Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           21     229
NP_001257437                                                           21     229
NP_006281                                                              21     229
XP_006715618                                                           21     229
XP_005267176                                                           21     229
NP_003704                                                              17    4312
NP_001159743                                                           16    5631
NP_001273721                                                           16    5631
NP_001269701                                                           16    5631
NP_694568                                                              16    5631
NP_002829                                                              16    5631
NP_061887                                                              16    5631
NP_001269703                                                           16    5631
NP_001269706                                                           16    5631
NP_001269708                                                           16    5631
NP_001269705                                                           16    5631
NP_001131076                                                           16    5631
NP_001181988                                                           16    5631
XP_006711535                                                           16    5631
NP_079477                                                              16    5631
NP_001078921                                                           16    7355
NP_056482                                                              16    7355
NP_001244068                                                           16    7355
NP_004704                                                              16    7355
NP_004061                                                              16    7355
NP_001076593                                                           16    7355
NP_001107013                                                           16    7355
XP_005268258                                                           16    7355
XP_005268257                                                           16    7355
XP_005268256                                                           16    7355
XP_006710134                                                           16    7355
NP_001138668                                                           16    7355
NP_001135389                                                           16    7355
NP_001036169                                                           16    7355
NP_054706                                                              15    9605
NP_003364                                                              15    9605
NP_000350                                                              15    9605
NP_001139                                                              15    9605
NP_065759                                                              15    9605
NP_001128243                                                           15    9605
NP_055633                                                              15    9605
NP_055617                                                              15    9605
NP_001273106                                                           15    9605
NP_001273105                                                           15    9605
NP_001273104                                                           15    9605
NP_001273103                                                           15    9605
NP_001273102                                                           15    9605
NP_110419                                                              15    9605
NP_005015                                                              15    9605
XP_005253595                                                           15    9605
XP_006719233                                                           15    9605
XP_006719232                                                           15    9605
XP_006719231                                                           15    9605
XP_006719230                                                           15    9605
XP_006719229                                                           15    9605
XP_006719228                                                           15    9605
XP_006719227                                                           15    9605
XP_006718760                                                           15    9605
XP_006718759                                                           15    9605
XP_006718758                                                           15    9605
XP_006718757                                                           15    9605
XP_006718461                                                           15    9605
XP_006718460                                                           15    9605
XP_005270200                                                           15    9605
XP_005270199                                                           15    9605
XP_006714257                                                           15    9605
XP_005263002                                                           15    9605
XP_005262999                                                           15    9605
XP_006714252                                                           15    9605
XP_006714251                                                           15    9605
XP_006714250                                                           15    9605
XP_006713282                                                           15    9605
XP_006713281                                                           15    9605
XP_005265326                                                           15    9605
XP_005265323                                                           15    9605
NP_940877                                                              15    9605
>NP_001257436
          Length = 790

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   PFLFSETT 8
           PFLFSETT
Sbjct: 467 PFLFSETT 474
>NP_001257437
          Length = 790

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   PFLFSETT 8
           PFLFSETT
Sbjct: 467 PFLFSETT 474
>NP_006281
          Length = 790

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   PFLFSETT 8
           PFLFSETT
Sbjct: 467 PFLFSETT 474
>XP_006715618
          Length = 577

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   PFLFSETT 8
           PFLFSETT
Sbjct: 254 PFLFSETT 261
>XP_005267176
          Length = 790

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   PFLFSETT 8
           PFLFSETT
Sbjct: 467 PFLFSETT 474
>NP_003704
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PFLFSETTT 9
          PFL  ET+T
Sbjct: 50 PFLIIETST 58
>NP_001159743
          Length = 1277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFLFSETT 8
           PF FS++T
Sbjct: 697 PFTFSQST 704
>NP_001273721
          Length = 1339

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFLFSETT 8
           PF FS++T
Sbjct: 759 PFTFSQST 766
>NP_001269701
          Length = 1173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PF+FSE
Sbjct: 987 PFIFSE 992
>NP_694568
          Length = 652

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PFLFSETT 8
          PF FS++T
Sbjct: 72 PFTFSQST 79
>NP_002829
          Length = 1306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  FSETTT 9
          FSETTT
Sbjct: 69 FSETTT 74
>NP_061887
          Length = 1135

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PF+FSE
Sbjct: 949 PFIFSE 954
>NP_001269703
          Length = 952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PF+FSE
Sbjct: 766 PFIFSE 771
>NP_001269706
          Length = 996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PF+FSE
Sbjct: 810 PFIFSE 815
>NP_001269708
          Length = 996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PF+FSE
Sbjct: 810 PFIFSE 815
>NP_001269705
          Length = 924

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PF+FSE
Sbjct: 738 PFIFSE 743
>NP_001131076
          Length = 1079

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PF+FSE
Sbjct: 893 PFIFSE 898
>NP_001181988
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PFLFSETTT 9
           PFL  ETT+
Sbjct: 159 PFLAPETTS 167
>XP_006711535
          Length = 1258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  FSETTT 9
          FSETTT
Sbjct: 69 FSETTT 74
>NP_079477
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PFLFSETTT 9
           PFL  ETT+
Sbjct: 209 PFLAPETTS 217
>NP_001078921
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLF+E
Sbjct: 458 PFLFNE 463
>NP_056482
          Length = 1347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLF+E
Sbjct: 444 PFLFNE 449
>NP_001244068
          Length = 644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LFSETT 8
           LFSETT
Sbjct: 592 LFSETT 597
>NP_004704
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLFS+
Sbjct: 275 PFLFSQ 280
>NP_004061
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LFSETT 8
           LFSETT
Sbjct: 635 LFSETT 640
>NP_001076593
          Length = 1347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLF+E
Sbjct: 444 PFLFNE 449
>NP_001107013
          Length = 1347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLF+E
Sbjct: 444 PFLFNE 449
>XP_005268258
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  PFLFSE 6
          PFLFS+
Sbjct: 46 PFLFSQ 51
>XP_005268257
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  PFLFSE 6
          PFLFS+
Sbjct: 61 PFLFSQ 66
>XP_005268256
          Length = 1055

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLFS+
Sbjct: 275 PFLFSQ 280
>XP_006710134
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LFSETT 8
           LFSETT
Sbjct: 282 LFSETT 287
>NP_001138668
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLF+E
Sbjct: 444 PFLFNE 449
>NP_001135389
          Length = 1335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLF+E
Sbjct: 468 PFLFNE 473
>NP_001036169
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LFSETT 8
           LFSETT
Sbjct: 634 LFSETT 639
>NP_054706
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFSETTT 9
           +FS+TTT
Sbjct: 598 VFSDTTT 604
>NP_003364
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFSETTT 9
           +FS+TTT
Sbjct: 598 VFSDTTT 604
>NP_000350
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PFLFSETTT 9
           PF+F+E  +
Sbjct: 492 PFIFAEVNS 500
>NP_001139
          Length = 3957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    PFLFSE 6
            PFLF E
Sbjct: 3100 PFLFQE 3105
>NP_065759
          Length = 1116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PFLFSETTT 9
           P++FS+ T+
Sbjct: 390 PYVFSDMTS 398
>NP_001128243
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PFLFSETTT 9
           P++FS+ T+
Sbjct: 413 PYVFSDMTS 421
>NP_055633
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLFS+
Sbjct: 216 PFLFSK 221
>NP_055617
          Length = 1000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>NP_001273106
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>NP_001273105
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>NP_001273104
          Length = 1054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>NP_001273103
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>NP_001273102
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>NP_110419
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PFLFSETT 8
           PFL  +TT
Sbjct: 271 PFLMHDTT 278
>NP_005015
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PFLFSETTT 9
           PF  +ETT+
Sbjct: 206 PFRINETTS 214
>XP_005253595
          Length = 991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>XP_006719233
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>XP_006719232
          Length = 1033

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>XP_006719231
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>XP_006719230
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>XP_006719229
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>XP_006719228
          Length = 1075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>XP_006719227
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PFLFSETTT 9
           P L+SE  T
Sbjct: 95  PLLYSEAAT 103
>XP_006718760
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PFLFSETT 8
           PFL  +TT
Sbjct: 271 PFLMHDTT 278
>XP_006718759
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PFLFSETT 8
           PFL  +TT
Sbjct: 271 PFLMHDTT 278
>XP_006718758
          Length = 610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PFLFSETT 8
           PFL  +TT
Sbjct: 271 PFLMHDTT 278
>XP_006718757
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PFLFSETT 8
           PFL  +TT
Sbjct: 271 PFLMHDTT 278
>XP_006718461
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLFS+
Sbjct: 216 PFLFSK 221
>XP_006718460
          Length = 1392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PFLFSE 6
           PFLFS+
Sbjct: 361 PFLFSK 366
>XP_005270200
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFSETTT 9
           +FS+TTT
Sbjct: 599 VFSDTTT 605
>XP_005270199
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFSETTT 9
           +FS+TTT
Sbjct: 599 VFSDTTT 605
>XP_006714257
          Length = 4145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    PFLFSE 6
            PFLF E
Sbjct: 3109 PFLFQE 3114
>XP_005263002
          Length = 4072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    PFLFSE 6
            PFLF E
Sbjct: 3067 PFLFQE 3072
>XP_005262999
          Length = 4147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    PFLFSE 6
            PFLF E
Sbjct: 3111 PFLFQE 3116
>XP_006714252
          Length = 4153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    PFLFSE 6
            PFLF E
Sbjct: 3117 PFLFQE 3122
>XP_006714251
          Length = 4165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    PFLFSE 6
            PFLF E
Sbjct: 3129 PFLFQE 3134
>XP_006714250
          Length = 4190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    PFLFSE 6
            PFLF E
Sbjct: 3154 PFLFQE 3159
>XP_006713282
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PFLFSE 6
           PFLF E
Sbjct: 365 PFLFQE 370
>XP_006713281
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PFLFSE 6
           PFLF E
Sbjct: 492 PFLFQE 497
>XP_005265326
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PFLFSE 6
           PFLF E
Sbjct: 532 PFLFQE 537
>XP_005265323
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   PFLFSE 6
           PFLF E
Sbjct: 559 PFLFQE 564
>NP_940877
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFLFSETT 8
           P LF+E+T
Sbjct: 619 PVLFNEST 626
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.131    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 489,809
Number of extensions: 810
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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