Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              21     229
NP_001120972                                                           21     229
XP_006716052                                                           21     229
XP_006716051                                                           21     229
NP_787118                                                              20     509
NP_001170785                                                           17    3301
NP_036382                                                              17    3301
NP_001170786                                                           17    3301
NP_001096139                                                           17    3301
NP_037403                                                              17    3301
NP_940857                                                              17    4312
NP_852466                                                              16    5631
NP_001153199                                                           16    5631
NP_071338                                                              16    5631
NP_060363                                                              16    5631
XP_005270067                                                           16    5631
XP_005270066                                                           16    5631
XP_005270065                                                           16    5631
XP_006713189                                                           16    5631
XP_005265159                                                           16    5631
NP_775813                                                              16    5631
NP_005904                                                              16    7355
NP_937790                                                              16    7355
NP_898871                                                              15    9605
NP_000047                                                              15    9605
NP_055490                                                              15    9605
NP_001073893                                                           15    9605
NP_005293                                                              15    9605
NP_001243114                                                           15    9605
NP_848018                                                              15    9605
NP_001245134                                                           15    9605
NP_054730                                                              15    9605
NP_001274742                                                           15    9605
NP_001274743                                                           15    9605
NP_061840                                                              15    9605
NP_659505                                                              15    9605
NP_665803                                                              15    9605
NP_001243117                                                           15    9605
NP_037478                                                              15    9605
XP_006724706                                                           15    9605
XP_006724705                                                           15    9605
XP_006721547                                                           15    9605
XP_005256611                                                           15    9605
XP_005256609                                                           15    9605
XP_005256607                                                           15    9605
XP_005256608                                                           15    9605
XP_006721546                                                           15    9605
XP_005256606                                                           15    9605
XP_005273940                                                           15    9605
XP_006716519                                                           15    9605
XP_005248813                                                           15    9605
XP_006711123                                                           15    9605
XP_006711122                                                           15    9605
XP_006711121                                                           15    9605
XP_006711120                                                           15    9605
XP_006711119                                                           15    9605
NP_659198                                                              15    9605
>NP_000236
          Length = 1390

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PGAQLARQL 9
           PGAQLARQ+
Sbjct: 325 PGAQLARQI 333
>NP_001120972
          Length = 1408

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PGAQLARQL 9
           PGAQLARQ+
Sbjct: 325 PGAQLARQI 333
>XP_006716052
          Length = 1409

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PGAQLARQL 9
           PGAQLARQ+
Sbjct: 344 PGAQLARQI 352
>XP_006716051
          Length = 1427

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PGAQLARQL 9
           PGAQLARQ+
Sbjct: 344 PGAQLARQI 352
>NP_787118
          Length = 295

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  PGAQLARQL 9
          PGAQ ARQL
Sbjct: 14 PGAQAARQL 22
>NP_001170785
          Length = 169

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GAQLARQL 9
           G QLARQL
Sbjct: 107 GQQLARQL 114
>NP_036382
          Length = 204

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GAQLARQL 9
           G QLARQL
Sbjct: 142 GQQLARQL 149
>NP_001170786
          Length = 127

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  GAQLARQL 9
          G QLARQL
Sbjct: 65 GQQLARQL 72
>NP_001096139
          Length = 127

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  GAQLARQL 9
          G QLARQL
Sbjct: 65 GQQLARQL 72
>NP_037403
          Length = 260

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   PGAQLARQL 9
           P AQLAR L
Sbjct: 132 PAAQLARAL 140
>NP_940857
          Length = 5147

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    PGAQLAR 7
            PGA+LAR
Sbjct: 3378 PGARLAR 3384
>NP_852466
          Length = 1031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PGAQLARQL 9
          PG +L RQL
Sbjct: 49 PGQELFRQL 57
>NP_001153199
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PGAQLARQL 9
          PG+ LAR L
Sbjct: 9  PGSHLARAL 17
>NP_071338
          Length = 430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PGAQLARQ 8
           PGA LAR+
Sbjct: 325 PGAPLARR 332
>NP_060363
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PGAQLA 6
           PGAQLA
Sbjct: 670 PGAQLA 675
>XP_005270067
          Length = 838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PGAQLA 6
           PGAQLA
Sbjct: 665 PGAQLA 670
>XP_005270066
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PGAQLA 6
           PGAQLA
Sbjct: 670 PGAQLA 675
>XP_005270065
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PGAQLA 6
           PGAQLA
Sbjct: 670 PGAQLA 675
>XP_006713189
          Length = 1019

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PGAQLARQL 9
          PG +L RQL
Sbjct: 49 PGQELFRQL 57
>XP_005265159
          Length = 1031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PGAQLARQL 9
          PG +L RQL
Sbjct: 49 PGQELFRQL 57
>NP_775813
          Length = 589

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PGAQLARQL 9
          PG+ LAR L
Sbjct: 9  PGSHLARAL 17
>NP_005904
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PGAQLARQ 8
           PGA  ARQ
Sbjct: 223 PGASSARQ 230
>NP_937790
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGAQLARQ 8
           PG +LAR+
Sbjct: 118 PGPELARE 125
>NP_898871
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PGAQLAR 7
          PGA LAR
Sbjct: 27 PGAGLAR 33
>NP_000047
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PGAQLAR 7
          PGA LAR
Sbjct: 27 PGAGLAR 33
>NP_055490
          Length = 2017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AQLARQL 9
           AQL+RQL
Sbjct: 837 AQLSRQL 843
>NP_001073893
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGAQLARQ 8
          PGA+ AR+
Sbjct: 8  PGARAARE 15
>NP_005293
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PGAQLAR 7
          PGA LAR
Sbjct: 4  PGALLAR 10
>NP_001243114
          Length = 162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PGAQLARQL 9
           PG  L RQL
Sbjct: 94  PGKALKRQL 102
>NP_848018
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PGAQLARQL 9
           PG++ AR+L
Sbjct: 152 PGSRRAREL 160
>NP_001245134
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGAQLARQ 8
           P AQLA++
Sbjct: 103 PSAQLAKE 110
>NP_054730
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGAQLARQ 8
           PG +LAR+
Sbjct: 104 PGTRLARR 111
>NP_001274742
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PGAQLARQ 8
           PG  L+RQ
Sbjct: 221 PGTDLSRQ 228
>NP_001274743
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PGAQLARQ 8
           PG  L+RQ
Sbjct: 221 PGTDLSRQ 228
>NP_061840
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PGAQLARQ 8
           PG  L+RQ
Sbjct: 221 PGTDLSRQ 228
>NP_659505
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGAQLARQ 8
           P AQLA++
Sbjct: 103 PSAQLAKE 110
>NP_665803
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PGAQLARQ 8
           PGA  ARQ
Sbjct: 362 PGASPARQ 369
>NP_001243117
          Length = 158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PGAQLARQL 9
          PG  L RQL
Sbjct: 90 PGKALKRQL 98
>NP_037478
          Length = 162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PGAQLARQL 9
           PG  L RQL
Sbjct: 94  PGKALKRQL 102
>XP_006724706
          Length = 108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PGAQLARQL 9
          PG  L RQL
Sbjct: 40 PGKALKRQL 48
>XP_006724705
          Length = 117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  PGAQLARQL 9
          PG  L RQL
Sbjct: 49 PGKALKRQL 57
>XP_006721547
          Length = 1638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGAQLARQ 8
          PGA+ AR+
Sbjct: 8  PGARAARE 15
>XP_005256611
          Length = 1643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGAQLARQ 8
          PGA+ AR+
Sbjct: 8  PGARAARE 15
>XP_005256609
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGAQLARQ 8
          PGA+ AR+
Sbjct: 8  PGARAARE 15
>XP_005256607
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGAQLARQ 8
          PGA+ AR+
Sbjct: 8  PGARAARE 15
>XP_005256608
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGAQLARQ 8
          PGA+ AR+
Sbjct: 8  PGARAARE 15
>XP_006721546
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGAQLARQ 8
          PGA+ AR+
Sbjct: 8  PGARAARE 15
>XP_005256606
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGAQLARQ 8
          PGA+ AR+
Sbjct: 8  PGARAARE 15
>XP_005273940
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGAQLARQ 8
           PG+QLA +
Sbjct: 274 PGSQLAHK 281
>XP_006716519
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PGAQLARQ 8
           PG  L+RQ
Sbjct: 221 PGTDLSRQ 228
>XP_005248813
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PGAQLAR 7
          PGA LAR
Sbjct: 27 PGAGLAR 33
>XP_006711123
          Length = 1737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AQLARQL 9
           AQL+RQL
Sbjct: 799 AQLSRQL 805
>XP_006711122
          Length = 1918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AQLARQL 9
           AQL+RQL
Sbjct: 799 AQLSRQL 805
>XP_006711121
          Length = 1945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AQLARQL 9
           AQL+RQL
Sbjct: 765 AQLSRQL 771
>XP_006711120
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AQLARQL 9
           AQL+RQL
Sbjct: 799 AQLSRQL 805
>XP_006711119
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AQLARQL 9
           AQL+RQL
Sbjct: 799 AQLSRQL 805
>NP_659198
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGAQLARQ 8
           PG +LAR+
Sbjct: 104 PGTRLARR 111
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.134    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 550,665
Number of extensions: 987
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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