Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     390
NP_078858                                                              20     509
NP_001278232                                                           20     509
NP_001278214                                                           20     509
NP_001784                                                              18    1935
NP_005236                                                              17    2528
NP_001399                                                              17    2528
XP_006714202                                                           17    2528
XP_005262892                                                           17    2528
XP_005262891                                                           17    2528
XP_006710468                                                           17    2528
XP_005270637                                                           17    2528
NP_001438                                                              17    3301
XP_006714824                                                           17    3301
NP_001783                                                              17    4312
NP_000205                                                              17    4312
NP_005520                                                              17    4312
XP_005258239                                                           17    4312
XP_005258238                                                           17    4312
XP_006710661                                                           17    4312
XP_005245920                                                           17    4312
XP_006710660                                                           17    4312
XP_006710659                                                           17    4312
XP_006710658                                                           17    4312
XP_006710657                                                           17    4312
NP_065168                                                              16    5631
NP_694545                                                              16    5631
NP_001074295                                                           16    7355
NP_001239268                                                           16    7355
NP_001239267                                                           16    7355
NP_001785                                                              16    7355
NP_060109                                                              16    7355
NP_003669                                                              16    7355
NP_001002878                                                           16    7355
NP_001002879                                                           16    7355
NP_001002877                                                           16    7355
XP_005261856                                                           16    7355
XP_006724410                                                           16    7355
XP_005261855                                                           16    7355
XP_005261854                                                           16    7355
XP_005272427                                                           16    7355
XP_005272426                                                           16    7355
NP_001001563                                                           16    7355
NP_001004480                                                           16    7355
NP_000375                                                              15    9605
NP_689777                                                              15    9605
NP_060360                                                              15    9605
NP_057664                                                              15    9605
NP_001098991                                                           15    9605
NP_055061                                                              15    9605
NP_061763                                                              15    9605
XP_006724446                                                           15    9605
XP_006717843                                                           15    9605
XP_005252734                                                           15    9605
XP_005252733                                                           15    9605
XP_005252732                                                           15    9605
XP_005252731                                                           15    9605
XP_005252730                                                           15    9605
XP_005252729                                                           15    9605
XP_005250858                                                           15    9605
XP_005250857                                                           15    9605
NP_660156                                                              15    9605
NP_061822                                                              15    9605
>NP_004351
          Length = 882

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAYTLVVQA 9
           P YTLVVQA
Sbjct: 339 PTYTLVVQA 347
>NP_078858
          Length = 4981

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    PAYTLVVQA 9
            PAY+LV+QA
Sbjct: 1279 PAYSLVIQA 1287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PAYTLVVQA 9
            P Y L VQA
Sbjct: 2223 PTYHLTVQA 2231
>NP_001278232
          Length = 4983

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    PAYTLVVQA 9
            PAY+LV+QA
Sbjct: 1279 PAYSLVIQA 1287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PAYTLVVQA 9
            P Y L VQA
Sbjct: 2223 PTYHLTVQA 2231
>NP_001278214
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    PAYTLVVQA 9
            PAY+LV+QA
Sbjct: 1279 PAYSLVIQA 1287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PAYTLVVQA 9
            P Y L VQA
Sbjct: 2223 PTYHLTVQA 2231
>NP_001784
          Length = 829

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAYTLVVQA 9
           P YTL +QA
Sbjct: 292 PEYTLTIQA 300
>NP_005236
          Length = 4588

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PAYTLVVQ 8
            P YTL++Q
Sbjct: 1731 PIYTLIIQ 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    YTLVVQA 9
            YTL VQA
Sbjct: 3406 YTLTVQA 3412
>NP_001399
          Length = 2923

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAYTLVVQA 9
           P Y LV+QA
Sbjct: 990 PEYVLVIQA 998
>XP_006714202
          Length = 4588

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PAYTLVVQ 8
            P YTL++Q
Sbjct: 1731 PIYTLIIQ 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    YTLVVQA 9
            YTL VQA
Sbjct: 3406 YTLTVQA 3412
>XP_005262892
          Length = 4600

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PAYTLVVQ 8
            P YTL++Q
Sbjct: 1731 PIYTLIIQ 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    YTLVVQA 9
            YTL VQA
Sbjct: 3406 YTLTVQA 3412
>XP_005262891
          Length = 4600

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PAYTLVVQ 8
            P YTL++Q
Sbjct: 1731 PIYTLIIQ 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    YTLVVQA 9
            YTL VQA
Sbjct: 3406 YTLTVQA 3412
>XP_006710468
          Length = 2916

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAYTLVVQA 9
           P Y LV+QA
Sbjct: 990 PEYVLVIQA 998
>XP_005270637
          Length = 2921

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAYTLVVQA 9
           P Y LV+QA
Sbjct: 990 PEYVLVIQA 998
>NP_001438
          Length = 4349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AYTLVVQA 9
           +YTL++QA
Sbjct: 114 SYTLIIQA 121
>XP_006714824
          Length = 4349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AYTLVVQA 9
           +YTL++QA
Sbjct: 114 SYTLIIQA 121
>NP_001783
          Length = 906

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTLVVQA 9
           YTL++QA
Sbjct: 345 YTLIIQA 351
>NP_000205
          Length = 1218

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PAYTLV 6
            PAYTLV
Sbjct: 1174 PAYTLV 1179
>NP_005520
          Length = 4391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PAYTLV 6
            PAYTLV
Sbjct: 1800 PAYTLV 1805
>XP_005258239
          Length = 875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTLVVQA 9
           YTL++QA
Sbjct: 314 YTLIIQA 320
>XP_005258238
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTLVVQA 9
           YTL++QA
Sbjct: 327 YTLIIQA 333
>XP_006710661
          Length = 4057

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PAYTLV 6
            PAYTLV
Sbjct: 1983 PAYTLV 1988
>XP_005245920
          Length = 4392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PAYTLV 6
            PAYTLV
Sbjct: 1801 PAYTLV 1806
>XP_006710660
          Length = 4397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PAYTLV 6
            PAYTLV
Sbjct: 1800 PAYTLV 1805
>XP_006710659
          Length = 4556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PAYTLV 6
            PAYTLV
Sbjct: 1959 PAYTLV 1964
>XP_006710658
          Length = 4563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PAYTLV 6
            PAYTLV
Sbjct: 1966 PAYTLV 1971
>XP_006710657
          Length = 4579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PAYTLV 6
            PAYTLV
Sbjct: 1982 PAYTLV 1987
>NP_065168
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PAYTLVVQA 9
           P Y+LVV+A
Sbjct: 331 PDYSLVVRA 339
>NP_694545
          Length = 514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   PAYTLVVQ 8
           P YTL+++
Sbjct: 118 PTYTLIIR 125
>NP_001074295
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PAYTLV 6
           PAYT+V
Sbjct: 157 PAYTMV 162
>NP_001239268
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTLVVQA 9
           YT++VQA
Sbjct: 281 YTVIVQA 287
>NP_001239267
          Length = 879

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTLVVQA 9
           YT++VQA
Sbjct: 318 YTVIVQA 324
>NP_001785
          Length = 916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTLVVQA 9
           YT++VQA
Sbjct: 355 YTVIVQA 361
>NP_060109
          Length = 2916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    AYTLVVQA 9
            +Y+L+VQA
Sbjct: 1857 SYSLIVQA 1864
>NP_003669
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PAYTLVVQA 9
           P Y L VQA
Sbjct: 267 PLYVLFVQA 275
>NP_001002878
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PAYTLVVQA 9
           P Y L VQA
Sbjct: 267 PLYVLFVQA 275
>NP_001002879
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PAYTLVVQA 9
           P Y L VQA
Sbjct: 267 PLYVLFVQA 275
>NP_001002877
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PAYTLVVQA 9
           P Y L VQA
Sbjct: 267 PLYVLFVQA 275
>XP_005261856
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PAYTLVVQA 9
           P Y L VQA
Sbjct: 267 PLYVLFVQA 275
>XP_006724410
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PAYTLVVQA 9
           P Y L VQA
Sbjct: 267 PLYVLFVQA 275
>XP_005261855
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PAYTLVVQA 9
           P Y L VQA
Sbjct: 267 PLYVLFVQA 275
>XP_005261854
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PAYTLVVQA 9
           P Y L VQA
Sbjct: 267 PLYVLFVQA 275
>XP_005272427
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PAYTLV 6
           PAYT+V
Sbjct: 157 PAYTMV 162
>XP_005272426
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   PAYTLV 6
           PAYT+V
Sbjct: 157 PAYTMV 162
>NP_001001563
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAYTLVVQ 8
           P YTLV++
Sbjct: 249 PPYTLVLE 256
>NP_001004480
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AYTLVVQA 9
           +YTLV++A
Sbjct: 235 SYTLVIRA 242
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    PAYTLVV 7
            P+YTL++
Sbjct: 3293 PSYTLIL 3299
>NP_689777
          Length = 3997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    PAYTLVVQ 8
            P Y++V+Q
Sbjct: 2780 PEYSIVIQ 2787
>NP_060360
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    PAYTLVVQ 8
            P Y++V+Q
Sbjct: 2805 PEYSIVIQ 2812
>NP_057664
          Length = 1184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAYTLVVQA 9
           PAY + VQA
Sbjct: 316 PAYEVDVQA 324
>NP_001098991
          Length = 844

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYTLVVQA 9
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>NP_055061
          Length = 3014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    YTLVVQA 9
            Y LVVQA
Sbjct: 1070 YVLVVQA 1076
>NP_061763
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTLVVQA 9
           YTL +QA
Sbjct: 315 YTLTIQA 321
>XP_006724446
          Length = 3019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    YTLVVQA 9
            Y LVVQA
Sbjct: 1070 YVLVVQA 1076
>XP_006717843
          Length = 844

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYTLVVQA 9
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252734
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYTLVVQA 9
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252733
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYTLVVQA 9
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252732
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYTLVVQA 9
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252731
          Length = 988

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYTLVVQA 9
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252730
          Length = 990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYTLVVQA 9
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252729
          Length = 990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYTLVVQA 9
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005250858
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    PAYTLVVQ 8
            P Y++V+Q
Sbjct: 2805 PEYSIVIQ 2812
>XP_005250857
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    PAYTLVVQ 8
            P Y++V+Q
Sbjct: 2805 PEYSIVIQ 2812
>NP_660156
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   PAYTLVVQ 8
           P Y L+VQ
Sbjct: 99  PIYKLIVQ 106
>NP_061822
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AYTLVV 7
          AYTLVV
Sbjct: 70 AYTLVV 75
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.129    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 346,956
Number of extensions: 428
Number of successful extensions: 70
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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