Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_002263                                                              17    2528
NP_001186308                                                           17    4312
NP_775898                                                              17    4312
NP_001186307                                                           17    4312
NP_075447                                                              17    4312
NP_004184                                                              17    4312
XP_006721905                                                           17    4312
XP_006721904                                                           17    4312
XP_006721903                                                           17    4312
XP_006721902                                                           17    4312
XP_006721901                                                           17    4312
XP_005257301                                                           17    4312
XP_006721900                                                           17    4312
XP_006718114                                                           17    4312
XP_005270318                                                           17    4312
XP_006718113                                                           17    4312
XP_006718112                                                           17    4312
XP_006718111                                                           17    4312
XP_006718110                                                           17    4312
XP_005273605                                                           17    4312
XP_005273604                                                           17    4312
NP_057427                                                              16    5631
NP_003912                                                              16    5631
XP_005271368                                                           16    5631
NP_787028                                                              16    7355
NP_473366                                                              16    7355
NP_001035536                                                           16    7355
NP_061114                                                              16    7355
XP_006722344                                                           16    7355
XP_005271567                                                           16    7355
XP_005271566                                                           16    7355
XP_005271565                                                           16    7355
XP_005271564                                                           16    7355
XP_005271563                                                           16    7355
XP_005248374                                                           16    7355
XP_005248373                                                           16    7355
XP_005248371                                                           16    7355
XP_005248370                                                           16    7355
NP_004505                                                              16    7355
NP_001177766                                                           15    9605
NP_001128512                                                           15    9605
NP_004073                                                              15    9605
NP_075408                                                              15    9605
NP_001128513                                                           15    9605
NP_001177765                                                           15    9605
NP_003631                                                              15    9605
NP_115642                                                              15    9605
NP_004178                                                              15    9605
NP_001269551                                                           15    9605
NP_001254542                                                           15    9605
NP_659482                                                              15    9605
XP_005262092                                                           15    9605
XP_005252342                                                           15    9605
NP_443073                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PELEVVRTE 9
            PELEVV TE
Sbjct: 2463 PELEVVLTE 2471
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PELEVVRTE 9
            PELEVV TE
Sbjct: 2455 PELEVVLTE 2463
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PELEVVRTE 9
            PELEVV TE
Sbjct: 2416 PELEVVLTE 2424
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PELEVVRTE 9
            PELEVV TE
Sbjct: 2495 PELEVVLTE 2503
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    PELEVVRTE 9
            PELEVV TE
Sbjct: 2508 PELEVVLTE 2516
>NP_002263
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PELEVVRTE 9
           PE++ VRTE
Sbjct: 128 PEIQKVRTE 136
>NP_001186308
          Length = 1855

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>NP_775898
          Length = 282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PELEVVRTE 9
          PELEVV  E
Sbjct: 73 PELEVVYEE 81
>NP_001186307
          Length = 1856

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>NP_075447
          Length = 1437

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    PELEVVRTE 9
            P+ E+++TE
Sbjct: 1145 PDAEIIKTE 1153
>NP_004184
          Length = 1859

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>XP_006721905
          Length = 242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PELEVVRTE 9
          PELEVV  E
Sbjct: 73 PELEVVYEE 81
>XP_006721904
          Length = 267

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PELEVVRTE 9
          PELEVV  E
Sbjct: 73 PELEVVYEE 81
>XP_006721903
          Length = 269

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PELEVVRTE 9
          PELEVV  E
Sbjct: 73 PELEVVYEE 81
>XP_006721902
          Length = 282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PELEVVRTE 9
          PELEVV  E
Sbjct: 73 PELEVVYEE 81
>XP_006721901
          Length = 293

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PELEVVRTE 9
          PELEVV  E
Sbjct: 73 PELEVVYEE 81
>XP_005257301
          Length = 308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PELEVVRTE 9
          PELEVV  E
Sbjct: 73 PELEVVYEE 81
>XP_006721900
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PELEVVRTE 9
          PELEVV  E
Sbjct: 73 PELEVVYEE 81
>XP_006718114
          Length = 1850

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>XP_005270318
          Length = 1860

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>XP_006718113
          Length = 1881

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>XP_006718112
          Length = 1889

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>XP_006718111
          Length = 1892

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>XP_006718110
          Length = 1893

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PELEVVRTE 9
          P LEV+R+E
Sbjct: 67 PFLEVIRSE 75
>XP_005273605
          Length = 1388

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    PELEVVRTE 9
            P+ E+++TE
Sbjct: 1096 PDAEIIKTE 1104
>XP_005273604
          Length = 1426

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    PELEVVRTE 9
            P+ E+++TE
Sbjct: 1145 PDAEIIKTE 1153
>NP_057427
          Length = 3114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    ELEVVRTE 9
            +LEVV+TE
Sbjct: 1924 DLEVVQTE 1931
>NP_003912
          Length = 233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   PELEVVRTE 9
           P LEV RTE
Sbjct: 175 PVLEVGRTE 183
>XP_005271368
          Length = 222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   PELEVVRTE 9
           P LEV RTE
Sbjct: 164 PVLEVGRTE 172
>NP_787028
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PELEVVRTE 9
           PE++ VRT+
Sbjct: 133 PEIQRVRTQ 141
>NP_473366
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LEVVRTE 9
          +EVVRTE
Sbjct: 64 VEVVRTE 70
>NP_001035536
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PELEVVRTE 9
           P  E+V+TE
Sbjct: 307 PPYEIVKTE 315
>NP_061114
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LEVVRTE 9
          +EVVRTE
Sbjct: 64 VEVVRTE 70
>XP_006722344
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PELEVVRTE 9
           PEL+ ++TE
Sbjct: 355 PELKRIKTE 363
>XP_005271567
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LEVVRTE 9
          +EVVRTE
Sbjct: 77 VEVVRTE 83
>XP_005271566
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LEVVRTE 9
          +EVVRTE
Sbjct: 77 VEVVRTE 83
>XP_005271565
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LEVVRTE 9
          +EVVRTE
Sbjct: 77 VEVVRTE 83
>XP_005271564
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LEVVRTE 9
          +EVVRTE
Sbjct: 77 VEVVRTE 83
>XP_005271563
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LEVVRTE 9
          +EVVRTE
Sbjct: 77 VEVVRTE 83
>XP_005248374
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PELEVVRTE 9
           P  E+V+TE
Sbjct: 307 PPYEIVKTE 315
>XP_005248373
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PELEVVRTE 9
           P  E+V+TE
Sbjct: 307 PPYEIVKTE 315
>XP_005248371
          Length = 711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PELEVVRTE 9
           P  E+V+TE
Sbjct: 307 PPYEIVKTE 315
>XP_005248370
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PELEVVRTE 9
           P  E+V+TE
Sbjct: 307 PPYEIVKTE 315
>NP_004505
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PELEVVRTE 9
           PEL+ ++TE
Sbjct: 627 PELKRIKTE 635
>NP_001177766
          Length = 1271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELEVVRTE 9
           ELEVVR +
Sbjct: 394 ELEVVRQQ 401
>NP_001128512
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELEVVRTE 9
           ELEVVR +
Sbjct: 381 ELEVVRQQ 388
>NP_004073
          Length = 1278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELEVVRTE 9
           ELEVVR +
Sbjct: 401 ELEVVRQQ 408
>NP_075408
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELEVVRTE 9
           ELEVVR +
Sbjct: 267 ELEVVRQQ 274
>NP_001128513
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELEVVRTE 9
           ELEVVR +
Sbjct: 267 ELEVVRQQ 274
>NP_001177765
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELEVVRTE 9
           ELEVVR +
Sbjct: 364 ELEVVRQQ 371
>NP_003631
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PELEVV 6
           PELE+V
Sbjct: 849 PELEIV 854
>NP_115642
          Length = 1984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PELEVVRT 8
            P+L +VRT
Sbjct: 1148 PQLHLVRT 1155
>NP_004178
          Length = 1560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PELEVVRT 8
            P+LE +RT
Sbjct: 1429 PDLERIRT 1436
>NP_001269551
          Length = 1559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PELEVVRT 8
            P+LE +RT
Sbjct: 1428 PDLERIRT 1435
>NP_001254542
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  PELEVVRT 8
          P LE VRT
Sbjct: 39 PRLESVRT 46
>NP_659482
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELEVVRTE 9
           E EVVRT+
Sbjct: 252 EAEVVRTK 259
>XP_005262092
          Length = 1557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PELEVVRT 8
            P+LE +RT
Sbjct: 1426 PDLERIRT 1433
>XP_005252342
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PELEVV 6
           PELE+V
Sbjct: 735 PELEIV 740
>NP_443073
          Length = 268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ELEVVRT 8
          EL++VRT
Sbjct: 58 ELQIVRT 64
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.130    0.332 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 539,134
Number of extensions: 1192
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package