Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              18    1135
NP_653080                                                              18    1135
XP_005267292                                                           18    1135
XP_005267291                                                           18    1135
XP_005267290                                                           18    1135
NP_004247                                                              17    2528
NP_002799                                                              17    2528
NP_001265637                                                           17    2528
NP_001265638                                                           17    2528
NP_997275                                                              17    4312
NP_001231776                                                           17    4312
NP_004685                                                              16    5631
NP_001167637                                                           16    5631
XP_006722232                                                           16    5631
XP_005257846                                                           16    5631
NP_525022                                                              16    7355
NP_001275915                                                           16    7355
NP_001275914                                                           16    7355
NP_009099                                                              16    7355
NP_525021                                                              16    7355
XP_005256997                                                           16    7355
XP_005256995                                                           16    7355
XP_005256993                                                           16    7355
XP_005256992                                                           16    7355
XP_006721697                                                           16    7355
XP_006721696                                                           16    7355
XP_005256991                                                           16    7355
NP_443187                                                              16    7355
NP_001931                                                              15    9605
NP_001007027                                                           15    9605
NP_057336                                                              15    9605
NP_037361                                                              15    9605
NP_001155244                                                           15    9605
NP_000860                                                              15    9605
NP_998786                                                              15    9605
NP_060955                                                              15    9605
NP_863651                                                              15    9605
NP_001258679                                                           15    9605
NP_001275696                                                           15    9605
NP_036234                                                              15    9605
NP_001036147                                                           15    9605
NP_001036146                                                           15    9605
NP_001013712                                                           15    9605
NP_001258678                                                           15    9605
XP_005255638                                                           15    9605
XP_006721154                                                           15    9605
XP_005268927                                                           15    9605
XP_006712120                                                           15    9605
XP_005264512                                                           15    9605
XP_005264511                                                           15    9605
XP_006712119                                                           15    9605
XP_005264510                                                           15    9605
XP_006712118                                                           15    9605
XP_005264509                                                           15    9605
XP_005264508                                                           15    9605
XP_006712117                                                           15    9605
XP_005264507                                                           15    9605
XP_005264506                                                           15    9605
XP_006710717                                                           15    9605
XP_005263523                                                           15    9605
XP_005263522                                                           15    9605
XP_006710716                                                           15    9605
XP_005263521                                                           15    9605
NP_001098717                                                           15    9605
NP_079018                                                              15    9605
>NP_005091
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PAVV LSEY
Sbjct: 844 PAVVPLSEY 852
>NP_653080
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PAVV LSEY
Sbjct: 746 PAVVPLSEY 754
>XP_005267292
          Length = 1677

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PAVV LSEY
Sbjct: 739 PAVVPLSEY 747
>XP_005267291
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PAVV LSEY
Sbjct: 746 PAVVPLSEY 754
>XP_005267290
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PAVV LSEY
Sbjct: 844 PAVVPLSEY 852
>NP_004247
          Length = 551

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           P V+LL EY
Sbjct: 468 PLVILLGEY 476
>NP_002799
          Length = 908

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PA+ LLS+Y
Sbjct: 461 PALALLSDY 469
>NP_001265637
          Length = 778

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PA+ LLS+Y
Sbjct: 331 PALALLSDY 339
>NP_001265638
          Length = 749

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PA+ LLS+Y
Sbjct: 302 PALALLSDY 310
>NP_997275
          Length = 99

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  PAVVLLS 7
          PAVVLLS
Sbjct: 7  PAVVLLS 13
>NP_001231776
          Length = 85

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  PAVVLLS 7
          PAVVLLS
Sbjct: 7  PAVVLLS 13
>NP_004685
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           P V +LS+Y
Sbjct: 135 PTVTILSQY 143
>NP_001167637
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           P V +LS+Y
Sbjct: 135 PTVTILSQY 143
>XP_006722232
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           P V +LS+Y
Sbjct: 135 PTVTILSQY 143
>XP_005257846
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           P V +LS+Y
Sbjct: 135 PTVTILSQY 143
>NP_525022
          Length = 1624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1439 PSVVLLDE 1446
>NP_001275915
          Length = 1616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1431 PSVVLLDE 1438
>NP_001275914
          Length = 1621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1436 PSVVLLDE 1443
>NP_009099
          Length = 1581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1396 PSVVLLDE 1403
>NP_525021
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1358 PSVVLLDE 1365
>XP_005256997
          Length = 1560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1375 PSVVLLDE 1382
>XP_005256995
          Length = 1621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1436 PSVVLLDE 1443
>XP_005256993
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1358 PSVVLLDE 1365
>XP_005256992
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1358 PSVVLLDE 1365
>XP_006721697
          Length = 1625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1447 PSVVLLDE 1454
>XP_006721696
          Length = 1632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1447 PSVVLLDE 1454
>XP_005256991
          Length = 1632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    PAVVLLSE 8
            P+VVLL E
Sbjct: 1447 PSVVLLDE 1454
>NP_443187
          Length = 710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           P+ +LL EY
Sbjct: 153 PSEILLQEY 161
>NP_001931
          Length = 1190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           PA+  LSEY
Sbjct: 881 PALRTLSEY 889
>NP_001007027
          Length = 1190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           PA+  LSEY
Sbjct: 881 PALRTLSEY 889
>NP_057336
          Length = 4857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3215 PAAVLLKE 3222
>NP_037361
          Length = 1237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVVLLSEY 9
           AVV LS+Y
Sbjct: 844 AVVALSQY 851
>NP_001155244
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  PAVVLLSEY 9
          PA++ LS+Y
Sbjct: 17 PALLRLSDY 25
>NP_000860
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  PAVVLLSEY 9
          PA++ LS+Y
Sbjct: 38 PALLRLSDY 46
>NP_998786
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  PAVVLLSEY 9
          PA++ LS+Y
Sbjct: 38 PALLRLSDY 46
>NP_060955
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           P+++LL+ Y
Sbjct: 111 PSIILLTMY 119
>NP_863651
          Length = 1248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVVLLSEY 9
           AVV LS+Y
Sbjct: 855 AVVALSQY 862
>NP_001258679
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           P+++LL+ Y
Sbjct: 111 PSIILLTMY 119
>NP_001275696
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PA++LLS +
Sbjct: 619 PALLLLSRF 627
>NP_036234
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PAVVLLSEY 9
            PA+  LSEY
Sbjct: 1251 PALRTLSEY 1259
>NP_001036147
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           PA+  LSEY
Sbjct: 697 PALRTLSEY 705
>NP_001036146
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PAVVLLSEY 9
            PA+  LSEY
Sbjct: 1251 PALRTLSEY 1259
>NP_001013712
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PAVVLLSE 8
           P+V+L+SE
Sbjct: 485 PSVLLISE 492
>NP_001258678
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           P+++LL+ Y
Sbjct: 111 PSIILLTMY 119
>XP_005255638
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PA++LLS +
Sbjct: 556 PALLLLSRF 564
>XP_006721154
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PA++LLS +
Sbjct: 556 PALLLLSRF 564
>XP_005268927
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PAVVLLSE 8
           P+V+L+SE
Sbjct: 485 PSVLLISE 492
>XP_006712120
          Length = 4812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3170 PAAVLLKE 3177
>XP_005264512
          Length = 4840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3198 PAAVLLKE 3205
>XP_005264511
          Length = 4847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3242 PAAVLLKE 3249
>XP_006712119
          Length = 4851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3209 PAAVLLKE 3216
>XP_005264510
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3219 PAAVLLKE 3226
>XP_006712118
          Length = 4864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3242 PAAVLLKE 3249
>XP_005264509
          Length = 4870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3228 PAAVLLKE 3235
>XP_005264508
          Length = 4875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3233 PAAVLLKE 3240
>XP_006712117
          Length = 4878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3236 PAAVLLKE 3243
>XP_005264507
          Length = 4880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3238 PAAVLLKE 3245
>XP_005264506
          Length = 4884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    PAVVLLSE 8
            PA VLL E
Sbjct: 3242 PAAVLLKE 3249
>XP_006710717
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           PA+  LSEY
Sbjct: 856 PALRTLSEY 864
>XP_005263523
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAVVLLSEY 9
           PA+  LSEY
Sbjct: 983 PALRTLSEY 991
>XP_005263522
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PAVVLLSEY 9
            PA+  LSEY
Sbjct: 1209 PALRTLSEY 1217
>XP_006710716
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PAVVLLSEY 9
            PA+  LSEY
Sbjct: 1251 PALRTLSEY 1259
>XP_005263521
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PAVVLLSEY 9
            PA+  LSEY
Sbjct: 1251 PALRTLSEY 1259
>NP_001098717
          Length = 935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PA++LLS +
Sbjct: 524 PALLLLSRF 532
>NP_079018
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAVVLLSEY 9
           PA++LLS +
Sbjct: 524 PALLLLSRF 532
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.136    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 433,961
Number of extensions: 677
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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