Positives = 8/9 (88%)

Query: 1   PIAIHVEVT 9
           P+++H++ +
Sbjct: 177 PVSVHIDTS 185
>XP_006715205
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IAIHVEV 8
           IA+H EV
Sbjct: 807 IAVHAEV 813
>XP_006715204
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IAIHVEV 8
           IA+H EV
Sbjct: 807 IAVHAEV 813
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.138    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 559,808
Number of extensions: 776
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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